Scale-up in Chemical Engineering

Scale-up in Chemical Engineering

Author: Marko Zlokarnik

Publisher: John Wiley & Sons

Published: 2006-08-21

Total Pages: 296

ISBN-13: 3527607765

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Covering the important task of the scale-up of processes from the laboratory to the production scale, this easily comprehensible and transparent book is divided into two sections. The first part details the theoretical principles, introducing the subject for readers without a profound prior knowledge of mathematics. It discusses the fundamentals of dimensional analysis, the treatment of temperature-dependent and rheological material values and scale-up where model systems or not available or only partly similar. All this is illustrated by 20 real-world examples, while 25 exercises plus solutions new to this edition practice and monitor learning. The second part presents the individual basic operations and covers the fields of mechanical, thermal, and chemical process engineering with respect to dimensional analysis and scale-up. The rules for scale-up are given and discussed for each operation. Other additions to this second edition are dimensional analysis of pelleting processes, and a historical overview of dimensional analysis and modeling, while all the chapters have been updated to take the latest literature into account. Written by a specialist with more than 40 years of experience in the industry, this book is specifically aimed at students as well as practicing engineers, chemists and process engineers already working in the field.


Dimensional Analysis and Scale-up in Chemical Engineering

Dimensional Analysis and Scale-up in Chemical Engineering

Author: Marko Zlokarnik

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 187

ISBN-13: 3642766730

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Contemporary Chemical Process Engineers face complex design and research problems. Temperature-dependent physical properties and non-Newtonian flow behavior of substances in a process cannot be predicted by numerical mathematics. Scaling-up equipment for processing can often only be done with partial similarity methods. Standard textbooks often neglect topics like dimensional analysis, theory of similarity and scale-up. This book fills this gap! It is aimed both at university students and the process engineer. It presents dimensional analysis very comprehensively with illustrative examples of mechanical, thermal and chemical processes.


Chemical Projects Scale Up

Chemical Projects Scale Up

Author: Joe M. Bonem

Publisher: Elsevier

Published: 2018-05-31

Total Pages: 234

ISBN-13: 0128137282

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Chemical Projects Scale Up: How to Go from Laboratory to Commercial covers the chemical engineering steps necessary for taking a laboratory development into the commercial world. The book includes the problems associated with scale up, equipment sizing considerations, thermal characteristics associated with scale up, safety areas to consider, recycling considerations, operability reviews and economic viability. In addition to the process design aspects of commercializing the laboratory development, consideration is given to the utilization of a development in an existing plant. - Explains how heat removal for exothermic reactions can be scaled up - Outlines how a reactor can be sized from batch kinetic data - Discusses how the plant performance of a new catalyst can be evaluated - Presents how the economics of a new product/process can be developed - Discusses the necessary evaluation of recycling in commercial plants


Scale-Up Processes

Scale-Up Processes

Author: Jamal Chaouki

Publisher: Walter de Gruyter GmbH & Co KG

Published: 2021-09-20

Total Pages: 350

ISBN-13: 3110713985

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Common scale-up methods are conventional where the blind piloting is essential. This imposes huge investment and leads to failures mostly in solid processing. However, the limitations of resources, current shortcomings, short time-to-market demand are forced companies to minimize piloting. With these situations in mind, current digitalization outlook and computational facilities, we proposed and developed a novel iterative scale up method with case studies which highly expedites the process innovation through the following key sequences:


Chemical Engineering in the Pharmaceutical Industry

Chemical Engineering in the Pharmaceutical Industry

Author: Mary T. am Ende

Publisher: John Wiley & Sons

Published: 2019-04-08

Total Pages: 1435

ISBN-13: 111928550X

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A guide to the important chemical engineering concepts for the development of new drugs, revised second edition The revised and updated second edition of Chemical Engineering in the Pharmaceutical Industry offers a guide to the experimental and computational methods related to drug product design and development. The second edition has been greatly expanded and covers a range of topics related to formulation design and process development of drug products. The authors review basic analytics for quantitation of drug product quality attributes, such as potency, purity, content uniformity, and dissolution, that are addressed with consideration of the applied statistics, process analytical technology, and process control. The 2nd Edition is divided into two separate books: 1) Active Pharmaceutical Ingredients (API’s) and 2) Drug Product Design, Development and Modeling. The contributors explore technology transfer and scale-up of batch processes that are exemplified experimentally and computationally. Written for engineers working in the field, the book examines in-silico process modeling tools that streamline experimental screening approaches. In addition, the authors discuss the emerging field of continuous drug product manufacturing. This revised second edition: Contains 21 new or revised chapters, including chapters on quality by design, computational approaches for drug product modeling, process design with PAT and process control, engineering challenges and solutions Covers chemistry and engineering activities related to dosage form design, and process development, and scale-up Offers analytical methods and applied statistics that highlight drug product quality attributes as design features Presents updated and new example calculations and associated solutions Includes contributions from leading experts in the field Written for pharmaceutical engineers, chemical engineers, undergraduate and graduation students, and professionals in the field of pharmaceutical sciences and manufacturing, Chemical Engineering in the Pharmaceutical Industry, Second Edition contains information designed to be of use from the engineer's perspective and spans information from solid to semi-solid to lyophilized drug products.


Scaleup of Chemical Processes

Scaleup of Chemical Processes

Author: Attilio Bisio

Publisher: Wiley-Interscience

Published: 1985-07-25

Total Pages: 760

ISBN-13:

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The focus of this book is on the technical factors that are critical to th e design and startup of a commercial manufacturing facility.


Scaling Chemical Processes

Scaling Chemical Processes

Author: Jonathan Worstell

Publisher: Butterworth-Heinemann

Published: 2016-06-08

Total Pages: 187

ISBN-13: 0128047690

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Scaling Chemical Processes: Practical Guides in Chemical Engineering is one of a series of short texts that each provides a focused introductory view on a single subject. The full library spans the main topics in the chemical process industries for engineering professionals who require a basic grounding in various related topics. They are 'pocket publications' that the professional engineer can easily carry with them or access electronically while working. Each text is highly practical and applied, and presents first principles for engineers who need to get up to speed in a new area fast. The focused facts provided in each guide will help you converse with experts in the field, attempt your own initial troubleshooting, check calculations, and solve rudimentary problems. This book discusses scaling chemical processes from a laboratory through a pilot plant to a commercial plant. It bases scaling on similarity principles and uses dimensional analysis to derive the dimensionless parameters necessary to ensure a successful chemical process development program. This series is fully endorsed and co-branded by the IChemE, and they help to promote the series. - Offers practical, short, concise information on the basics to help you get an answer or teach yourself a new topic quickly - Includes industry examples to help you solve real world problems - Provides key facts for professionals in convenient single subject volumes - Discusses scaling chemical processes from a laboratory through a pilot plant to a commercial plant


Handbook of Transition Metal Polymerization Catalysts

Handbook of Transition Metal Polymerization Catalysts

Author: Ray Hoff

Publisher: John Wiley & Sons

Published: 2018-04-20

Total Pages: 895

ISBN-13: 1119242215

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Including recent advances and historically important catalysts, this book overviews methods for developing and applying polymerization catalysts – dealing with polymerization catalysts that afford commercially acceptable high yields of polymer with respect to catalyst mass or productivity. • Contains the valuable data needed to reproduce syntheses or use the catalyst for new applications • Offers a guide to the design and synthesis of catalysts, and their applications in synthesis of polymers • Includes the information essential for choosing the appropriate reactions to maximize yield of polymer synthesized • Presents new chapters on vanadium catalysts, Ziegler catalysts, laboratory homopolymerization, and copolymerization


Industrial Process Scale-up

Industrial Process Scale-up

Author: Jan Harmsen

Publisher: Elsevier

Published: 2013-04-25

Total Pages: 129

ISBN-13: 0444627391

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This book will help industrial process innovators in research, development and commercial start-up to assess the risks of commercial-scale implementation and provide them with practical guidelines and methods to reduce the risks to acceptable levels. The book can also be used in co-operation with industrial R&D people and academic researchers to shape open innovation programs and in education as a reference book for process innovation courses. - Offers easily accessible, step-by-step, and concise guidelines for industrial process scale-up - Explains each stage of the innovation funnel: research, development, demonstration, commercial implementation for any process type and branch - Based on industrial experiences and practices, which reduces the risks of commercial scale implementation of new processes to acceptable levels and reduces cost and time of process innovation - Very clear, attractive layout, using text boxes that contain clarifying notes and additional information on specific topics, which makes it a quick reference of main subjects and additional information