Selenoprotein Structure and Function
Selenoprotein Structure and Function

Author:

Publisher: Academic Press

Published: 2022-01-28

Total Pages: 418

ISBN-13: 0323907369

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Selenoprotein Structure and Function, Volume 662 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this new release include Identification of Selenoprotein O substrates using a biotinylated ATP analog, Selenium-encoded isotopic signature targeted profiling, Designing tRNASec variants for efficient selenocysteine incorporation using Sec-specific reporters, Preparation of selenoprotein S by chemical ligation, Examining xCT-mediated selenium uptake and selenoprotein production capacity in cells, SecMS analysis of selenoprotein with selenocysteine insertion sequence and beyond, Selenocysteine substitutions in thiyl radical enzymes, and much more. Additional chapters cover Recombinant selenoprotein expression in E. coli based upon the redefinition of a UAG codon in an RF1-depleted host strain, Metabolic labeling with radioactive selenium in zebrafish, Low pH isoTOP-ABPP to identify selenocysteines, Expression of selenoproteins via genetic code expansion in mammalian cells, Alpha-methyl selenocysteine as a tool for the study of selenoproteins, Selective selenol fluorescent probes: design, synthesis, structural determinants, and biological applications, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Methods in Enzymology series - Updated release includes the latest information on Selenoprotein Structure and Function

Selenoprotein Structure and Function
Selenoprotein Structure and Function

Author: Eranthie Weerapana

Publisher: Elsevier

Published: 2022-02-04

Total Pages: 416

ISBN-13: 0323907350

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Examining xCT-mediated selenium uptake and selenoprotein production capacity in cells / Namgyu Lee, Anne E. Carlisle, and Dohoon Kim -- Methods for accurate and reproducible studies of pharmacological effects of selenium in cancer / Arun Kumar Selvam, Tímea Szekerczés, Sofia Björnstedt, Ali Razaghi, and Mikael Björnstedt -- Using selenocysteine-specific reporters to screen for efficient tRNASec variants / Christina Z. Chung, Dieter Söll, and Natalie Krahn -- Expressing recombinant selenoproteins using redefinition of a single UAG codon in an RF1-depleted E. coli host strain / Qing Cheng and Elias S.J. Arnér -- Selenocysteine substitutions in thiyl radical enzymes / Juan Carlos Cáceres, Clara A. Bailey, Kenichi Yokoyama, and Brandon L. Greene -- Expression of selenoproteins via genetic code expansion in mammalian cells / Jennifer C. Peeler and Eranthie Weerapana -- Applying selenocysteine-mediated expressed protein ligation to prepare the membrane enzyme selenoprotein S / Rujin Cheng, Jun Liu, Vidyadhar Daithankar, and Sharon Rozovsky -- Chemoproteomic interrogation of selenocysteine by low-pH isoTOP-ABPP / Daniel W. Bak and Eranthie Weerapana -- SecMS analysis of selenoproteins with selenocysteine insertion sequence and beyond / Chenfang Si, Ye Cao, and Yaoyang Zhang -- An accelerated and optimized algorithm of selenium-encoded isotopic signature targeted profiling for global selenoproteome analysis / Guogeng Jia, Jinjun Gao, Fan Yang, Tianyu Feng, and Chu Wang -- Assay of selenol species in biological samples by the fluorescent probe Sel-green / Baoxin Zhang and Jianguo Fang -- Identification of selenoprotein O substrates using a biotinylated ATP analog / Meghomukta Mukherjee and Anju Sreelatha -- Application of alpha-methyl selenocysteine as a tool for the study of selenoproteins / Emma J. Ste. Marie and Robert J. Hondal -- Modeling of selenocysteine-derived reactive intermediates utilizing a nano-sized molecular cavity as a protective cradle / Ryosuke Masuda and Kei Goto -- Diselenide-selenoester ligation in the chemical synthesis of proteins / Max J. Bedding, Sameer S. Kulkarni, and Richard J. Payne.

Protein Sensors and Reactive Oxygen Species
Protein Sensors and Reactive Oxygen Species

Author: Helmut Sies

Publisher: Academic Press

Published: 2002

Total Pages: 550

ISBN-13: 0121822486

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This volume of Methods in Enzymology is concerned with the rapidly developing field of selenoprotein synthesis and its related molecular genetics. Progressive information on the topics of proteins as redox sensors, selenoproteins, and the thioredoxin system is studied using methods such as bioinformatics, DNA chip technology, cell biology, molecular genetics, and enzymology. The information on novel selenoproteins identified from genomic sequence data, as well as current knowledge on glutathione peroxidases, selenoprotein P, iodothyronine deiodinases, and thioredoxin reductases, is presented in a method-based approach.

Selenium
Selenium

Author: Dolph L. Hatfield

Publisher: Springer Science & Business Media

Published: 2001

Total Pages: 350

ISBN-13: 9780792373353

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As discussed in this book, a large body of evidence indicates that selenium is a cancer chemopreventive agent. Further evidence points to a role of this element in reducing viral expression, in preventing heart disease, and other cardiovascular and muscle disorders, and in delaying the progression of AIDS in HIV infected patients. Selenium may also have a role in mammalian development, in male fertility, in immune function and in slowing the aging process. The mechanism by which selenium exerts its beneficial effects on health may be through selenium-containing proteins. Selenium is incorporated into protein as the amino acid selenocysteine. Selenocysteine utilizes a specific tRNA, a specific elongation factor, a specific set of signals, and the codeword, UGA, for its cotranslational insertion into protein. It is indeed the 21st naturally occurring amino acid to be incorporated into protein and marks the first and only expansion of the genetic code since the code was deciphered in the mid 1960s.

Trace Elements and Minerals in Health and Longevity
Trace Elements and Minerals in Health and Longevity

Author: Marco Malavolta

Publisher: Springer

Published: 2018-11-13

Total Pages: 332

ISBN-13: 3030037428

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This book describes the role of trace elements in health and longevity, pursuing a biogerontological approach. It offers essential information on the impact of trace elements on molecular and physiological processes of aging, and on their impact on health in connection with aging. The major topics covered in its 11 chapters, each dedicated to a specific trace element or mineral, are: a) Role of the element in species longevity, b) Recommended intake for longevity in animal species and in the elderly, c) Deficiency and age-related disease, d) Excess/toxicity and age-related disease, and e) Interactions with drugs prescribed in the elderly. Clinical, animal and other laboratory models of interest in aging are included, which enable a more in-depth analysis to be made. The respective chapters are a mixture of overviews and more in-depth reviews in which the mechanisms of aging are described from the point of view of their specific interactions with trace elements and minerals.

Selenium
Selenium

Author: Victor R Preedy

Publisher: Royal Society of Chemistry

Published: 2015-08-10

Total Pages: 667

ISBN-13: 1782622217

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Although toxic in large doses, selenium is an essential trace mineral in the animal diet and in some plants. It has a role in making antioxidant enzymes and a particular role in the functioning of the thyroid gland. This volume examines the chemical activity of selenium and its functional health effects eg towards cancers, in the heart and brain. It also covers other areas such as functional food enrichment, whole body metabolism, and the effects of selenium deficiency on health. Part of The Food and Nutritional Components in Focus series, this edited volume pools knowledge across scientific disciplines in a way that increases its applicability to a wide range of audiences. Victor Preedy’s own distinguished career in nutritional science has made him a prolific author of research articles and books in this area, and this project fills a gap in providing comprehensive synopses of food substances. Chemists, analytical scientists, forensic scientists, food scientists, as well as course lecturers will all benefit from this interdisciplinary title written by international experts in this area.

Mineral Containing Proteins
Mineral Containing Proteins

Author: Guanghua Zhao

Publisher: Springer

Published: 2017-03-03

Total Pages: 207

ISBN-13: 9811035962

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This book describes the structure, function and nutritional values of iron-, zinc-, selenium- and calcium-containing proteins, exploring key mineral-containing proteins like phytoferritin and lactoferrin, as well as a host of zinc- and selenium-containing proteins. Due to their role in numerous metabolic processes, minerals such as calcium, iron, zinc and selenium are vital, and have to be obtained from a balanced diet because they cannot be synthesized. The structure and function of mineral-containing proteins influences the absorption of these essential minerals. As such, the study of these proteins is crucial for the assessment and maintenance of a balanced diet and for the development of effective mineral supplements. The book’s closing chapters focus on issues arising from current food processing techniques and in the development of mineral supplements. The book offers a valuable guide for researchers and students in the fields of food chemistry and nutrition.

Selenium in Biology and Human Health
Selenium in Biology and Human Health

Author: Raymond F. Burk

Publisher: Springer

Published: 2011-10-04

Total Pages: 221

ISBN-13: 9781461225935

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Selenium plays a fascinating and still poorly understood role in the function of living cells and therefore in human health. Starting with investigations over 60 years ago into its role as a toxic agent in livestock disease, selenium studies have progressed rapidly with the application of tools from immunology and molecular biology. Selenium is now known to be important in human and animal nutrition, has been discovered as a structural component of so-called selenoproteins, and may play a number of physiological roles, ranging from cancer protection to hormone metabolism. Selenium in Biology and Human Health presents research syntheses on a range of topics involving selenium, written by specialists from around the world. It will be of interest to cell biologists and physiologists, nutritional scientists, and animal health researchers.

Selenium Contamination in Water
Selenium Contamination in Water

Author: Pooja Devi

Publisher: John Wiley & Sons

Published: 2021-05-12

Total Pages: 436

ISBN-13: 1119693543

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The contamination of environment and water resources by Selenium (Se) and its oxyanions from various sources are emerging contaminants of significant health and environmental concern. The primary sources include agricultural drainage water, mine drainage, residues from fossil fuels, thermoelectric power plants, oil refineries, and metal ores. Various methods and technologies have been developed which focus on the treatment of selenium-containing waters and wastewater. High concentrations of selenium in water cause various adverse impact to human health, such as carcinogenic, genotoxic, and cytotoxic effects. But in the lower concentrations, it is a useful constituent of the biological system. The range between toxicity and deficiency of selenium is minimal (40 to 400 μg per day), due to its dual nature. Selenium Contamination in Water contains the latest status and information on selenium’s origin, its chemistry and its toxicity to humans. The book represents a comprehensive and advanced reference book for students, researchers, practitioners, and policymakers in working in the field of metalloids, in particular selenium. A special emphasis is given on its geological distribution, monitoring techniques, and remedial technologies. As such, the authors critically analyze the various techniques used for the monitoring and removal of selenium from water. Featuring chapters arranged according to the major themes of the latest research, with specific case-studies from industrial experiences of selenium detection and removal, Selenium Contamination in Water will be particularly valued by researchers, practitioners, and policymakers in working in the field of metalloids including selenium.

Essentials of Medical Biochemistry
Essentials of Medical Biochemistry

Author: Chung Eun Ha

Publisher: Academic Press

Published: 2011-01-28

Total Pages: 600

ISBN-13: 0080916880

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Expert biochemist N.V. Bhagavan's new work condenses his successful Medical Biochemistry texts along with numerous case studies, to act as an extensive review and reference guide for both students and experts alike. The research-driven content includes four-color illustrations throughout to develop an understanding of the events and processes that are occurring at both the molecular and macrolecular levels of physiologic regulation, clinical effects, and interactions. Using thorough introductions, end of chapter reviews, fact-filled tables, and related multiple-choice questions, Bhagavan provides the reader with the most condensed yet detailed biochemistry overview available. More than a quick survey, this comprehensive text includes USMLE sample exams from Bhagavan himself, a previous coauthor. - Clinical focus emphasizing relevant physiologic and pathophysiologic biochemical concepts - Interactive multiple-choice questions to prep for USMLE exams - Clinical case studies for understanding basic science, diagnosis, and treatment of human diseases - Instructional overview figures, flowcharts, and tables to enhance understanding