Mueller-Matrix Tomography of Biological Tissues and Fluids
Mueller-Matrix Tomography of Biological Tissues and Fluids

Author: Zhengbing Hu

Publisher: Springer Nature

Published: 2024-01-03

Total Pages: 126

ISBN-13: 9819982286

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This book presents experimental investigations and digital image processing, highlighting the interaction of polarized radiation with phase-inhomogeneous and optically anisotropic biological layers. The promising and efficient use of vector-parametric description of the formation of polarization-inhomogeneous object fields is noted. Applications of a set of Mueller-matrix polarimetry methods are highlighted. The book includes- structural and logical scheme of multi-parameter (singular, interference and layer-by-layer Stokes-polarimetric), polarization-correlation study of the structure of distributions of the number of singularities, maps of local contrast of interference distributions and layer-by-layer maps of microscopic polarization azimuth and ellipticity; determination of relationships between changes in the magnitude of statistical parameters characterizing polarization-correlation distributions and pathology of prostate tumors.

Polarization Correlometry of Scattering Biological Tissues and Fluids
Polarization Correlometry of Scattering Biological Tissues and Fluids

Author: V. T. Bachinskyi

Publisher: Springer Nature

Published: 2020-04-08

Total Pages: 82

ISBN-13: 9811526281

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This book presents a new diagnostic approach that utilizes complex statistical, correlation, fractal, and singular analysis of spatial distribution of the Stokes vector of scattered polarized light in different diffraction zones. The technique is able to identify changes in the distribution of optical axes and the birefringent indices of multi-layered fibrillar networks of biological tissues. The book also presents various scenarios for the formation of polarization singularities in laser speckle images of phase-inhomogeneous, multi-layered biological tissues in terms of the characteristic values of Mueller-matrix images. Moreover, in the context of potential diagnostic applications, it discusses the states of polarization singularities and their changes associated with the pathological abnormalities of the extracellular matrix of human tissues, its spatial peculiarities and structural orientation.

Information Technology in Medical Diagnostics
Information Technology in Medical Diagnostics

Author: Waldemar Wójcik

Publisher: CRC Press

Published: 2017-07-20

Total Pages: 208

ISBN-13: 1351578944

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For many centuries, people have tried to learn about the state of their health. Initially, in the pre-technological period, they had to rely only on their senses. Then there were simple tools to help the human senses. The discovery of X-rays, which allowed people to look “inside” the body, turned out to be a major breakthrough. Contemporary medical diagnostics is increasingly being assisted by information technology that allows, for example, thorough image tissue analysis or pathology differentiation. They also allow very early preventive diagnostics. Influenced by information technology, “classic” diagnostic techniques change and new ones arise. Information Technology in Medical Diagnostics presents selected and extended conference papers from Polish, Ukrainian and Kazakh scientists. They address problems of the application of new methods of image processing for analysis of medical images, new methods of classification of medical data as well as new medical imaging methods. Some of the presented technologies are inspired by the functioning of living organisms. Information Technology in Medical Diagnostics is of interest not only to academics and engineers, but also to professionals involved in biomedical engineering, and seeking for solutions for issues that cannot be solved with the help of “traditional” technologies.

Multi-parameter Mueller Matrix Microscopy for the Expert Assessment of Acute Myocardium Ischemia
Multi-parameter Mueller Matrix Microscopy for the Expert Assessment of Acute Myocardium Ischemia

Author: Victor Bachinsky

Publisher: Springer Nature

Published: 2021-04-13

Total Pages: 90

ISBN-13: 9811614504

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This book provides an essential overview of the basic principles of imaging modalities, accompanied by examples of their applications in modern clinical and associated pre-clinical studies. The monograph is based on the original results of investigation of the efficiency use of laser light and Mueller-matrix polarimetry approach for assessment of myocardial tissues towards confirmation the cause of death. A morphological analysis of necrotic changes in the myocardial tissue of patients that died due to heart attack, coronary heart disease and acute coronary insufficiency was carried out and the data and histological sections of the myocardium inspected utilizing Mueller-matrix mapping of tissue samples with polarized light. A unified optical model of polycrystalline structure of the myocardium is proposed, and the principles and regulations of Mueller-matrix description of its polarization manifestations are explored and developed. The book also provides a statistical and scale-selective wavelet analysis of polarization and Mueller-matrix maps. Finally, the key forensic medical criteria for the differential diagnosis of the cause of death due to necrotic and pathological changes in the morphological structure of the myocardium have been established

Optical Polarimetric Modalities for Biomedical Research
Optical Polarimetric Modalities for Biomedical Research

Author: Nirmal Mazumder

Publisher: Springer Nature

Published: 2023-07-25

Total Pages: 455

ISBN-13: 3031318528

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This book focuses on polarization microscopy, a powerful optical tool used to study anisotropic properties in biomolecules, and its enormous potential to improve diagnostic tools for various biomedical research. The interaction of polarized light with normal and abnormal regions of tissue reveals structural information associated with its pathological condition. Diagnosis using conventional microscopy can be time-consuming, as pathologists require an hour to freeze and stain tissue slices from suspected patients. In comparison, polarization microscopy more quickly distinguishes abnormal tissue and provides better microstructural information of samples, even in the absence of staining. This book provides a basic understanding of the properties of polarized light, a description of the polarization microscope, and a mathematical formalism of Mueller matrix polarimetry. The authors discuss various advanced linear and nonlinear optical techniques such as optical coherence tomography (OCT), reflectance and transmission spectroscopy, fluorescence, multiphoton excitation, second harmonic generation, Raman microscopy, and more. They explore the exciting potential of integrating polarimetry with these techniques for possible applications in different areas of biomedical research, as well as the associated challenges. Including the most recent developments on the topic, this book serves as a modern guide to polarization microscopy and advancements in its use in biomedical research.

Optical Anisotropy of Biological Polycrystalline Networks
Optical Anisotropy of Biological Polycrystalline Networks

Author: Lilia Trifonyuk

Publisher: Springer Nature

Published: 2023-05-29

Total Pages: 103

ISBN-13: 9819910870

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This book highlights the analysis of new azimuth-independent methods of Stokes polarimetry and Mueller-matrix reconstruction of distributions of optical anisotropy parameters using spatial-frequency filtering of manifestations of phase (linear and circular birefringence) and amplitude (linear and circular dichroism) anisotropy for diagnosing changes in the orientational-phase structure of fibrillar networks of histological sections of biological tissues and polycrystalline films of biological fluids.

Polarized Light in Biomedical Imaging and Sensing
Polarized Light in Biomedical Imaging and Sensing

Author: Jessica C. Ramella-Roman

Publisher: Springer Nature

Published: 2022-11-14

Total Pages: 362

ISBN-13: 3031047419

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This book focuses on biomedical applications of polarized light, covering instrumentation and modeling specific to the field. This will be the first book, written by leading researchers in the field, to tackle this important topic. Readers will learn the fundamentals of polarized light transport and how to develop instrumentation for clinical and preclinical studies. They will also become familiar with the latest advancement in data analysis and image processing for a variety of medical applications. The book is dedicated specifically to the biomedical community, including scientists, engineers, and physicians working on the development of instrumentation for clinical and preclinical use. Emphasizes biomedical imaging and sensing; Describes new computational approaches with examples; Provides detailed descriptions of novel instrumentation.

Laser Polarimetry of Biological Tissues
Laser Polarimetry of Biological Tissues

Author: Zhengbin Hu

Publisher: Springer Nature

Published: 2023-06-16

Total Pages: 107

ISBN-13: 9819917344

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This book highlights the results of numerical computer-aided smart methods as part of a comprehensive statistical, correlated, and fractal analysis of laser polarimetry. It includes a comprehensive approach to differentiation of lifelong or postmortem origin of injuries and determination of their antiquity based on the analysis of statistical and spatiotemporal frequency evolution of photometric, polarization, and phase parameters of laser images of histological sections of the skin of biomannequins. It discusses the relationship between the coordinate distributions of the intensity of laser images from skin tissues of biomannequins and the nature of its damage. It presents the analysis of relationships between changes in the mean and variance of coordinate distributions of azimuths and ellipticity of polarization images of histological skin sections and the time intervals after injury. Complex differentiation of lifelong and postmortem skin injuries of biomannequins and establishment of their time intervals throughout the entire monitoring interval of changes in the mean and variance of coordinate distributions of phase shifts between orthogonal components of the amplitude of laser images of a series of corresponding histological sections are also presented in this book.

Phase Mapping of Human Biological Tissues
Phase Mapping of Human Biological Tissues

Author: Zhengbin Hu

Publisher: Springer Nature

Published: 2023-06-20

Total Pages: 81

ISBN-13: 9819932696

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This book presents numerical computer-aided smart-methods as part of a comprehensive statistical, correlation and fractal analysis of laser polarimetry data. It highlights relationships between polarization (azimuth distributions, polarization ellipticities, Stokes vector parameters, Mueller matrix elements) parameters of laser images of biological tissues of a human corpse in different spectral ranges and temporal dynamics of their postmortem morphological changes. The book discusses the effectiveness of correlation analysis of two-dimensional distributions of polarization inhomogeneous images of histological sections of the main types of biological tissues in determining the time of death. It also discusses the development of basic principles of phase measurements (phasometry) of microscopic images of biological tissues to determine the age of death and the time of hematoma formation. Also presented in the book are possibilities of complex laser spectral photopolarimetry images of histological sections of biological tissues of human corpse in different spectral regions, with the simultaneous development and substantiation of a set of statistical and correlational criteria for objective determination of the time of death.

Correlation and Autofluorescence Microscopy in Forensics Medicine: Time of Death Detection Using Polycrystalline Cerebrospinal Fluid Films
Correlation and Autofluorescence Microscopy in Forensics Medicine: Time of Death Detection Using Polycrystalline Cerebrospinal Fluid Films

Author: M. S. Harazdyuk

Publisher: Springer Nature

Published: 2021

Total Pages: 73

ISBN-13: 9811601976

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This book highlights the first systematic synthesis of various research approaches in forensic medical diagnosis of the morphological and polycrystalline structure of human biological tissues and biological fluids. One of the global challenges in such diagnosis is the assessment of actual time of death. The relevance and objectivity of such studies are given by the innovative use of complex multifunctional methods using lasers and Mueller-matrix polarimetry, which is presented in this book. As a result, within the framework of the statistical, correlation and fractal approaches, diagnostic relationships were established between the time parameters of the transformation of the topographic structure of polarization-inhomogeneous microscopic images of biological preparations and necrotic changes in the morphological structure of biological tissues of the deceased. On this foundation, new forensic medicine criteria have been developed for objective determination of time of death.