"This cutting-edge volume provides a detailed look at the two main aspects of systems biology: the design of sophisticated experimental methods and the development of complex models to analyze the data. Focusing on methods that are being used to solve current problems in biomedical science and engineering, this comprehensive, richly illustrated resource shows you how to: design of state-of-the art methods for analyzing biological systems Implement experimental approaches for investigating cellular behavior in health and disease; use algorithms and modeling techniques for quantitatively describing biomedical problems; and integrate experimental and computational approaches for a more complete view of biological systems." --Book Jacket.
This second volume of eight from the IMAC - XXXII Conference, brings together contributions to this important area of research and engineering. The collection presents early findings and case studies on fundamental and applied aspects of Structural Dynamics, including papers on: Linear Systems Substructure Modelling Adaptive Structures Experimental Techniques Analytical Methods Damage Detection Damping of Materials & Members Modal Parameter Identification Modal Testing Methods System Identification Active Control Modal Parameter Estimation Processing Modal Data
Dynamical systems are a principal tool in the modeling, prediction, and control of a wide range of complex phenomena. As the need for improved accuracy leads to larger and more complex dynamical systems, direct simulation often becomes the only available strategy for accurate prediction or control, inevitably creating a considerable burden on computational resources. This is the main context where one considers model reduction, seeking to replace large systems of coupled differential and algebraic equations that constitute high fidelity system models with substantially fewer equations that are crafted to control the loss of fidelity that order reduction may induce in the system response. Interpolatory methods are among the most widely used model reduction techniques, and Interpolatory Methods for Model Reduction is the first comprehensive analysis of this approach available in a single, extensive resource. It introduces state-of-the-art methods reflecting significant developments over the past two decades, covering both classical projection frameworks for model reduction and data-driven, nonintrusive frameworks. This textbook is appropriate for a wide audience of engineers and other scientists working in the general areas of large-scale dynamical systems and data-driven modeling of dynamics.
Despite the advent and maturation of high-performance computing, high-fidelity physics-based numerical simulations remain computationally intensive in many fields. As a result, such simulations are often impractical for time-critical applications such as fast-turnaround design, control, and uncertainty quantification. The objective of this thesis is to enable rapid, accurate analysis of high-fidelity nonlinear models to enable their use in time-critical settings. Model reduction presents a promising approach for realizing this goal. This class of methods generates low-dimensional models that preserves key features of the high-fidelity model. Such methods have been shown to generate fast, accurate solutions when applied to specialized problems such as linear time-invariant systems. However, model reduction techniques for highly nonlinear systems has been limited primarily to approaches based on the heuristic proper orthogonal decomposition (POD)--Galerkin approach. These methods often generate inaccurate responses because 1) POD--Galerkin does not generally minimize any measure of the system error, and 2) the POD basis is not constructed to minimize errors in the system's outputs of interest. Furthermore, simulation times for these models usually remain large, as reducing the dimension of a nonlinear system does not necessarily reduce its computational complexity. This thesis presents two model reduction techniques that addresses these shortcomings of the POD--Galerkin method. The first method is a `compact POD' approach for computing the small-dimensional trial basis; this approach is applicable to parameterized static systems. The compact POD basis is constructed using a goal-oriented framework that allows sensitivity derivatives to be employed as snapshots. The second method is a Gauss--Newton with approximated tensors (GNAT) method applicable to nonlinear systems. Similar to other POD-based approaches, the GNAT method first executes high-fidelity simulations during a costly `offline' stage; it computes a POD subspace that optimally represents the state as observed during these simulations. To compute fast, accurate `online' solutions, the method introduces two approximations that satisfy optimality and consistency conditions. First, the method decreases the system dimension by searching for the solutions in the low-dimensional POD subspace. As opposed to performing a Galerkin projection, the method handles the resulting overdetermined system of equations arising at each time step by formulating a least-squares problem; this ensures that a measure of the system error (i.e. the residual) is minimized. Second, the method decreases the model's computational complexity by approximating the residual and Jacobian using the `gappy POD' technique; this requires computing only a few rows of the approximated quantities. For computational mechanics problems, the GNAT method leads to the concept of a sample mesh: the subset of the mesh needed to compute the selected rows of the residual and Jacobian. Because the reduced-order model uses only the sample mesh for computations, the online stage requires minimal computational resources.
