Medication-Related Osteonecrosis of the Jaws
Medication-Related Osteonecrosis of the Jaws

Author: Sven Otto

Publisher: Springer

Published: 2014-11-27

Total Pages: 216

ISBN-13: 3662437333

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Osteonecrosis of the jaws is a well-known side-effect of antiresorptive therapy that predominantly occurs in patients suffering from malignant diseases and receiving intravenous administrations of nitrogen-containing bisphosphonates or subcutaneous administrations of denosumab, a monoclonal antibody. Less frequently it may also be observed in patients with osteoporosis who are being treated with these antiresorptive drugs This textbook provides detailed, up-to-date information on all aspects of medication-related osteonecrosis of the jaws, including clinical features, pathogenesis, treatment options, and preventive measures. It also explains safe prevention and treatment strategies for patients receiving antiresorptive drugs who require extractions, implant insertions, and other dento-alveolar surgeries. This book will be of major interest for medical and dental students, dentists, and oral and maxillofacial surgeons as well as osteologists and oncologists.

Antiresorptive Drug-Related Osteonecrosis of the Jaw (ARONJ) - A Guide to Research
Antiresorptive Drug-Related Osteonecrosis of the Jaw (ARONJ) - A Guide to Research

Author: Kenneth E. Fleisher

Publisher: Thieme

Published: 2016-09-16

Total Pages: 125

ISBN-13: 3132412716

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A collaboration between some of the leading international experts in the field, AOCMF proudly presents Antiresorptive Drug-related Osteonecrosis of the Jaw (ARONJ)-a Guide to Research, which unravels the many biologic processes and risk factors associated with this debilitating condition. With its unknown pathophysiology, lack of established management regimens, and because of the millions of patients currently taking antiresorptive agents, this important book on ARONJ has been produced to provide the latest in contemporary evidence and insight. The book's key features include: Detailed analysis of the historical definitions, classifications, and clinical features of ARONJ Review of the risk factors and treatment options currently available, and why the jaw bone is predominantly affected Discussion on the use of large and small animals in modelling. With dozens of clinical images to help illustrate the impact of this condition on real patients, Antiresorptive Drug-related Osteonecrosis of the Jaw (ARONJ)-a Guide to Research is an excellent resource for anyone involved or interested in this important medical field.

Drug-Induced Oral Complications
Drug-Induced Oral Complications

Author: Sarah Cousty

Publisher: Springer Nature

Published: 2021-05-24

Total Pages: 124

ISBN-13: 3030669734

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This book provides detailed information on the prevalence and manifestations of the most important oral complications associated with different drug treatments, focusing especially on recently developed therapies. Among the diverse adverse drug reactions covered are gingival overgrowth, ulcerations, lichenoid reactions, pigmentation, and bullous reactions. The potential direct toxic effects on bone of drugs that prevent bone mass loss, such as bisphosphonates and denosumab, are fully examined, as is the occurrence of spontaneous oral bleeding in patients receiving antithrombotic therapies. Further chapters focus on drug-induced taste disorders and salivary gland disturbances, including xerostomia, swelling, and hypersalivation. The enhanced risk of oral infections when using chemotherapy and biotherapy is addressed, and the closing chapter examines drug-related perioral and facial complications. This book is a collaborative work that brings together clinicians, surgeons, and specialists in drug safety surveillance. It will be of value for all dental and medical practitioners who encounter these complications in their clinical practice.

Oral and Maxillofacial Surgery for the Clinician
Oral and Maxillofacial Surgery for the Clinician

Author: Krishnamurthy Bonanthaya

Publisher: Springer Nature

Published: 2021

Total Pages: 1965

ISBN-13: 9811513465

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This is an open access book with CC BY 4.0 license. This comprehensive open access textbook provides a comprehensive coverage of principles and practice of oral and maxillofacial surgery. With a range of topics starting from routine dentoalveolar surgery to advanced and complex surgical procedures, this volume is a meaningful combination of text and illustrations including clinical photos, radiographs, and videos. It provides guidance on evidence-based practices in context to existing protocols, guidelines and recommendations to help readers deal with most clinical scenarios in their daily surgical work. This multidisciplinary textbook is meant for postgraduate trainees, young practicing oral surgeons and experienced clinicians, as well as those preparing for university and board certification exams. It also aids in decision-making, the implementation of treatment plans and the management of complications that may arise. This book is an initiative of Association of Oral and Maxillofacial Surgeons of India (AOMSI) to its commitment to academic medicine. As part of this commitment, this textbook is in open access to help ensure widest possible dissemination to readers across the world. ; Open access Unique presentation with contents divided into color-coded core competency gradations Covers all aspects of oral and maxillofacial surgery Supplemented with videos of all commonly carried out procedures as operative video Every chapter or topic concludes with "future perspective" and addresses cutting edge advances in each area Every topic has a pull out box that provides the most relevant systematic reviews/ key articles to every topic.

Lasers in Oral and Maxillofacial Surgery
Lasers in Oral and Maxillofacial Surgery

Author: Stefan Stübinger

Publisher: Springer Nature

Published: 2020-03-25

Total Pages: 263

ISBN-13: 3030296040

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This book provides surgeons with important insights into laser technologies as well as a sound understanding of their current and potential applications within oral and maxillofacial surgery and related disciplines. The opening chapters focus on the relevant physical background, the technology of the typically used lasers, laser–tissue interactions, and the treatment systems. Detailed information is then provided on the various established applications of laser treatments, including in relation to skin and mucosa and the dental hard tissues and bone. Special applications are also described, for example with respect to periodontal surgery, peri-implantitis therapy, photodynamic treatment, holography and additive manufacturing. The book closes by examining technologies that will soon be available for application in hospitals, topics which are currently the subject of research, and laser safety. Beyond surgeons, the book will be of value for engineers and scientists working in the field of medical engineering using lasers.

Bisphosphonates and Osteonecrosis of the Jaw: A Multidisciplinary Approach
Bisphosphonates and Osteonecrosis of the Jaw: A Multidisciplinary Approach

Author: Francesco Saverio De Ponte

Publisher: Springer Science & Business Media

Published: 2011-11-25

Total Pages: 186

ISBN-13: 8847020832

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During the early 19th century, it was discovered that adding yellow (now called white) phosphorous to matchstick heads made it easier to ignite matches. The phosphorous vapors were breathed in by workers and combined with other chemicals in the body to produce a potent nitrogen-containing bisphosphonate. Today's oral nitrogen-containing bisphosphonates and intravenous nitrogen-containing bisphosphonates circulate around the body the same way as the phosphorous vapors, and are absorbed into bone and ingested by osteoclasts. When this unique binding process of bisphosphonates to bone occurs, osteoclasts are poisoned, and this reduces or eliminates bone turnover. Alveolar bone in the mandible and maxilla turns over more rapidly than in long bones, so the jaws are a better target for bisphosphonate toxicity. It wasn't until 2003 that today's intravenous and oral nitrogen-containing bisphosphonate medications were implicated as major risk factors in the development of exposed necrotic bone of the jaws. Most of the researchers who reported cases of bisphosphonate-induced osteonecrosis of the jaw found that these patients were treated with zoledronate, pamidronate, or a combination of these drugs, which are commonly used for treating breast cancer or myeloma. In about 5% of cases, subjects with BIONJ were being treated for osteoporosis. Precipitating events that contribute to BIONJ are tooth extractions (about 50% of cases), mandibular exostoses, periodontal disease, and local trauma from ill-fitting dentures. It is not known if the placement of dental implants is a precipitating factor. The book aims to meet the need of medical practitioners working in all fields that use bisphosphonates, and to present the conservative and surgical treatment methods currently in use. There will also be detailed information on the literature relating to dental implants in patients treated with bisphosphonates.

Osteomyelitis of the Jaws
Osteomyelitis of the Jaws

Author: Marc Baltensperger

Publisher: Springer Science & Business Media

Published: 2008-11-07

Total Pages: 320

ISBN-13: 3540287663

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“Osteomyelitis of the Jaws” is the first textbook of its kind covering exclusively all aspects of this challenging disease. A clear classification of osteomyelitis of the jaws is provided. Clinical presentation and diagnosis are meticulously described and illustrated. Radiological imaging from conventional radiographs to CT, MRI and PET diagnosis are outlined for all types of osteomyelitis of the jaws. Pathology and Pathophysiology of this disease are described in a clear way. All therapeutic modalities from surgery to antibiotic and hyperbaric oxygen therapy are comprehensively outlined and discussed. Each type of Osteomyelitis of the jaws are additionally described and illustrated in case reports giving this book a very practical approach to the subject.

Complications in Cranio-Maxillofacial and Oral Surgery
Complications in Cranio-Maxillofacial and Oral Surgery

Author: Robert Gassner

Publisher: Springer Nature

Published: 2020-07-31

Total Pages: 307

ISBN-13: 3030401502

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This superbly illustrated book equips readers with a detailed, up-to-date understanding of the surgical and nonsurgical complications that may arise during cranio-maxillofacial and oral surgery for a range of conditions, including malformations, infections, trauma, and tumors. It will aid both in the prevention of complications and in their effective management, across all age groups. Among the diverse surgical settings considered are cleft lip and palate, odontogenic and non-odontogenic infections, temporomandibular joint disorders, cranio-maxillofacial trauma, oral cancer, and skull base tumors. Potential complications during and after reconstructive procedures, including donor site morbidity, are considered. The book is designed to heighten awareness and to fill gaps in knowledge by providing novel insights. It will be of value for all clinicians, residents, and medical and dental students who are interested in oral, maxillofacial, craniofacial, plastic, reconstructive, and head and neck surgery.

The Duration and Safety of Osteoporosis Treatment
The Duration and Safety of Osteoporosis Treatment

Author: Stuart Silverman

Publisher: Springer

Published: 2015-12-29

Total Pages: 349

ISBN-13: 3319236393

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Providing a comprehensive review of short-and long-term adverse events of both antiresorptive and anabolic drugs, this practical guide updates the clinician on the pathophysiology of osteoporosis and the principles behind our present and future pharmaceuticals. Leading practitioners in the field examine all current literature and data regarding the duration and safety of these therapies, with recommendations for clinicians on decision-making and best practices for osteoporosis patients. An overview of the pathophysiology and epidemiology of osteoporosis and discussion of both anabolic and antiresorptive drugs is followed by fracture risk assessment and an examination of treatment failures. Next, a number of chapters are dedicated to the diagnosis, presentation and management of atypical femur fractures and osteonecrosis of the jaw (ONJ), each of which are significant patient concerns when using these osteoporosis treatments. The introduction and utilization of drug holidays is also discussed, as well as the long-term outlook for management of osteoporotic patients. Written and edited by experts in the field, The Duration and Safety of Osteoporosis Treatment is a balanced resource for researchers, practitioners and policy-makers alike for clinical decision-making and patient care.