Synthetic Explorations in the Pursuit of a Rapid, Photoactivatable, Nitroxyl Donor
Synthetic Explorations in the Pursuit of a Rapid, Photoactivatable, Nitroxyl Donor

Author: Mark Wesley Campbell

Publisher:

Published: 2017

Total Pages: 176

ISBN-13:

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Nitroxyl (HNO) is a biologically relevant small molecule with considerable clinical promise for the treatment of heart failure. However, studies of the chemistry and biology of nitroxyl are hampered by its instability in aqueous solution. To aid in biological and chemical studies, nitroxyl donors (molecules that degrade to release HNO) have been synthesized which utilize a 3-hydroxy-2-naphthyl methyl (HNM) OH protecting group. Our group0́9s focus is on the synthesis of nitroxyl donors that rapidly release HNO under physiological conditions through photoactivation. First generation HNO donors released HNO upon photoactivation, but competition was also observed from a redox side reaction. In this study, we are probing the impact of a methyl substituent at the benzylic position on these competing processes. The synthesis and photochemical anaylsis of such a donor are herein described.

Synthetic Applications
Synthetic Applications

Author: Rajender S. Varma

Publisher: Walter de Gruyter GmbH & Co KG

Published: 2022-05-09

Total Pages: 578

ISBN-13: 3110730472

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Magnetic nanocatalysts are becoming an important tool for greener catalytic processes in chemical transformations in view of the ease of their removal from a reaction medium. This book explores assorted magnetic nanocatalysts, their deployment in synthesis, chemical transformation and their recovery and reuse. Various thematic topics embodied include magnetic nanocatalysts for S-S bond formation, N-heterocycle formation, C-heteroatom bond formation, silica-supported catalysts, multicomponent reactions, including their recyclability; another available volume emphasizes the utility of magnetic nanocatalysts in industrial appliances.

Cross-coupling Reactions
Cross-coupling Reactions

Author: Joffrey Vrijdag

Publisher:

Published: 2020

Total Pages: 268

ISBN-13: 9781536176957

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"Cross-Coupling Reactions: An Overview opens with an overview of the fundamentals and applications of the young and fast developing area of transition metal catalyzed/mediated oxidative (dehydrogenative) C-H/C-H coupling reactions between two (hetero)arenes. Continuing, the authors highlight the recent advances regarding the ligand supported transition metal-catalyzed domino (cascade) or one-pot syntheses of various heterocycles involving cross-coupling reactions. The recent advances in Cu catalyzed tandem reactions for heterocycle synthesis are also addressed. Cu metal chemistry has garnered attention as a potential alternative to precious transition metals, being cheaper, more sustainable and more easily available. A comprehensive account of research on green chemical routes is provided, involving various palladium metal-based catalysts utilized in facilitating cross-coupling reaction in aqueous media. Reported decarboxylative cross-coupling reactions are discussed along with suitable examples, focusing on their mechanism of action"--

Photoorganocatalysis In Organic Synthesis
Photoorganocatalysis In Organic Synthesis

Author: Maurizio Fagnoni

Publisher: World Scientific

Published: 2019-02-19

Total Pages: 600

ISBN-13: 1786346060

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The use of organocatalysts able to photocatalyze an organic reaction is a rapidly growing field. These photocatalyzed transformations are more environmentally sustainable with respect to the use of expensive/toxic metal-based (photo)catalysts.Based on the authors' extensive experience in photogenerated intermediates, this book presents an overview on photocatalyzed organic processes having a synthetic significance, where an organic molecule functions as the photocatalyst.After a brief introduction defining the nature and the characteristics of a photoorganocatalyst (POC), the chapters are organized according to the class of POC used, as detailed below.Each chapter begins with a summary of the photophysical characteristics of the POCs and is followed by selected examples of synthetic applications. The last two chapters are devoted to the adoption of photoorganocatalysis in polymerization and to flow photoorganocatalysis. These in-depth explanations and practical applications make this title an essential reading for any chemistry student interested in organic (sustainable) synthesis.

Visible Light Photocatalysis in Organic Chemistry
Visible Light Photocatalysis in Organic Chemistry

Author: Corey R.J. Stephenson

Publisher: John Wiley & Sons

Published: 2018-05-29

Total Pages: 454

ISBN-13: 3527335609

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Filling the need for a ready reference that reflects the vast developments in this field, this book presents everything from fundamentals, applications, various reaction types, and technical applications. Edited by rising stars in the scientific community, the text focuses solely on visible light photocatalysis in the context of organic chemistry. This primarily entails photoinduced electron transfer and energy transfer chemistry sensitized by polypyridyl complexes, yet also includes the use of organic dyes and heterogeneous catalysts. A valuable resource to the synthetic organic community, polymer and medicinal chemists, as well as industry professionals.

New-Generation Bioinorganic Complexes
New-Generation Bioinorganic Complexes

Author: Renata Jastrzab

Publisher: Walter de Gruyter GmbH & Co KG

Published: 2016-03-21

Total Pages: 325

ISBN-13: 3110386445

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Bio-Inorganic compounds are successfully applied as therapeutic agents since decades. Thus, scientist designed new metal complexes bearing biomolecules as ligands, investigating their potential as bioactive and therapeutic agents. This book presents a comprehensive overview on materials design, substance classes and their characterization. This book is compiled for scientists interested in medical application of bioinspired materials.

Photochemistry of Organic Compounds
Photochemistry of Organic Compounds

Author: Petr Klán

Publisher: John Wiley & Sons

Published: 2009-03-23

Total Pages: 583

ISBN-13: 1405190884

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Photochemistry of Organic Compounds: From Concepts to Practice provides a hands-on guide demonstrating the underlying principles of photochemistry and, by reference to a range of organic reaction types, its effective use in the synthesis of new organic compounds and in various applications. The book presents a complete and methodical approach to the topic, Working from basic principles, discussing key techniques and studies of reactive intermediates, and illustrating synthetic photochemical procedures. Incorporating special topics and case studies covering various applications of photochemistry in chemistry, environmental sciences, biochemistry, physics, medicine, and industry. Providing extensive references to the original literature and to review articles. Concluding with a chapter on retrosynthetic photochemistry, listing key reactions to aid the reader in designing their own synthetic pathways. This book will be a valuable source of information and inspiration for postgraduates as well as professionals from a wide range of chemical and natural sciences.

Caged Compounds
Caged Compounds

Author: Gerard Marriott

Publisher: Academic Press

Published: 1998-06-22

Total Pages: 584

ISBN-13:

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The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 285 volumes have been published (all of them still in print) and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences.

Metal-catalyzed Cross-coupling Reactions
Metal-catalyzed Cross-coupling Reactions

Author: François Diederich

Publisher: John Wiley & Sons

Published: 2008-07-11

Total Pages: 540

ISBN-13: 3527612203

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Carbon-carbon bond forming reactions are arguably the most important processes in chemistry, as they represent key steps in the building of complex molecules from simple precursors. Among these reactions, metal-catalyzed cross-coupling reactions are extensively employed in a wide range of areas of preparative organic chemistry, ranging from the synthesis of complex natural products, to supramolecular chemistry, and materials science. In this work, a dozen internationally renowned experts and leaders in the field bring the reader up to date by documenting and critically analyzing current developments and uses of metal-catalyzed cross-coupling reactions. A particularly attractive and useful feature, that enhances the practical value of this monograph, is the inclusion of key synthetic protocols, in experimental format, chosen for broad utility and application. This practice-oriented book can offer the practitioner short cuts to ensure they remain up-to-date with the latest developments.