The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment

Author: Joerg Bluemel

Publisher: Academic Press

Published: 2015-03-13

Total Pages: 716

ISBN-13: 012417146X

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The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area. - Covers important topics such as species selection, study design, experimental methodologies, animal welfare and the 3Rs (Replace, Refine and Reduce), social housing, regulatory guidelines, comparative physiology, reproductive biology, genetic polymorphisms and more - Includes practical examples on techniques and methods to guide your daily practice - Offers a companion website with high-quality color illustrations, reference values for safety assessment and additional practical information such as study design considerations, techniques and procedures and dosing and sampling volumes


Monkeys on the Edge

Monkeys on the Edge

Author: Agustín Fuentes

Publisher: Cambridge University Press

Published: 2011-04-14

Total Pages: 381

ISBN-13: 1139500414

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Long-tailed macaques (Macaca fascicularis) have a wide geographical distribution and extensively overlap with human societies across southeast Asia, regularly utilizing the edges of secondary forest and inhabiting numerous anthropogenic environments, including temple grounds, cities and farmlands. Yet despite their apparent ubiquity across the region, there are striking gaps in our understanding of long-tailed macaque population ecology. This timely volume, a key resource for primatologists, anthropologists and conservationists, underlines the urgent need for comprehensive population studies on common macaques. Providing the first detailed look at research on this underexplored species, it unveils what is currently known about the population of M. fascicularis, explores the contexts and consequences of human-macaque sympatry and discusses the innovative programs being initiated to resolve human-macaque conflict across Asia. Spread throughout the book are boxed case studies that supplement the chapters and give a valuable insight into specific field studies on wild M. fascicularis populations.


Medical Primatology

Medical Primatology

Author: Eman P Fridman

Publisher: CRC Press

Published: 2002-03-14

Total Pages: 396

ISBN-13: 9780415275835

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Due to the high degree of biological similarity between primates and humans, monkeys and apes have been used successfully in medical research for many decades. Medical Primatology: History, Biological Foundations and Applications provides a comprehensive summary linking the use of monkeys and apes in biomedical research to their kinship with humans. The book begins by discussing the history of this research, and then focuses on the biological foundations upon which medical primatology has been built. Primate taxonomy and evolution are reviewed, using not only traditional sources of data, but also recent experimental evidence from molecular biology, genetics, and biomedicine that indicates the need to place higher simians in the family of man. Condensing a broad range of scientific literature into one volume, this will be a useful reference for specialists in the biological sciences and medicine, as well as researchers involved in biological, anthropological, biomedical, clinical, and pharmacological research on primates.


Faunal and Floral Migration and Evolution in SE Asia-Australasia

Faunal and Floral Migration and Evolution in SE Asia-Australasia

Author: Ian Metcalfe

Publisher: CRC Press

Published: 2001-06-01

Total Pages: 426

ISBN-13: 9789058093493

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This multidisciplinary book focuses on the relationships and interactions between palaeobiogeography, biogeography, dispersal, vicariance, migrations and evolution of organisms in the SE Asia-Australasian region. The book investigates biogeographic links between SE Asia and Australasia which go back more than 500 million years. It also focuses on the links between geological evolution and biological migrations and evolution in the region. It was in the SE Asian region that Alfred Russell Wallace established his biogeographic line, now known as Wallace's Line, which was the beginning of biogeography. Wallace also independently developed his theory of evolution based on his work in this area.;The book brings together, for the first time, geologists, palaeontologists, zoologists, botanists, entomologists, evolutionary biologists and archaeologists, in the one volume, to relate the region's geological past to its present biological peculiarities. The book is organized into six sections. Section 1 Paleobiogeographic Background provides overviews of the geological and tectonic evolution of SE Asia-Australasia, and changing patterns of land and sea for the last 540 million years. Section 2 Palaeozoic and Mesozoic Geology and Biogeography discusses Palaeozoic and Mesozoic biogeography of conodonts, brachiopods, plants, dinosaurs and radiolarians and the recognition of ancient biogeographic boundaries or Wallace Lines in the region. Section 3 Wallace's Line focuses on the biogeographic boundary established by Wallace, including the history of its establishment, its significance to biogeography in general and its applicability in the context of modern biogeography.;Section 4 Plant biogeography and evolution includes discussion on primitive angiosperms, the diaspora of the southern rushes, and environmental, climatic and evolutionary implications of plants and palynomorphs in the region. The biogeography and migration of insects, butterflies, birds, rodents and other non-primate mammals is discussed in section 5, Non Primates. The final section 6 Primates focuses on the biogeographic radiation, migration and evolution of primates and includes papers on the occurrence and migration of early hominids and the requirements for human colonization of Australia.