The Keller-Segel model for chemotaxis is a prototype of nonlocal systems describing concentration phenomena in physics and biology. While the two-dimensional theory is by now quite complete, the questions of global-in-time solvability and blowup characterization are largely open in higher dimensions. In this book, global-in-time solutions are constructed under (nearly) optimal assumptions on initial data and rigorous blowup criteria are derived.
The book will benefit a reader with a background in physical sciences and applied mathematics interested in the mathematical models of genetic evolution. In the first chapter, we analyze several thought experiments based on a basic model of stochastic evolution of a single genomic site in the presence of the factors of random mutation, directional natural selection, and random genetic drift. In the second chapter, we present a more advanced theory for a large number of linked loci. In the third chapter, we include the effect of genetic recombination into account and find out the advantage of sexual reproduction for adaptation. These models are useful for the evolution of a broad range of asexual and sexual populations, including virus evolution in a host and a host population.
This thesis is devoted to the analysis of singularities in nonlinear elliptic partial differential equations arising in mathematical physics, mathematical biology, and conformal geometry. The topics treated are the Ginzburg-Landau model of superconductivity, the Lin-Ni-Takagi problem, the Keller-Segel model of chemotaxis, and the prescribed scalar curvature problem. The Ginzburg-Landau model is a phenomenological description of superconductivity. An essential feature of type-II superconductors is the presence of vortices, which appear above a certain value of the strength of the applied magnetic field called the first critical field. We are interested in the regime of small epsilon, where epsilon is the inverse of the Ginzburg-Landau parameter (a material constant). In this regime, the vortices are at main order co-dimension 2 topological singularities. We provide a quantitative three-dimensional vortex approximation construction for the Ginzburg-Landau energy, which gives an approximation of vortex lines coupled to a lower bound for the energy, which is optimal to leading order and valid at the epsilon-level. By using these tools we then analyze the behavior of global minimizers below and near the first critical field. We show that below this critical value, minimizers of the Ginzburg-Landau energy are vortex-free configurations and that near this value, minimizers have bounded vorticity. The Lin-Ni-Takagi problem arises as the shadow of the Gierer-Meinhardt system of reaction-diffusion equations that models biological pattern formation. This problem is that of finding positive solutions of a critical equation in a bounded smooth three-dimensional domain, under zero Neumann boundary conditions. In this thesis, we construct solutions to this problem exhibiting single bubbling behavior at one point of the domain, as a certain parameter converges to a critical value. Chemotaxis is the influence of chemical substances in an environment on the movement of organisms. The Keller-Segel model for chemotaxis is an advection-diffusion system consisting of two coupled parabolic equations. Here, we are interested in radial steady states of this system. We are then led to study a critical equation in the two-dimensional unit ball, under zero Neumann boundary conditions. In this thesis, we construct several families of radial solutions which blow up at the origin of the ball and concentrate on the boundary and/or an interior sphere, as a certain parameter converges to zero. Finally, we study the prescribed scalar curvature problem. Given an n-dimensional compact Riemannian manifold, we are interested in finding bubbling metrics whose scalar curvature is a prescribed function, depending on a small parameter. We assume that this function has a critical point which satisfies a suitable flatness assumption. We construct several metrics, which blow-up as the parameter goes to zero, with prescribed scalar curvature.
This monograph is devoted to recent mathematical theories on the bottom up self-organization observed in closed and isolated thermo-dynamical systems. Its main features include:
Mean field approximation has been adopted to describe macroscopic phenomena from microscopic overviews. It is still in progress; fluid mechanics, gauge theory, plasma physics, quantum chemistry, mathematical oncology, non-equilibirum thermodynamics. spite of such a wide range of scientific areas that are concerned with the mean field theory, a unified study of its mathematical structure has not been discussed explicitly in the open literature. The benefit of this point of view on nonlinear problems should have significant impact on future research, as will be seen from the underlying features of self-assembly or bottom-up self-organization which is to be illustrated in a unified way. The aim of this book is to formulate the variational and hierarchical aspects of the equations that arise in the mean field theory from macroscopic profiles to microscopic principles, from dynamics to equilibrium, and from biological models to models that arise from chemistry and physics.
This open access book deals with a rich variety of taxis-type cross-diffusive equations. Particularly, it intends to show the key role played by quasi-energy inequality in the derivation of some necessary a priori estimates. This book addresses applied mathematics and all researchers interested in mathematical development of reaction-diffusion theory and its application and can be a basis for a graduate course in applied mathematics.
This book contains papers presented at the "Workshop on Singularities in PDE and the Calculus of Variations" at the CRM in July 2006. The main theme of the meeting was the formation of geometrical singularities in PDE problems with a variational formulation. These equations typically arise in some applications (to physics, engineering, or biology, for example) and their resolution often requires a combination of methods coming from areas such as functional and harmonic analysis, differential geometry and geometric measure theory. Among the PDE problems discussed were: the Cahn-Hilliard model of phase transitions and domain walls; vortices in Ginzburg-Landau type models for superconductivity and superfluidity; the Ohna-Kawasaki model for di-block copolymers; models of image enhancement; and Monge-Ampere functions. The articles give a sampling of problems and methods in this diverse area of mathematics, which touches a large part of modern mathematics and its applications.
* Examines a nonlinear system of parabolic PDEs arising in mathematical biology and statistical mechanics * Describes the whole picture, i.e., the mathematical and physical principles * Suitable for researchers and grad students in mathematics and applied mathematics who are interested in nonlinear PDEs in stochastic processes, cellular automatons, variational methods, and their applications to physics, chemistry, biology, and engineering
This volume is the proceedings of the 14th MSJ International Research Institute "Asymptotic Analysis and Singularity", which was held at Sendai, Japan in July 2005. The proceedings contain survey papers and original research papers on nonlinear partial differential equations, dynamical systems, calculus of variations and mathematical physics.Published by Mathematical Society of Japan and distributed by World Scientific Publishing Co. for all markets except North America
