The Children of Atomic Bomb Survivors
The Children of Atomic Bomb Survivors

Author: National Research Council

Publisher: National Academies Press

Published: 1991-02-01

Total Pages: 524

ISBN-13: 0309045371

DOWNLOAD EBOOK

Do persons exposed to radiation suffer genetic effects that threaten their yet-to-be-born children? Researchers are concluding that the genetic risks of radiation are less than previously thought. This finding is explored in this volume about the children of atomic bomb survivors in Hiroshima and Nagasakiâ€"the population that can provide the greatest insight into this critical issue. Assembled here for the first time are papers representing more than 40 years of research. These documents reveal key results related to radiation's effects on pregnancy termination, sex ratio, congenital defects, and early mortality of children. Edited by two of the principal architects of the studies, J. V. Neel and W. J. Schull, the volume also offers an important comparison with studies of the genetic effects of radiation on mice. The wealth of technical details will be immediately useful to geneticists and other specialists. Policymakers will be interested in the overall conclusions and discussion of future studies.

Cancer in Atomic Bomb Survivors
Cancer in Atomic Bomb Survivors

Author: I. Shigematsu

Publisher: Springer

Published: 1986-09-30

Total Pages: 212

ISBN-13:

DOWNLOAD EBOOK

Follow-up studies of persons exposed to medical radiation have long shown that radiation induces cancer in man. This, coupled with increasing exposure from other sources including occupational and environmental radiations, has resulted in greater recognition of the importance of research on radiation-induced carcinogenesis and risk assessment with a view to radiation protection. One of the well-known late effects of radiation is the increased incidence of leukemia that occurred among atomic bomb survivors beginning two or three years after expo sure. A remarkable increase of solid tumors including cancers of the thyroid, breast and lung was also observed 10 to 20 years after exposure. Thus, many pathological, clinical and epidemiological studies have been made on radiation carcinogenesis in atomic bomb survivors by investigators at the Atomic Bomb Casualty Commission (ABCC), now known as the Radiation Effects Research Foundation (RERF), as well as by the staff of universities in Hiroshima and Nagasaki. Some of the mechanisms involved in radia tion carcinogenesis in man and associated modifying factors, such as age at time of ex posure and sex, have been elucidated by these studies. The results obtained are being used by such agencies as the International Commission on Radiation Protection (ICRP) for risk estimations of radiation exposure. This monograph presents the results realized thus far in these epidemiological and The incidence of radiation-induced cancer among atomic bomb pathological studies.

Health Risks from Exposure to Low Levels of Ionizing Radiation
Health Risks from Exposure to Low Levels of Ionizing Radiation

Author: Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation

Publisher: National Academies Press

Published: 2006-03-23

Total Pages: 422

ISBN-13: 0309133343

DOWNLOAD EBOOK

This book is the seventh in a series of titles from the National Research Council that addresses the effects of exposure to low dose LET (Linear Energy Transfer) ionizing radiation and human health. Updating information previously presented in the 1990 publication, Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR V, this book draws upon new data in both epidemiologic and experimental research. Ionizing radiation arises from both natural and man-made sources and at very high doses can produce damaging effects in human tissue that can be evident within days after exposure. However, it is the low-dose exposures that are the focus of this book. So-called “late” effects, such as cancer, are produced many years after the initial exposure. This book is among the first of its kind to include detailed risk estimates for cancer incidence in addition to cancer mortality. BEIR VII offers a full review of the available biological, biophysical, and epidemiological literature since the last BEIR report on the subject and develops the most up-to-date and comprehensive risk estimates for cancer and other health effects from exposure to low-level ionizing radiation.

Analysis of Cancer Risks in Populations Near Nuclear Facilities
Analysis of Cancer Risks in Populations Near Nuclear Facilities

Author: National Research Council

Publisher: National Academies Press

Published: 2012-06-29

Total Pages: 424

ISBN-13: 0309255716

DOWNLOAD EBOOK

In the late 1980s, the National Cancer Institute initiated an investigation of cancer risks in populations near 52 commercial nuclear power plants and 10 Department of Energy nuclear facilities (including research and nuclear weapons production facilities and one reprocessing plant) in the United States. The results of the NCI investigation were used a primary resource for communicating with the public about the cancer risks near the nuclear facilities. However, this study is now over 20 years old. The U.S. Nuclear Regulatory Commission requested that the National Academy of Sciences provide an updated assessment of cancer risks in populations near USNRC-licensed nuclear facilities that utilize or process uranium for the production of electricity. Analysis of Cancer Risks in Populations near Nuclear Facilities: Phase 1 focuses on identifying scientifically sound approaches for carrying out an assessment of cancer risks associated with living near a nuclear facility, judgments about the strengths and weaknesses of various statistical power, ability to assess potential confounding factors, possible biases, and required effort. The results from this Phase 1 study will be used to inform the design of cancer risk assessment, which will be carried out in Phase 2. This report is beneficial for the general public, communities near nuclear facilities, stakeholders, healthcare providers, policy makers, state and local officials, community leaders, and the media.

Health Risks of Radon and Other Internally Deposited Alpha-Emitters
Health Risks of Radon and Other Internally Deposited Alpha-Emitters

Author: National Research Council

Publisher: National Academies Press

Published: 1988-02-01

Total Pages: 623

ISBN-13: 0309037891

DOWNLOAD EBOOK

This book describes hazards from radon progeny and other alpha-emitters that humans may inhale or ingest from their environment. In their analysis, the authors summarize in one document clinical and epidemiological evidence, the results of animal studies, research on alpha-particle damage at the cellular level, metabolic pathways for internal alpha-emitters, dosimetry and microdosimetry of radionuclides deposited in specific tissues, and the chemical toxicity of some low-specific-activity alpha-emitters. Techniques for estimating the risks to humans posed by radon and other internally deposited alpha-emitters are offered, along with a discussion of formulas, models, methods, and the level of uncertainty inherent in the risk estimates.

Health Effects of Exposure to Low Levels of Ionizing Radiation
Health Effects of Exposure to Low Levels of Ionizing Radiation

Author: National Research Council

Publisher: National Academies

Published: 1990-02-01

Total Pages: 436

ISBN-13: 0309039959

DOWNLOAD EBOOK

This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.

Targeted Radionuclide Therapy
Targeted Radionuclide Therapy

Author: Tod W. Speer

Publisher: Lippincott Williams & Wilkins

Published: 2012-03-28

Total Pages: 564

ISBN-13: 1451153260

DOWNLOAD EBOOK

Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion. A companion website includes the full text and an image bank.

The Future of Low Dose Radiation Research in the United States
The Future of Low Dose Radiation Research in the United States

Author: National Academies of Sciences, Engineering, and Medicine

Publisher: National Academies Press

Published: 2020-01-13

Total Pages: 143

ISBN-13: 030949771X

DOWNLOAD EBOOK

Exposures at low doses of radiation, generally taken to mean doses below 100 millisieverts, are of primary interest for setting standards for protecting individuals against the adverse effects of ionizing radiation. However, there are considerable uncertainties associated with current best estimates of risks and gaps in knowledge on critical scientific issues that relate to low dose radiation. The Nuclear and Radiation Studies Board of the National Academies hosted the symposium on The Future of Low Dose Radiation Research in the United States on May 8 and 9, 2019. The goal of the symposium was to provide an open forum for a national discussion on the need for a long-term strategy to guide a low dose radiation research program in the United States. The symposium featured presentations on low dose radiation programs around the world, panel discussions with representatives from governmental and nongovernmental organizations about the need for a low dose radiation research program, reviews of low dose radiation research in epidemiology and radiation biology including new directions, and lessons to be learned from setting up large research programs in non-radiation research fields. This publication summarizes the presentation and discussion of the symposium.