Advances in Protein Kinases
Advances in Protein Kinases

Author: Gabriela Da Silva Xavier

Publisher: BoD – Books on Demand

Published: 2012-06-05

Total Pages: 388

ISBN-13: 9535106333

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Proteins are the work horses of the cell. As regulators of protein function, protein kinases are involved in the control of cellular functions via intricate signalling pathways, allowing for fine tuning of physiological functions. This book is a collaborative effort, with contribution from experts in their respective fields, reflecting the spirit of collaboration - across disciplines and borders - that exists in modern science. Here, we review the existing literature and, on occasions, provide novel data on the function of protein kinases in various systems. We also discuss the implications of these findings in the context of disease, treatment, and drug development.

Mitogen Activated Protein Kinases
Mitogen Activated Protein Kinases

Author: Ritva Tikkanen

Publisher: MDPI

Published: 2020-06-18

Total Pages: 276

ISBN-13: 3039280708

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Mitogen-activated protein kinases (MAPK) are a large family of enzymes that function as signal transducers to regulate a diverse range of physiological responses. However, signaling via extracellular signal-regulated kinase (ERK), c-Jun amino terminal kinase (JNK), and p38 MAPK also underpin many disease processes. This Special Issue provides new insights into how MAPK signaling contributes to specific pathological processes across a range of conditions, including disorders of lung development, type 2 diabetes, proliferative skin diseases, cardiovascular diseases, and neurological diseases.

Protein Kinases
Protein Kinases

Author: Gabriela Da Silva Xavier

Publisher: BoD – Books on Demand

Published: 2012-06-05

Total Pages: 498

ISBN-13: 9535106406

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Proteins are the work horses of the cell. As regulators of protein function, protein kinases are involved in the control of cellular functions via intricate signalling pathways, allowing for fine tuning of physiological functions. This book is a collaborative effort, with contribution from experts in their respective fields, reflecting the spirit of collaboration - across disciplines and borders - that exists in modern science. Here, we review the existing literature and, on occasions, provide novel data on the function of protein kinases in various systems. We also discuss the implications of these findings in the context of disease, treatment, and drug development.

Protein Kinase Functions
Protein Kinase Functions

Author: James Woodgett

Publisher: OUP Oxford

Published: 2000-08-24

Total Pages: 407

ISBN-13: 0191565962

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Since the publication of Protein Kinases in 1994 many novel protein kinases have been discovered, but perhaps more importantly there have been dramatic advances in our understanding of the cellular functions of this remarkably diverse class of proteins. Protein Kinase Functions is not just an update of the previous edition but provides a new focus on the context and function of protein kinases, thus reflecting the recent advances in kinase biology. Chapters on genetic approaches to protein kinase functions, the MAP kinase pathway, and cyclin-dependent kinases have been completely updated and new topics covered in depth are: phosphatidylinositol 3-kinase signalling, JAK-STAT signalling, suppression of tyrosine kinases by the SOCS family proteins, the TGFß superfamily, and the involvement of protein kinases in response to DNA damage. Throughout, emphasis is placed not on individual kinases, but on the functional aspects of the whole system and the relationship between processes and molecules. It is the aim of Protein Kinase Functions to enable the reader to assimilate, compare, and integrate the molecular machinery used by cells to co-ordinate and respond to their environments.

Protein Kinases—Advances in Research and Application: 2012 Edition
Protein Kinases—Advances in Research and Application: 2012 Edition

Author:

Publisher: ScholarlyEditions

Published: 2012-12-26

Total Pages: 111

ISBN-13: 1481602934

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Protein Kinases—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Protein Kinases. The editors have built Protein Kinases—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Protein Kinases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Protein Kinases—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Protein Kinases: Advances in Research and Application: 2011 Edition
Protein Kinases: Advances in Research and Application: 2011 Edition

Author:

Publisher: ScholarlyEditions

Published: 2012-01-09

Total Pages: 117

ISBN-13: 1464929505

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Protein Kinases: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Protein Kinases. The editors have built Protein Kinases: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Protein Kinases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Protein Kinases: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Protein Kinases in Development and Disease
Protein Kinases in Development and Disease

Author:

Publisher: Academic Press

Published: 2017-02-22

Total Pages: 500

ISBN-13: 0128016248

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Protein Kinases in Development and Disease discusses and reviews important, but often neglected, kinases. A good representation of current model organisms from plants and C. elegans to mice are used as the basis to illustrate how we can use our understanding of normal development to learn about disease. Reviews kinases, the fundamental regulators of most biological processes that have key roles in the development of all organisms Includes a broad scope of topics that are addressed Allows researchers and newcomers to this research area to gain a thorough picture of the current knowledge

Protein Kinases as Drug Targets
Protein Kinases as Drug Targets

Author: Bert Klebl

Publisher: John Wiley & Sons

Published: 2011-03-16

Total Pages: 570

ISBN-13: 3527633499

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This timely guide to kinase inhibitor drug development is the first to cover the entire drug pipeline, from target identification to compound development and clinical application. Edited by the pioneers in the field, on the drug development side this ready reference discusses classical medicinal chemistry approaches as well as current chemical genomics strategies. On the clinical side, both current and future therapeutic application areas for kinase inhibitor drugs are addressed, with a strong focus on oncology drugs. Backed by recent clinical experience with first-generation drugs in the battle against various forms of cancer, this is crucial reading for medicinal, pharmaceutical and biochemists, molecular biologists, and oncologists, as well as those working in the pharmaceutical industry.

Stress-Activated Protein Kinases
Stress-Activated Protein Kinases

Author: Francesc Posas

Publisher: Springer Science & Business Media

Published: 2008-01-24

Total Pages: 322

ISBN-13: 3540755691

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In this book leading researchers in the field discuss the state-of-the-art of many aspects of SAPK signaling in various systems from yeast to mammals. These include various chapters on regulatory mechanisms as well as the contribution of the SAPK signaling pathways to processes such as gene expression, metabolism, cell cycle regulation, immune responses and tumorigenesis. Written by international experts, the book will appeal to cell biologists and biochemists.