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Author: Ajit Varki
Publisher: CSHL Press
Published: 1999
Total Pages: 694
ISBN-13: 9780879696818
DOWNLOAD EBOOKSugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Author: Hari G. Garg
Publisher: Elsevier
Published: 2011-10-10
Total Pages: 793
ISBN-13: 0080529054
DOWNLOAD EBOOKThe chemistry, biochemistry and pharmacology of heparin and heparan sulfate have been and continue to be a major scientific undertaking - heparin and its derivative remain important drugs in clinical practice. Chemistry and Biology of Heparin and Heparan Sulfate provides readers with an insight into the chemistry, biology and clinical applications of heparin and heparan sulfate and examines their function in various physiological and pathological conditions. Providing a wealth of useful information, no other tome covers the diversity of topics in the field. Students, doctors, chemists, biochemists, and research scientists will find this book an invaluable source for updating their current knowledge of developments in this area. - Comprehensively reviews all aspects of heparin and heparan sulfate research - Uniquely describes the chemistry, biology and clinical application of heparins and heparan sulfates in one work - Provides an invaluable source of knowledge of current developments for chemists, biochemists, medical doctors, researchers, students and practitioners
Author: 978-3-03842-836-7
Publisher: MDPI
Published: 2018-07-04
Total Pages: 247
ISBN-13: 3038428353
DOWNLOAD EBOOKThis book is a printed edition of the Special Issue "Glycosaminoglycans and Proteoglycans" that was published in Pharmaceuticals
Author: Renato V. Iozzo
Publisher: Springer Science & Business Media
Published: 2008-02-02
Total Pages: 547
ISBN-13: 1592592090
DOWNLOAD EBOOKProteoglycans are some of the most elaborate macromolecules of mammalian and lower organisms. The covalent attachment of at least five types of glycosami- glycan side chains to more than forty individual protein cores makes these molecules quite complex and endows them with a multitude of biological functions. Proteoglycan Protocols offers a comprehensive and up-to-date collection of prepa- tive and analytical methods for the in-depth analysis of proteoglycans. Featuring st- by-step detailed protocols, this book will enable both novice and experienced researchers to isolate intact proteoglycans from tissues and cultured cells, to establish the composition of their carbohydrate moieties, to generate strategies for prokaryotic and eukaryotic expression, to utilize methods for the suppression of specific proteoglycan gene expression and for the detection of mutant cells and degradation products, and to study specific interactions between proteoglycans and extracellular matrix proteins as well as growth factors and their receptors. The readers will find concise, yet comprehensive techniques carefully drafted by leading experts in the field. Each chapter commences with a general Introduction, followed by a detailed Materials section, and an easy-to-follow Methods section. An asset of each chapter is the extensive notation that includes troubleshooting tips and practical considerations that are often lacking in formal methodology papers. The reader will find this section most valuable because it is clearly provided by experienced scientists who have first-hand knowledge of the techniques they outline. In addition, most of the chapters are well illustrated with examples of typical data generated with each method.
Author: Israel Vlodavsky
Publisher: Springer Nature
Published: 2020-04-09
Total Pages: 871
ISBN-13: 3030345211
DOWNLOAD EBOOKWritten by internationally recognized leaders in Heparanase biology, the book’s eight chapters offer an opportunity for scientists, clinicians and advanced students in cell biology, tumor biology and oncology to obtain a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications. Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.
Author: J.T. Davies
Publisher: Academic Press
Published: 2012-12-02
Total Pages: 507
ISBN-13: 0323148344
DOWNLOAD EBOOKInterfacial Phenomena examines the fundamental properties of various liquid interfaces. This book discusses the physics of surfaces; electrostatic and electrokinetic phenomena; and adsorption at liquid interfaces. The properties of monolayers; reactions at liquid surfaces; diffusion through interfaces; and disperse systems and adhesion are also deliberated. Other topics include the vapor pressures over curved surfaces; electrical capacity of the double layer; applications of electrophoresis; and thermodynamics of adsorption and desorption. The experimental methods of spreading films at the oil-water interface; penetration into monolayers; experiments on dynamic systems; and spontaneous emulsification are likewise covered in this text. This book is beneficial to chemical engineers and students concerned with interfacial phenomena.
Author: Mauro S.G. Pavão
Publisher: Springer Science & Business Media
Published: 2011-04-19
Total Pages: 197
ISBN-13: 3642168337
DOWNLOAD EBOOKInitially believed to be inactive molecules, glycans are now considered essential for life, both under normal and pathological conditions. This volume of the series “Biology of Extracellular Matrix” reviews the most recent findings on the role of glycans in the development of diseases and the possible therapeutic use of this class of molecules. It shows how the interaction of glycans with growth factors, growth factor binding proteins, extracellular proteases, protease inhibitors, chemokines, morphogens, and adhesive proteins regulates inflammation, infection, cancer, atherosclerosis, thrombosis and embryonic stem cell biology. Furthermore, an extensive survey about the structure and pharmacological effects of unique marine glycosaminoglycans is discussed as well as the possibility of using these glycans as therapeutic agents.
Author: Robert Mecham
Publisher: Springer Science & Business Media
Published: 2011-02-16
Total Pages: 429
ISBN-13: 3642165559
DOWNLOAD EBOOKKnowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.
Author: Struther Arnott
Publisher: Springer Science & Business Media
Published: 1984-10-19
Total Pages: 216
ISBN-13:
DOWNLOAD EBOOKBiopolymers, such as proteins and nucleic acids have been subjected to a rational succession of structural studies in which the determination of chemical compositions, link ages, and sequences is followed by investigations of molecu lar architecture and interactions. By the end of the 1960s the covalent structures of glycosaminoglycans and proteo glycans had been defined both within the carbohydrate chains and in respect to their linkages to protein. The scene was therefore set for successful probing of three dimensional shapes and intermolecular associations. For tunately, during the 1970s appropriate physical methods were themselves greatly increasing in power. Consequently much progress has been made using X-ray diffraction anal ysis of hydrated films, nuclear magnetic resonance spectro scopy, and chromatographie methods for investigation of molecular interactions in solution. We now have a great deal of information about molecular shapes, their sensitiv ity to environment (especially associated cations), and their modes of interaction that could be relevant to super molecular assemblies in biological milieux. For these rea sons we judged that it would be timely to distil the main conclusions from this phase of research to prepare for the next, which will involve detailed study of the interplay be tween biological function and molecular structure. The idea for this volume emerged from a workshop meeting at Colworth sponsored by the Biochemical Society.
Author: Robert C. Bast, Jr.
Publisher: John Wiley & Sons
Published: 2017-03-10
Total Pages: 2004
ISBN-13: 111900084X
DOWNLOAD EBOOKHolland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
