This novel is set in the near future, where human genome editing has become routine. First adopted to fight a lethal virus, it is now widely used to prevent diseases and favor other traits. Ben, Eiko, Celia, Raphael and Leo have just had their coming-of-age genome reading and are struggling with this new information for each their own reasons. Soon, they are cast into the middle of a crisis that threatens the future of their society and pits it against a parallel, but strictly separated, society where genome manipulation is forbidden on religious grounds. The book includes an essay on the potential of human genome engineering and related genome-based choices.
Carolina Maria de Jesus' book, Quarto de Despejo (The Trash Room), depicted the harsh life of the slums, but it also spoke of the author's pride in her blackness, her high moral standards, and her patriotism. More than a million copies of her diary are believed to have been sold worldwide. Yet many Brazilians refused to believe that someone like de Jesus could have written such a diary, with its complicated words (some of them misused) and often lyrical phrasing as she discussed world events. Doubters prefer to believe the book was either written by Audáulio Dantas, the enterprising newspaper reporter who discovered her, or that Dantas rewrote it so substantially that her book is a fraud. With the cooperation of de Jesus' daughter, recent research shows that although Dantas deleted considerable portions of the diary (as well as a second one), every word was de Jesus'. But Dantas did "create" a different Carolina from the woman who coped with her harsh life by putting things down on paper. This book sets the record straight by providing detailed translations of de Jesus' unedited diaries and explains why Brazilian elites were motivated to obscure her true personality and present her as something she was not. It is not only about the writer but about Brazil as recorded by her sarcastic pen. The diary entries in this book span from 1958 to 1966, five years beyond text previously known to exist. They show de Jesus as she was, preserving her Joycean stream-of-consciousness language and her pithy characterizations.
We have taught plant molecular biology and biotechnology at the undergraduate and graduate level for over 20 years. In the past few decades, the field of plant organelle molecular biology and biotechnology has made immense strides. From the green revolution to golden rice, plant organelles have revolutionized agriculture. Given the exponential growth in research, the problem of finding appropriate textbooks for courses in plant biotechnology and molecular biology has become a major challenge. After years of handing out photocopies of various journal articles and reviews scattered through out the print and electronic media, a serendipitous meeting occurred at the 2002 IATPC World Congress held in Orlando, Florida. After my talk and evaluating several posters presented by investigators from my laboratory, Dr. Jacco Flipsen, Publishing Manager of Kluwer Publishers asked me whether I would consider editing a book on Plant Organelles. I accepted this challenge, after months of deliberations, primarily because I was unsuccessful in finding a text book in this area for many years. I signed the contract with Kluwer in March 2003 with a promise to deliver a camera-ready textbook on July 1, 2004. Given the short deadline and the complexity of the task, I quickly realized this task would need a co-editor. Dr. Christine Chase was the first scientist who came to my mind because of her expertise in plant mitochondria, and she readily agreed to work with me on this book.
CNS Neurotransmitters and Neuromodulators is an indispensable and comprehensive reference for any research worker involved with glutamate in the CNS. An impressive group of well-known authors contribute up-to-date reviews that offer a global picture of the state of research in the area. The authors cover a wide range of interdisciplinary aspects of the subject, including anatomical, physiological, and biochemical. Topics in this volume range from the localization of synthetic enzymes through electrophysiology, pharmacology, and molecular biology to behavioral importance in learning and memory. No other single volume offers the depth or broad scope of material found here. In addition to being a definitive reference work, CNS Neurotransmitters and Neuromodulators is the perfect one-step introduction to glutamate in the CNS for undergraduates, postgraduates, or established researchers who want a comprehensive overview text to keep abreast of developments in several areas of neuroscience.
William Shakespeare is viewed today as the quintessential English writer who has continued to influence art, poetry, philosophy and even science for over four centuries. His graphic imagery of Venice, Padua and Verona carefully braided with poignant tragic wreckages of real life circumstances, shrewdly infused with the ancient Kabbalah and transcendent Platonism was nothing short of genius. That is, if he ever put pen to paper! These chronicles reveal documentary evidence to confirm who really penned the Shakespearean canon. For centuries these works have been accoladed as the very basis of English literature, yet the author might not have been English at all! Amidst the mischief, mayhem and murder, these chronicles answer all the questions, including one of the greatest discoveries of all time - who owned the finest collection of Venetian, Italian and Byzantinian jewellery in the world - The Cheapside Hoard.
RNA Editing devotes a chapter to each of the major types of this form of RNA processing. Each chapter is written by a leader in the field and offers fundamental principles, as well as up to date information on recent advances. Numerous examples of RNAs known to be edited are provided throughout the volume, but most importantly, the book highlights the amazing mechanistic diversity found among the various types of RNA editing. RNAs are cleaved, ligated, and deaminated on their way to maturation, and in some cases, their sequence is even altered in the brief moment when RNA polymerase stalls. The chemical reactions that allow RNA editing, and the RNA and proteins that direct the process are all described and will be of interest to students and established researchers in the field as well as those scientists from other disciplines who come across examples of RNA editing.
An in-depth investigation of constraints on error variables in grammar with special reference to bilingual misspelling orthographies. A corpus of errors is examined in minute detail. In the course of this analysis, received categories and standard assumptions about linguistic errors are critically scrutinized; some are sharpened, and others are abandoned. Many conceptual snarls having to do with the notion of error in linguistic performance are untangled in this book.
