PAKs, RAC/CDC42 (p21)-activated Kinases
PAKs, RAC/CDC42 (p21)-activated Kinases

Author: Hiroshi Maruta

Publisher: Newnes

Published: 2013-01-23

Total Pages: 178

ISBN-13: 0124072100

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This book covers a variety of cutting-edge basic and clinical PAK research ranging from laboratory benches to hospital beds. The goal of this book is to inspire not only biomedical research scientists and university students, but also a variety of patients who suffer from PAK-dependent diseases and clinical doctors who try to cure or delay these PAK-dependent diseases.This book consists of 9 chapters which deal with different aspects of this kinase. These chapters are written by more than two dozen world-leading PAK experts. Each of these will provide updated biomedical information as well as future insight to a wide range of readers who are interested in this unique kinase and both its pathological and physiological roles as well as its functional evolution from its ancestral origins. - This publication will be the very first book ever published solely focused on PAK family kinases - Each chapter deals with the latest progress in PAK research written by a leading PAK expert with his or her own ideas and insight - Each chapter of this book has been written in such a way that clinical doctors who seek the effective cure of these formidable diseases, in addition to research scientists and biomedical students will value this book - This book describes in detail a number of PAK blockers which would be potentially useful for the therapy of these PAK-dependent diseases, and some of them are indeed available on the market inexpensively, without any side effect

Cytoskeleton and Small G Proteins
Cytoskeleton and Small G Proteins

Author: Philippe Jeanteur

Publisher: Springer Science & Business Media

Published: 1999-01-21

Total Pages: 254

ISBN-13: 9783540648086

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The internal structure of a cell can be affected by signals in the form of small molecules outside the cell. These changes can then alter the shape or adhesiveness of the cell. This volume centers particularly on one family of cellular proteins which transmit these signals, the Rho Ras-like GTPases, and examines their role in normal cellular processes and development. Also discussed are their roles in cancer formation and microbial pathogenesis.

Physiologic and Pathologic Angiogenesis
Physiologic and Pathologic Angiogenesis

Author: Dan Simionescu

Publisher: BoD – Books on Demand

Published: 2017-04-05

Total Pages: 466

ISBN-13: 9535130234

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The purpose of this book is to highlight novel advances in the field and to incentivize scientists from a variety of fields to pursue angiogenesis as a research avenue. Blood vessel formation and maturation to capillaries, arteries, or veins is a fascinating area which can appeal to multiple scientists, students, and professors alike. Angiogenesis is relevant to medicine, engineering, pharmacology, and pathology and to the many patients suffering from blood vessel diseases and cancer, among others. We are hoping that this book will become a source of inspiration and novel ideas for all.

Conquering RAS
Conquering RAS

Author: Asfar Azmi

Publisher: Academic Press

Published: 2016-08-11

Total Pages: 296

ISBN-13: 0128035412

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Conquering RAS: From Biology to Cancer Therapy provides introductory knowledge on how modern RAS biology is taking shape in light of newer technological development. Each chapter is written in a manner that emphasizes simplicity and readability for both new investigators and established researchers. While RAS biology has been intensively studied for more than three decades, we are yet to see any effective therapeutics that could interfere in the signaling cascade regulated by this master oncogene. The book covers topics ranging from basic RAS biology, to translational biology and drug discovery applications. These topics will be appealing to basic researchers working in labs who seek deeper understanding of the modern concepts in RAS research. On the other side, the oncologist at the patient's bedside will find the book useful as they routinely face the daunting task of treating patients that predominantly have a disease driven by oncogenic KRAS. - Brings together wide ranging topics in RAS basic and translational biology for the scientific and clinical communities - Showcases recent advancements in RAS research under one comprehensive volume - Includes video clips, color illustrations, and important website links to facilitate a clear understanding of RAS in cancer research

Inhibitors of the Ras Superfamily G-proteins, Part A
Inhibitors of the Ras Superfamily G-proteins, Part A

Author:

Publisher: Academic Press

Published: 2013-09-10

Total Pages: 364

ISBN-13: 9780124167490

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This special volume of The Enzymes is targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This thematic volume discusses inhibitors of the Ras superfamily G-proteins. Contributions from leading authorities Informs and updates on all the latest developments in the field

Culturing Nerve Cells
Culturing Nerve Cells

Author: Gary Banker

Publisher: MIT Press

Published: 1998

Total Pages: 706

ISBN-13: 9780262024389

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A do-it-yourself manual for culturing nerve cells, complete with recipes and protocols.

Cell Surface GRP78, a New Paradigm in Signal Transduction Biology
Cell Surface GRP78, a New Paradigm in Signal Transduction Biology

Author: Salvatore V. Pizzo

Publisher: Academic Press

Published: 2018-03-20

Total Pages: 146

ISBN-13: 0128123524

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Cell Surface GRP78, a New Paradigm in Signal Transduction Biology presents a new paradigm that has emerged in the past decade with the discovery that various intracellular proteins may acquire new functions as cell surface receptors. Two very prominent examples are ATP synthase and GRP78. While the role of cell surface ATP synthase has been reviewed in various books, this book directs its attention to the story of cell surface GRP78. - Edited by the researcher who identified cell surface expression of the molecular chaperone GRP78 as a major factor in prostate cancer and other malignancies - Presents an in-depth treatment of the biological underpinnings of GRP78 and its connection to disease - Provides four-color illustrations that facilitate the narrative

G Protein Pathways, Part A: Receptors
G Protein Pathways, Part A: Receptors

Author:

Publisher: Academic Press

Published: 2001-10-09

Total Pages: 719

ISBN-13: 0080884229

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G Protein Pathways is the first of three volumes examining the nature of heterotrimeric G proteins. The text takes an integrated approach to studying common experimental questions at many different levels related to G proteins. Methods related to G proteins using molecular modeling, systems biology, protein engineering, protein biochemistry, cell biology, and physiology are all accessible in the same volume.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant todaytruly an essential publication for researchers in all fields of life sciences.

Neutrophil Methods and Protocols
Neutrophil Methods and Protocols

Author: Mark T. Quinn

Publisher: Springer Science & Business Media

Published: 2007-08-02

Total Pages: 1099

ISBN-13: 1588297888

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This book provides a concise set of protocols for assessing basic neutrophil functions, investigating specialized areas in neutrophil research, and completing step-by-step diagnostic assays of common neutrophil disorders. Each of the protocols is written by leading researchers in the field and includes hints for success, as well as guidance for troubleshooting. Scientists and clinicians will find this collection an invaluable aid.

Hyaluronan in Cancer Biology
Hyaluronan in Cancer Biology

Author: Robert Stern

Publisher: Academic Press

Published: 2009-03-07

Total Pages: 467

ISBN-13: 0080921086

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Hyaluronan biology is being recognized as an important regulator of cancer progression. Paradoxically, both hyaluronan (HA) and hyaluronidases, the enzymes that eliminate HA, have also been correlated with cancer progression. Hyaluronan, a long-chain polymer of the extracellular matrix, opens up tissue spaces through which cancer cells move and metastasize. It also confers motility upon cells through interactions of cell-surface HA with the cytoskeleton. Embryonic cells in the process of movement and proliferation use the same strategy. It is an example of how cancer cells have commandeered normal cellular processes for their own survival and spread. There are also parallels between cancer and wound healing, cancer occasionally being defined as a wound that does not heal. The growing body of literature regarding this topic has recently progressed from describing the association of hyaluronan and hyaluronidase expression associated with different cancers, to understanding the mechanisms that drive tumor cell activation, proliferation, drug resistance, etc. No one source, however, discusses hyaluronan synthesis and catabolism, as well as the factors that regulate the balance. This book will offer a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer. - Offers a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer - Chapters are written by the leading international authorities on this subject, from laboratories that focus on the investigation of hyaluronan in cancer initiation, progression, and dissemination - Focuses on understanding the mechanisms that drive tumor cell activation, proliferation, and drug resistance