Microemulsions as stepping stones to greener organic chemistry

Microemulsions as stepping stones to greener organic chemistry

Author: Nadja Wulff

Publisher: Cuvillier Verlag

Published: 2015-01-16

Total Pages: 166

ISBN-13: 373694909X

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In organic chemistry the simultaneous solubility of hydrophobic and hydrophilic reactants in a common solvent is an ubiquitous problem. Often either an expensive or a toxic solvent is needed. Alternatively, polar and non polar components are mixed into macroemulsions permitting them to react across the internal interface. However, macroemulsions display a comparatively small interfacial area. Thus, the reaction rate is low. Microemulsions feature an inherent vast interfacial area which facilitates significantly higher reaction rates. Furthermore, they allow a rather simple monitoring of the reaction kinetics by observing changes in the phase behavior. In this work the advantages of microemulsions as efficient reaction media for the photochemically induced Paternò Büchi reaction of pyruvic acid and 1 octene are elucidated. The amphiphilic reaction product 3 hexyl 2 methyloxetane 2 carboxylic acid influences the phase behavior of the microemulsion system significantly. With increasing UV exposure time the point of highest efficiency was shifted to lower temperatures and, interestingly, an increase of efficiency was detected. Hence, the newly created amphiphile acts as an efficient, hydrophobic cosurfactant. Additionally, with small angle neutron scattering and freeze fracture electron microscopy it was shown that the bicontinuous microstructure survives the UV irradiation. Another route towards green organic chemistry was opened by characterization of two new sustainable biosurfactants (mannosylerythritollipids (MEL) and cellobioselipids (CL)) in microemulsions.


Aulton's Pharmaceutics

Aulton's Pharmaceutics

Author: Michael E. Aulton

Publisher: Elsevier Health Sciences

Published: 2013

Total Pages: 909

ISBN-13: 0702042900

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"Pharmaceutics is the art of pharmaceutical preparations. It encompasses design of drugs, their manufacture and the elimination of micro-organisms from the products. This book encompasses all of these areas."--Provided by publisher.


Handbook of Formulating Dermal Applications

Handbook of Formulating Dermal Applications

Author: Nava Dayan

Publisher: John Wiley & Sons

Published: 2016-12-07

Total Pages: 701

ISBN-13: 1119364248

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The conceptualization and formulation of skin care products intended for topical use is a multifaceted and evolving area of science. Formulators must account for myriad skin types, emerging opportunities for product development as well as a very temperamental retail market. Originally published as "Apply Topically" in 2013 (now out of print), this reissued detailed and comprehensive handbook offers a practical approach to the formulation chemist's day-to-day endeavors by: Addressing the innumerable challenges facing the chemist both in design and at the bench, such as formulating with/for specific properties; formulation, processing and production techniques; sensory and elegancy; stability and preservation; color cosmetics; sunscreens; Offering valuable guidance to troubleshooting issues regarding ingredient selection and interaction, regulatory concerns that must be addressed early in development, and the extrapolation of preservative systems, fragrances, stability and texture aids; Exploring the advantages and limitations of raw materials; Addressing scale-up and pilot production process and concerns; Testing and Measurements Methods. The 22 chapters written by industry experts such as Roger L. McMullen, Paul Thau, Hemi Nae, Ada Polla, Howard Epstein, Joseph Albanese, Mark Chandler, Steve Herman, Gary Kelm, Patricia Aikens, and Sam Shefer, along with many others, give the reader and user the ultimate handbook on topical product development.


Fundamentals of Enzyme Engineering

Fundamentals of Enzyme Engineering

Author: Young Je Yoo

Publisher: Springer

Published: 2017-01-12

Total Pages: 208

ISBN-13: 9402410260

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This book provides a comprehensive introduction to all aspects of enzyme engineering, from fundamental principles through to the state-of-the-art in research and industrial applications. It begins with a brief history, describing the milestones of advancement in enzyme science and technology, before going on to cover the fundamentals of enzyme chemistry, the biosynthesis of enzymes and their production. Enzyme stability and the reaction kinetics during enzymatic reactions are presented to show how enzymes function during catalysis and the factors that affect their activity. Methods to improve enzyme performance are also presented, such as cofactor regeneration and enzyme immobilization. The book emphasizes and elaborates on the performance and characteristics of enzymes at the molecular level. Finally, the book presents recent advances in enzyme engineering and some key industrial application of enzymes addressing the present needs of society. This book presents essential information not only for undergraduate and graduate students, but also for researchers in academia and industry, providing a valuable reference for the development of commercial applications of enzyme technology.


Strategies to Modify the Drug Release from Pharmaceutical Systems

Strategies to Modify the Drug Release from Pharmaceutical Systems

Author: Marcos Luciano Bruschi

Publisher: Woodhead Publishing

Published: 2015-06-16

Total Pages: 208

ISBN-13: 0081001126

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Since the earliest dosage forms to modern drug delivery systems, came a great development and growth of knowledge with respect to drug delivery. Strategies to Modify the Drug Release from Pharmaceutical Systems will address principles, systems, applications and advances in the field.It will be principally a textbook and a reference source of strategies to modify the drug release. Moreover, the characterization, mathematical and physicochemical models, applications and the systems will be discussed. - Addresses the principles, systems, applications and advances in the field of drug delivery - Highlights the mathematical and physicochemical principles related to strategies - Discusses drug release and its possible modifications


Pharmaceutical Manufacturing Handbook

Pharmaceutical Manufacturing Handbook

Author: Shayne Cox Gad

Publisher: John Wiley & Sons

Published: 2008-03-21

Total Pages: 1384

ISBN-13: 0470259809

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This handbook features contributions from a team of expert authors representing the many disciplines within science, engineering, and technology that are involved in pharmaceutical manufacturing. They provide the information and tools you need to design, implement, operate, and troubleshoot a pharmaceutical manufacturing system. The editor, with more than thirty years' experience working with pharmaceutical and biotechnology companies, carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear.


Omega-3 Delivery Systems

Omega-3 Delivery Systems

Author: Pedro J. García-Moreno

Publisher: Academic Press

Published: 2021-07-25

Total Pages: 508

ISBN-13: 0128230274

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Omega-3 Delivery Systems: Production, Physical Characterization and Oxidative Stability offers the most recent updates for developing, characterizing, and stabilizing both traditional and novel omega-3 delivery systems, including their final incorporation into food matrices and physicochemical changes during digestion. The book brings chapters on novel omega-3 delivery systems (e.g., high-fat emulsions, Pickering emulsions, electrosprayed capsules, and solid lipid nanoparticles), the application of advanced techniques to evaluate physical and oxidative stabilities (e.g., SAXS, SANS, ESR, and super-resolution fluorescence microscopy), and new developments of food enrichment and physicochemical changes during digestion. The book provides a unique multidisciplinary and multisectoral approach, i.e., featuring authors from industry and academy. Long chain omega-3 polyunsaturated fatty acids (PUFA) present numerous health benefits; however, the consumption of natural products rich in omega-3 PUFA (e.g., fish, krill, and algae) is not enough to reach the daily-recommended values. Therefore, the food industry is highly interested in producing omega-3 fortified foods. - Brings a holistic approach of omega-3 delivery systems, bringing scientific understanding on production, physical characterization, and oxidative stability - Covers key aspects to develop, characterize, and use omega-3 delivery systems for food enrichment, considering physicochemical changes occurring during digestion - Serves as an interface between lipid oxidation and colloids chemistry, encapsulation techniques, soft matter physics, food development, and nutrients bioavailability


Active Protective Coatings

Active Protective Coatings

Author: Anthony E. Hughes

Publisher: Springer

Published: 2016-03-01

Total Pages: 429

ISBN-13: 9401775400

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This book covers a broad range of materials science that has been brought to bear on providing solutions to the challenges of developing self-healing and protective coatings for a range of metals. The book has a strong emphasis on characterisation techniques, particularly new techniques that are beginning to be used in the coatings area. It features many contributions written by experts from various industrial sectors which examine the needs of the sectors and the state of the art. The development of self-healing and protective coatings has been an expanding field in recent years and applies a lot of new knowledge gained from other fields as well as other areas of materials science to the development of coatings. It has borrowed from fields such as the food and pharmaceutical industries who have used, polymer techniques, sol-gel science and colloidosome technology for a range encapsulation techniques. It has also borrowed from fields like hydrogen storage such as from the development of hierarchical and other materials based on organic templating as “nanocontainers” for the delivery of inhibitors. In materials science, recent developments in high throughput and other characterisation techniques, such as those available from synchrotrons, are being increasing used for novel characterisation – one only needs to look at the application of these techniques in self healing polymers to gauge wealth of new information that has been gained from these techniques. This work is largely driven by the need to replace environmental pollutants and hazardous chemicals that represent risk to humans such as chromate inhibitors which are still used in some applications.


Physical Chemistry of Foods

Physical Chemistry of Foods

Author: Pieter Walstra

Publisher: CRC Press

Published: 2002-10-08

Total Pages: 834

ISBN-13: 9780203910436

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Exploring the structure and physical and chemical properties of solutions, dispersions, soft solids, fats, and cellular systems, Physical Chemistry of Foods describes the physiochemical principles of the reactions and conversions that occur during the manufacture, handling, and storage of foods. Coverage progresses from aspects of thermodynamics, bonds and interaction forces, and reaction kinetics, to transport phenomena, polymers, colloidal interactions, nucleation, glass transitions and freezing, and soft solids. This comprehensive volume effectively clarifies the physicochemical processes encountered in food product development.