Profiles of Drug Substances, Excipients and Related Methodology

Profiles of Drug Substances, Excipients and Related Methodology

Author: Harry G. Brittain

Publisher: Academic Press

Published: 2012-05-09

Total Pages: 483

ISBN-13: 0123977568

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Volumes in this widely revered series present comprehensive reviews of drug substances and additional materials, with critical review chapters that summarize information related to the characterization of drug substances and excipients. This organizational structure meets the needs of the pharmaceutical community and allows for the development of a timely vehicle for publishing review materials on this topic. The scope of the Profiles series encompasses review articles and database compilations that fall within one of the following six broad categories: Physical profiles of drug substances and excipients; Analytical profiles of drug substances and excipients; Drug metabolism and pharmacokinetic profiles of drug substances and excipients; Methodology related to the characterization of drug substances and excipients; Methods of chemical synthesis; and Reviews of the uses and applications for individual drug substances, classes of drug substances, or excipients. - Contributions from leading authorities - Informs and updates on all the latest developments in the field


Correlations Between Levels for Stellar-scintillometer-derived Profiles of C2n

Correlations Between Levels for Stellar-scintillometer-derived Profiles of C2n

Author: Frank P. Battles

Publisher:

Published: 1990

Total Pages: 34

ISBN-13:

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A stellar scintillometer measures the variance of stellar intensity for a first magnitude or greater star. This variance can be converted, by the use of spatial filters, into a profile of (c sub n) -sq, the index of refraction structure constant, for 7 different altitudes or levels. The (c sub n) -sq values are not entirely instrument independent because there will be some overlap in the weighting functions used to separate the spatial frequencies. It is usually assumed that readings from levels 1, 4, and 7 are instrument independent. When linear correlation coefficients are calculated between levels for (c sub n) -sq and Log (c sub n) -sq of this data set, results obtained seem to contradict the above stated assumption. Much less correlation is observed when calculated on a nightly basis. In fact, some nightly coefficients are significantly negative, which could not be due to weighting function overlap. We have investigated other mechanisms which could lead to a high degree of correlation across the entire data set. During the measurement program, atmospheric conditions changed from evening to evening. For example, the jet stream passed through several times affecting the entire altitude range of the scintillometer. Correlation studies do not indicate that, except for low lying adjacent levels, (c sub n) -sq values obtained using the scintillometer are instrument dependent.