To improve public confidence in clinical research, a number of public and private groups have called for a publicly accessible, comprehensive, and transparent registry of relevant information on clinical trials for drugs and biologics. The public and various entities within the medical community (health care providers, researchers, medical journal editors, pharmaceutical companies, health insurers, and regulators) have different expectations and perceived needs regarding a public clinical trial registry. The IOM Committee on Clinical Trial Registries hosted a workshop on June 27, 2005, to obtain much-needed input from members of the public, public advocate groups, and the broader community of journal editors, pharmaceutical and biotech leaders, NIH, and the FDA. Participants discussed the data elements that have been at the core of debate and commented on issues of compliance and implementation of a national clinical trial registry. Developing a National Registry of Pharmacologic and Biologic Clinical Trials: Workshop Report inlcudes discussions at the workshop centered on the following five concepts, and are described within this report: 1) Purpose, 2) Which Trials to Include, 3) Delayed Disclosure Mechanism, 4) Reporting Results of Completed Trials, and 5) Compliance.
This textbook introduces and explains basic chiropractic philosophy and history, principles, and applications in practice. In addition to covering chiropractic care techniques, it also discusses anatomy, biomechanics, and physiology, as well as spinal analysis and diagnostic procedures. Key scientific and philosophical issues within the chiropractic community are addressed. Clearly presented material in an easy-to-follow format defines unfamiliar terms, explains and illustrates concepts, and reinforces ideas through review and critical thinking questions. The book's broad scope and discussions of diverse topics make it ideal for students or anyone in the chiropractic community. - Topics and content parallel the test plan outlines from the National Board of Chiropractic Examiners, ensuring that all material is relevant, up-to-date, and accurate. - Well-known chapter contributors - some of the most respected and influential names in the field - give the book a balanced approach, reflecting the diversity within the profession on issues related to the science and philosophy of chiropractic. - Well-referenced discussions include the most up-to-date research. - Key terms and critical thinking/review questions in each chapter familiarize the reader with important concepts and promote a solid understanding of the material.
The purpose of this report is to summarize the literature concerning the relationship of breastfeeding and various infant and maternal health outcomes. Two key questions are addressed: 1. What are the benefits and harms for infants and children in terms of short-term outcomes, such as infectious diseases (including otitis media, diarrhea, and lower respiratory tract infections), sudden infant death syndrome (SIDS) and infant mortality, and longer term outcomes such as cognitive development, childhood cancer (including leukemia), type I and II diabetes, asthma, atopic dermatitis, cardiovascular disease (including hypertension), hyperlipidemia, and obesity, compared among those who mostly breastfeed, mostly formula feed, and mixed feed; and how are these outcomes associated with duration of the type of feeding? Do the harms and benefits differ for any specific subpopulations based on socio-demographic factors? 2. What are the benefits and harms on maternal health short-term outcomes, such as postpartum depression and return to pre-pregnancy weight, and long-term outcomes, such as breast cancer, ovarian cancer, diabetes and osteoporosis, compared among breastfeeding, formula feeding, and mixed feeding, and how are these associated with duration of the type of feeding? Do the harms and benefits differ for any specific subpopulations based on socio-demographic factors?
The Scientific Style and Format Eighth Edition Subcommittee worked to ensure the continued integrity of the CSE style and to provide a progressively up-to-date resource for our valued users, which will be adjusted as needed on the website. This new edition will prove to be an authoritative tool used to help keep the language and writings of the scientific community alive and thriving, whether the research is printed on paper or published online.