Translational Urology

Translational Urology

Author: Anthony Atala

Publisher: Academic Press

Published: 2024-10-09

Total Pages: 518

ISBN-13: 0323901875

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Translational Urology covers the principles of evidence-based medicine and applies these principles to the design of translational investigations. The reader will come to fully understand important concepts, including case-control study, prospective cohort study, randomized trial, and reliability study. Medical researchers will benefit from greater confidence in their ability to initiate and execute their own investigations, avoid common pitfalls in urology, and know what is needed for successful collaboration. Further, this title is an indispensable tool in grant writing and funding efforts.This practical, straightforward approach helps the aspiring investigator navigate challenging considerations in study design and implementation. The book provides valuable discussions of the critical appraisal of published studies in urology, allowing the reader to learn how to evaluate the quality of such studies with respect to measuring outcomes and to make effective use of all types of evidence in patient care. - Focuses on the principles of evidence-based medicine and applies these principles to the design of translational investigations within the field of urology - Provides a practical, straightforward approach that helps investigators navigate challenging considerations in study design and implementation - Details discussions of the critical appraisal of published studies in urology, supporting evaluation with respect to measuring outcomes and making effective use of all types of evidence in patient care


Scientific Advances in Reconstructive Urology and Tissue Engineering

Scientific Advances in Reconstructive Urology and Tissue Engineering

Author: Matthias D. Hofer

Publisher: Academic Press

Published: 2022-03-31

Total Pages: 317

ISBN-13: 0323915205

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Scientific Advances in Reconstructive Urology and Tissue Engineering is a comprehensive overview of reconstructive urology that spans male and female, pediatric, neuro-urology and trauma. Traditionally, this field has been focused solely on surgical principles with little attention to basic and translational research. However, recent advances in acellular matrices, scaffolds, stem cells and tissue engineering have changed this focus. This publication is the perfect bridge and definitive tome of the advances that will move the translational and basic science of reconstructive urology forward and allow readers to implement the findings in clinical practice. Through the use of both current case studies and future implications, the content bridges the gap from bench to bedside making it the perfect reference for translational benign urology researchers who wish to move the field of reconstructive surgery forward. Includes real-world applications of current research to help readers get rapidly up-to-speed on which research results are appropriate for immediate implementation Presents the underlying mechanism of urologic disease processes pertinent to reconstructive urology for comprehensive understanding within the field Provides independent guidance to manage specific clinical conditions while also presenting approaches that are applicable to all conditions


Rare and Complex Urology

Rare and Complex Urology

Author: Jen Tidman

Publisher: Elsevier

Published: 2024-02-12

Total Pages: 354

ISBN-13: 0323999352

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Rare and Complex Urology combines information on clinical aspects, network developments and patient journeys in specific rare and complex urological diseases within the ERN (European Reference Network) template structure, allowing for better diagnosis, treatment and patient outcome. Each chapter contains an introduction on specific diseases with representative clinical images followed by a clinical view on treatment options (non-surgical and surgical) with clear schema and drawings; nurse specialist views on current care, patient views on the lifelong journey and expected development and research innovations for the future. Diseases covered include those of the bladder, stone and kidney diseases, malformations, pelvic floor disorders, the female urethra, reconstruction, surgery, cancers and rare tumors. This is a must have reference for basic scientists interested in engaging in translational urology and surgery and well as urologists seeking guidance on how to implement novel research. - Provides a foundation for many rare urogenital diseases and complex conditions with contributions from high-volume centres monitored by ERN eUROGEN - Combines in-depth research findings with clinical information to supply state-of-the-art care solutions for rare and complex aspects of urology - Removes the uncertainty of managing rare and complex urogenital cases and variations in practice


Performing the Penis

Performing the Penis

Author: Meredith Jones

Publisher: Taylor & Francis

Published: 2022-07-29

Total Pages: 175

ISBN-13: 1000618064

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This book will be the first collection that offers an overview and case studies around understandings and manifestations of penises and phalluses in the early twenty-first century. It examines how penises and phalluses are experienced and represented, drawing on examples from pornography, stripping, music video, film, surgery, and comedy. The penis—along with its twin the phallus—has been used to symbolise strength, fertility, and power but also bestiality, violence, and the ‘savage’. It has been worshipped, feared, and mocked. With contributing authors deploying conceptual frameworks based in philosophy, cultural studies, gender studies, affect theory, film theory, feminist theory, art theory, sociology, history, medical anthropology and media studies, this volume will appeal to a broad range of scholars and all who are interested in bodies, genitals, gender, and contemporary cultures.


Translational Urinomics

Translational Urinomics

Author: Hugo Miguel Baptista Carreira dos Santos

Publisher: Springer Nature

Published: 2021-05-06

Total Pages: 147

ISBN-13: 3030639088

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Translational Urinomics provides an overview of urine analysis using proteomics, metabolomics, transcriptomics or any combination thereof for the diagnosis and prognosis of diseases related to the urinary system and the kidneys. The text approaches urine biomarkers from a new perspective, incorporating up-to-date studies of mass-spectrometry-based biomarker discovery as well as the latest advances in personalized medicine. The integration of technology-driven techniques, such as OMICS also provides a unique opportunity for improved diagnostics accuracy of urinary-related diseases. For nephrologists and urologists looking for new approaches to well-known problems, this edited volume serves as a valuable guide.


Cancer Immunotherapy in Urology, An Issue of Urologic Clinics, E-Book

Cancer Immunotherapy in Urology, An Issue of Urologic Clinics, E-Book

Author: Sujit S Nair

Publisher: Elsevier Health Sciences

Published: 2020-10-15

Total Pages: 145

ISBN-13: 0323754996

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The Guest Editors of this issue of Urologic Clinics of North America have put together a comprehensive collection of articles that provides the current knowledge on urologic cancer immunotherapy. Expert authors have contributed clinical review articles on the following topics: Era of personalized vaccines for GU cancers; TCR and dendritic vaccine platforms for GU cancers; Neo-adjuvant platforms for GU cancer immunotherapy; Immune-editing in Cancer: Role of tumor microenvironment and immune-suppressive pathways in localized and aggressive disease; Clinical integration of neo-adjuvant platforms for prostate cancer immunotherapy; Immunotherapy for muscle and non-muscle invasive bladder cancer: BCG and beyond; Immunotherapy for metastatic bladder cancer; Immunotherapy options for metastatic castrate-resistant prostate cancer; Role of tissue infiltrating lymphocytes: Understanding TCR; Therapeutic platforms for IPSC-derived CAR-T; Immune-suppression in prostate cancer: Underlying causes and influence on response to immunotherapy; and Racial disparity in response to immunotherapy. Urologists will come away with the most current information they need to improve outcomes in the urologic cancer patient.


Neuro-Urology Research

Neuro-Urology Research

Author: Anne M.J. Verstegen

Publisher: Academic Press

Published: 2023-05-08

Total Pages: 260

ISBN-13: 0128224568

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**Selected for Doody's Core Titles® 2024 in Urology** Neuro-Urology Research: A Comprehensive Overview describes the current status of the neuro-urology field including the latest discoveries, explains in detail some of the neuroscience tools that can be used when studying the neural control of the lower urinary tract, and discusses potential future directions for research. The first section, Neuroscience in Urology Research, reviews neuro-regulators and the important anatomical brain sites. It also provides an overview of voluntary versus reflex micturition control and describes how bladder physiology readout is a useful tool in research. The second section, Fundamental and Translational Neuro-Urology Research, discusses the translational potential of basic research for patients and the impact of neuro-urology research on clinical practice. Chapters in this section provide more insight into pathologies endemic to specific patient populations and areas for treatment development opportunities. The third section, Neurobiological Tools Applied to Neuro-Urology Research, supplements the 'A Quick Guide to the "Neuroscience Toolbox"' and introduces research techniques such as RNA sequencing and calcium imaging of neural activity. The fourth and final section, aptly titled Research Directions and Research Opportunities, covers research directions that remain underexplored or have high therapeutic potential. Research in neuro-urology presents a route to understanding how bladder function is controlled and how urinary continence is maintained. This book provides a platform for researchers to initiate collaborations on the many underexplored research topics and to consolidate knowledge, ultimately lending itself to a coordinated and multi-center research approach that will benefit the field. - Presents a comprehensive overview of research studies in the field of neuro-urology - Discusses approaches to conducting neuro-urology research, including models of lower urinary tract dysfunction and methods of tracking bladder physiology - Proposes areas of research opportunity that, if explored, could yield effective treatment options for those affected by lower urinary tract disorders - Includes an introductory guide to useful research tools and the "Neuroscience Toolbox", as well as chapters specifically about RNA sequencing techniques and imaging bladder-associated neural circuits