Power-Loss Optimized Field-Free Line Generation for Magnetic Particle Imaging
Power-Loss Optimized Field-Free Line Generation for Magnetic Particle Imaging

Author: Matthias Weber

Publisher:

Published: 2015-08-31

Total Pages: 82

ISBN-13: 9783945954065

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Magnetic Particle Imaging (MPI) is a novel medical imaging technology that is able to acquire the distribution of superparamagnetic iron oxide nanoparticles in real-time with high spatial and temporal resolution. Spatial encoding is realized by a magnetic field configuration generating a field-free point (FFP). Therefore, the FFP is moved through the field of view (FOV). However, at low particle concentrations the signal-to-noise ratio (SNR) decreases and therefore image quality worsens. An enhanced encoding scheme uses instead of the FFP the concept of a field-free line (FFL), whereby a gain of sensitivity of one order of magnitude can be realized. Simulation studies approximate power consumption to a minimum and improve field homogeneity with the result that fast Radon-based reconstruction techniques are feasible. On the basis of these studies, this book describes the manufacturing of an optimized scanner topology realizing an excellent field quality with the help of customized curved rectangular coils. Furthermore, the power loss is efficiently minimized.

Field Free Line Magnetic Particle Imaging
Field Free Line Magnetic Particle Imaging

Author: Marlitt Erbe

Publisher: Springer Science & Business Media

Published: 2014-03-12

Total Pages: 175

ISBN-13: 3658053372

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Marlitt Erbe provides a detailed introduction into the young research field of Magnetic Particle Imaging (MPI) and field free line (FFL) imaging in particular. She derives a mathematical description of magnetic field generation for FFL imaging in MPI. To substantiate the simulation studies on magnetic FFL generation with a proof-of-concept, the author introduces the FFL field demonstrator, which provides the world’s first experimentally generated rotated and translated magnetic FFL field complying with the requirements for FFL reconstruction. Furthermore, she proposes a scanner design of considerably enhanced magnetic field quality and efficiency. The author discusses the influence of magnetic field quality optimization on the image quality achieved using efficient Radon-based reconstruction methods, which arise for a line detection scheme and based on this optimized design, presents a dynamic FFL scanner assembly.

Magnetic Particle Imaging
Magnetic Particle Imaging

Author: Thorsten M. Buzug

Publisher: Springer Science & Business Media

Published: 2012-02-28

Total Pages: 345

ISBN-13: 3642241336

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Magnetic Particle Imaging (MPI) is a novel imaging modality. In MPI superparamagnetic iron oxide nanoparticles are used as tracer materials. The volume is the proceeding of the 2nd international workshop on magnetic particle imaging (IWMPI). The workshop aims at covering the status and recent developments of both, the instrumentation and the tracer material, as each of them is equally important in designing a well performing MPI. For instance, the current state of the art in magnetic coil design for MPI is discussed. With a new symmetrical arrangement of coils, a field-free line (FFL) can be produced that promises a significantly higher sensitivity compared with the standard arrangement for a FFP. Furthermore, the workshop aims at presenting results from phantom and pre-clinical studies.

Magnetic Particle Imaging
Magnetic Particle Imaging

Author: Tobias Knopp

Publisher: Springer Science & Business Media

Published: 2012-05-04

Total Pages: 211

ISBN-13: 364204199X

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This volume provides a comprehensive overview of recent developments in magnetic particle imaging (MPI), a novel imaging modality. Using various static and oscillating magnetic fields, and tracer materials made from iron oxide nanoparticles, MPI can perform background-free measurements of the particles’ local concentration. The method exploits the nonlinear remagnetization behavior of the particles and has the potential to surpass current methods for the detection of iron oxide in terms of sensitivity and spatiotemporal resolution. Starting from an introduction to the technology, the topics addressed include setting up an imaging device, assessment of image quality, development of new MPI tracer materials, and the first preclinical results. This is the first book to be published on magnetic particle imaging, and it will be an invaluable source of information for everyone with an interest in this exciting new modality.

Nanomedicine - Basic and Clinical Applications in Diagnostics and Therapy
Nanomedicine - Basic and Clinical Applications in Diagnostics and Therapy

Author: C. Alexiou

Publisher: Karger Medical and Scientific Publishers

Published: 2011-10-06

Total Pages: 211

ISBN-13: 380559819X

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Nanomedicine - the application of nanotechnology to human health - is a promising field of research at the interface of physical, chemical, biological, and medical science. Recent advances have made it possible to analyze biological systems at cellular and subcellular levels, offering numerous promising approaches to improve medical diagnosis and therapy. It is expected that nanomedicine will have a great impact especially on drug delivery and imaging. In this context, the development of targeted, highly specific nanoparticles is of pivotal importance. The results of these advances will offer personalized diagnostic tools and treatments in the future. Based on the 2nd Else Kröner-Fresenius-Symposium, this book presents a broad spectrum of topics ranging from nanoscale drug delivery/drug design to nanotoxicity and from diagnostics and imaging to therapeutic applications including antibody therapies. The contributions are authored by leading experts in the field and provide an excellent overview of the current knowledge in nanomedicine. Due to the interdisciplinary nature of the subject area this volume will be of special interest to physicians, biologists, chemists, engineers, and physicists as well as to students in the respective fields.

Fundamentals of Electric Propulsion
Fundamentals of Electric Propulsion

Author: Dan M. Goebel

Publisher: John Wiley & Sons

Published: 2008-12-22

Total Pages: 528

ISBN-13: 0470436263

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Throughout most of the twentieth century, electric propulsion was considered the technology of the future. Now, the future has arrived. This important new book explains the fundamentals of electric propulsion for spacecraft and describes in detail the physics and characteristics of the two major electric thrusters in use today, ion and Hall thrusters. The authors provide an introduction to plasma physics in order to allow readers to understand the models and derivations used in determining electric thruster performance. They then go on to present detailed explanations of: Thruster principles Ion thruster plasma generators and accelerator grids Hollow cathodes Hall thrusters Ion and Hall thruster plumes Flight ion and Hall thrusters Based largely on research and development performed at the Jet Propulsion Laboratory (JPL) and complemented with scores of tables, figures, homework problems, and references, Fundamentals of Electric Propulsion: Ion and Hall Thrusters is an indispensable textbook for advanced undergraduate and graduate students who are preparing to enter the aerospace industry. It also serves as an equally valuable resource for professional engineers already at work in the field.