Phytochemicals as Lead Compounds for New Drug Discovery
Phytochemicals as Lead Compounds for New Drug Discovery

Author: Chukwuebuka Egbuna

Publisher: Elsevier

Published: 2019-09-07

Total Pages: 382

ISBN-13: 0128178914

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Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases. Written by a global team of experts, Phytochemicals as Lead Compounds for New Drug Discovery is an ideal resource for drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists, analytical chemists, and other researchers in those fields. It will also be very valuable to professors, students, and researchers in this domain. - Presents fundamental concepts and factors affecting choice for plant-based products - Details the FDA drug candidacy acceptance criteria, including bottlenecks and way forward - Highlights recent advances in computational-based drug discovery - Focuses on the discovery of new drugs and potential druggable targets for the treatment of chronic diseases of world importance

Plants For Novel Drug Molecules
Plants For Novel Drug Molecules

Author: Bikarma Singh

Publisher: New India Publishing Agency

Published: 2020-11-24

Total Pages: 8

ISBN-13: 9389571944

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The present book is based on twenty five excellent scientific contributions of seventy researchers from topmost research organizations. The book begin with plants used in Sowa-Rigpa system of food and medicine, followed by traditional uses of plants as medicine among Khasi tribe living in northeast India. This compilation contains several research techniques highlighting methods and analysis of documented data, and procedure for scientific validation of findings. Methods for assessing traditional knowledge of highly threatened plants such as Hodgsoniaheteroclita, pharmacological applications of family asteraceae, ethnobotany of family apiaceae, plants used in managing leucorrhea, plants as animal care, phytochemistry of Arisaemajacquemontii, Andrographispaniculata, Blumealacera, Boerhaaviadiffusa, Hemidesmusindicus, Pterocarpussantalinus, Rauwolfiaserpentina, Rauwolfiatetraphylla, and several other ethnobotanical and ethnopharmacological parameters used in studying current science is described in this book. Besides, it is followed by several research topics focused to the clinical arena, plants used in relation to cancer, diabetes, skin disorders and many other aspects relates to animal and human health care. Today's food supplements derived from plants are of high demand, and this compilation also highlighted several plants used as nutraceuticals. It has been observed that herbs contain many bioactive compounds with powerful antioxidant properties as evidence from the scientific data, and few research on lianas, lichens and role of allylisothiocyanate as a bioprotective agent also discussed added more value to this compilations. Focused theme such as ethnobotanical trends and techniques, phytochemistry, biological activities, ethnopharmacology and clinical studies is adding and contributing a lots value to this book in discovering leads for medicine formulations.

New Look to Phytomedicine
New Look to Phytomedicine

Author: Mohd Sajjad Ahmad Khan

Publisher: Academic Press

Published: 2018-10-23

Total Pages: 711

ISBN-13: 0128146206

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New Look to Phytomedicine: Advancements in Herbal Products as Novel Drug Leads is a compilation of in-depth information on the phytopharmaceuticals used in modern medicine for the cure and management of difficult-to-treat and challenging diseases. Readers will find cutting-edge knowledge on the use of plant products with scientific validation, along with updates on advanced herbal medicine in pharmacokinetics and drug delivery. This authoritative book is a comprehensive collection of research based, scientific validations of bioactivities of plant products, such as anti-infective, anti-diabetic, anti-cancer, immune-modulatory and metabolic disorders presented by experts from across the globe. Step-by-step information is presented on chemistry, bioactivity and the functional aspects of biologically active compounds. In addition, the pharmacognosy of plant products with mechanistic descriptions of their actions, including pathogenicity is updated with information on the use of nanotechnology and molecular tools in relation to herbal drug research. - Compiles up-to-date information on the chemotherapeutics used in the treatment of infective and metabolic disorders - Presents advancements in the discovery of new drugs from plants using molecular and nanotechnology tools - Examines detailed information on the use of herbals agents in cancer, HIV and other ailments, including diabetes, malaria and neurological disorders

Biodiversity
Biodiversity

Author: National Academy of Sciences/Smithsonian Institution

Publisher: National Academies Press

Published: 1988-01-01

Total Pages: 535

ISBN-13: 0309037395

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This important book for scientists and nonscientists alike calls attention to a most urgent global problem: the rapidly accelerating loss of plant and animal species to increasing human population pressure and the demands of economic development. Based on a major conference sponsored by the National Academy of Sciences and the Smithsonian Institution, Biodiversity creates a systematic framework for analyzing the problem and searching for possible solutions.

Synthesis of Medicinal Agents from Plants
Synthesis of Medicinal Agents from Plants

Author: Ashish Tewari

Publisher: Elsevier

Published: 2018-04-17

Total Pages: 384

ISBN-13: 0081022743

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Synthesis of Medicinal Agents from Plants highlights the importance of synthesizing medicinal agents from plants and outlines methods for performing it effectively. Beginning with an introduction to the significance of medicinal plants, the book goes on to provide a historical overview of drug synthesis before exploring how this can be used to successfully replicate and adapt the active agents from natural sources. Chapters then explore the medicinal properties of a number of important plants, before concluding with a discussion of the future of drugs from medicinal plants. Illustrated with real-world examples, it is a practical resource for researchers in this field. In an age of rapid environmental destruction, hundreds of medicinal plants are at risk of extinction from overexploitation and deforestation, limiting the natural resources available for active agent extraction, thereby threatening the discovery of future cures for diseases. Simultaneously, with the increasing population and advances in medical sciences, the demand for drugs is continuously increasing and cannot be met with just plants. The ability to synthetically replicate the active compounds from these plants is essential in creating an ecologically-aware, sustainable future for drug design - Includes detailed coverage of therapeutic compound synthesis - Uses multiple real-world examples to support content - Lays out a sustainable template for the future of developing active agents from natural products

Lead Molecules from Natural Products
Lead Molecules from Natural Products

Author:

Publisher: Elsevier

Published: 2006-07-07

Total Pages: 449

ISBN-13: 0080459331

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Lead Molecules from Natural Products: Discovery and New Trends provides the reader with a thorough overview of current discoveries and trends in Natural Products research. This book consists of 22 chapters from well known scientists all over the world, with topics ranging from Natural Product Chemistry and Phytochemistry in their most basic form, to Molecular Biology and in silico drug design. Contributors describe their own laboratory experiences, revealing their findings, the legal issues encountered.The chapters, all of equally high quality, summarize years of extensive research in each area, and provide insight in the new themes of natural product research. The information will help to predict promising leads, useful for physicians in the treatment of different diseases and disease manifestations.* Explains the effects of plant extracts on gene expression profiling. * Details medicinal plant research from around the world* Explores a variety of medicinal uses of plants from traditional remedies, to anti-cancer agents and anti-salmonella agents.

Medicinal Plants
Medicinal Plants

Author: Da-Cheng Hao

Publisher: Woodhead Publishing

Published: 2015-06-29

Total Pages: 694

ISBN-13: 0081001037

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Medicinal Plants: Chemistry, Biology and Omics reviews the phytochemistry, chemotaxonomy, molecular biology, and phylogeny of selected medicinal plant tribes and genera, and their relevance to drug efficacy. Medicinal plants provide a myriad of pharmaceutically active components, which have been commonly used in traditional Chinese medicine and worldwide for thousands of years. Increasing interest in plant-based medicinal resources has led to additional discoveries of many novel compounds, in various angiosperm and gymnosperm species, and investigations on their chemotaxonomy, molecular phylogeny and pharmacology. Chapters in this book explore the interrelationship within traditional Chinese medicinal plant groups and between Chinese species and species outside of China. Chapters also discuss the incongruence between chemotaxonomy and molecular phylogeny, concluding with chapters on systems biology and "-omics technologies (genomics, transcriptomics, proteomics, and metabolomics), and how they will play an increasingly important role in future pharmaceutical research. - Reviews best practice and essential developments in medicinal plant chemistry and biology - Discusses the principles and applications of various techniques used to discover medicinal compounds - Explores the analysis and classification of novel plant-based medicinal compounds - Includes case studies on pharmaphylogeny - Compares and integrates traditional knowledge and current perception of worldwide medicinal plants

Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases
Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases

Author: Christophe Wiart

Publisher: Academic Press

Published: 2013-12-16

Total Pages: 415

ISBN-13: 0123983835

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Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases is the second volume in the series, Pharmaceutical Leads from Medicinal Plants. This book includes key pharmacological and chemical evidence to support the selection of promising pre-clinical candidates for the treatment of neurodegenerative diseases. This important addition to the natural product and drug discovery literature contains the history, synonyms, medicinal uses, phytopharmacology, pre-clinical potential, and rationale for each plant selected. By providing critical evaluation of pharmacological data, mechanisms of action, and structural requirements for the development of future neuroprotective agents, this comprehensive reference is a beneficial resource for industry and academic scientists whose research focuses on neurodegenerative drug discovery and development. - Incorporates compelling biological activity data and preclinical structure-activity relationships to help you choose promising lead molecules for further research - Includes primary source references to the most recent natural product discoveries in the field of neuroprotection in order to promote new drug discovery in this area - Contains detailed discussions of important neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease - Each plant section includes a critical evaluation of pharmacological, chemical, and toxicological evidence to support the use of the compound in drug discovery research in neurodegeneration

Phytomedicine
Phytomedicine

Author: Rouf Ahmad Bhat

Publisher: Academic Press

Published: 2021-02-20

Total Pages: 776

ISBN-13: 0128241101

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Phytomedicine: A Treasure of Pharmacologically Active Products from Plants aims to present updated knowledge of plant-based medicines in terms of their research and development, production, and utilization, from the viewpoint of sustainability and by using the latest technologies. The book explores different phytometabolites on a mass scale, coupled with the efficacy, performance and applicability on target organisms to treat curable and fatal diseases. Readers will find a coherent package of phytotherapeutic information regarding inclusive assortment of research based, scientific amplitude of metabolites from the plant world encompassing various action plans. Information is presented sequentially regarding phytochemistry, biological activity and the serviceable aspects of bioactive compounds. The book also addresses various advancements and achievements of novel drugs from plants using molecular and enzymatic activities, and various technological tools in an ecofriendly fashion. - Discusses phytotherapeutic properties for a wide range of medical conditions, including anti-pyretic, anti-infective, anti-malarial, Anti-AIDS, anti-diabetic, anti-cancerous, immune-modulatory applications - Includes a discussion of synergistic effects of formulations and antagonistic drug interactions - Addresses advancements and achievements of novel plant-based drugs using molecular, enzymatic activities and various technological tools in an eco-friendly fashion