Measurement Technologies for up- and Downstream Bioprocessing

Measurement Technologies for up- and Downstream Bioprocessing

Author: Carl-Fredrik Mandenius

Publisher: MDPI

Published: 2021-09-01

Total Pages: 160

ISBN-13: 3036511504

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This book is devoted to new developments in measurement technologies for upstream and downstream bioprocessing. The recent advances in biotechnology and bioprocessing have generated a number of new biological products that require more qualified analytical technologies for diverse process analytical needs. These includes especially fast and sensitive measurement technology that, early in the process train, can inform on critical process parameters related to process economy and product quality and that can facilitate ambitions of designing efficient integrated end-to-end bioprocesses. This book covers these topics as well as analytical monitoring methods based either on real-time or in-line sensor technology, on simple and compact bioanalytical devices, or on the use of advanced data prediction methods.


Biopharmaceutical Processing

Biopharmaceutical Processing

Author: Gunter Jagschies

Publisher: Elsevier

Published: 2018-01-18

Total Pages: 1310

ISBN-13: 0128125527

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Biopharmaceutical Processing: Development, Design, and Implementation of Manufacturing Processes covers bioprocessing from cell line development to bulk drug substances. The methods and strategies described are essential learning for every scientist, engineer or manager in the biopharmaceutical and vaccines industry. The integrity of the bioprocess ultimately determines the quality of the product in the biotherapeutics arena, and this book covers every stage including all technologies related to downstream purification and upstream processing fields. Economic considerations are included throughout, with recommendations for lowering costs and improving efficiencies. Designed for quick reference and easy accessibility of facts, calculations and guidelines, this book is an essential tool for industrial scientists and managers in the biopharmaceutical industry. - Offers a comprehensive, go-to reference for daily work decisions - Covers both upstream and downstream processes - Includes case studies that emphasize financial outcomes - Presents summaries, decision grids, graphs and overviews for quick reference


Encyclopedia of Agricultural, Food, and Biological Engineering

Encyclopedia of Agricultural, Food, and Biological Engineering

Author: Dennis R. Heldman

Publisher: CRC Press

Published: 2010-10-21

Total Pages: 2001

ISBN-13: 1498711073

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Examining the role of engineering in delivery of quality consumer products, this expansive resource covers the development and design of procedures, equipment, and systems utilized in the production and conversion of raw materials into food and nonfood consumer goods. With nearly 2000 photographs, figures, tables, and equations including 128 color figures the book emphasizes and illustrates the various engineering processes associated with the production of materials with agricultural origin. With contributions from more than 350 experts and featuring more than 200 entries and 3600 references, this is the largest and most comprehensive guide on raw production technology.


Continuous Biomanufacturing

Continuous Biomanufacturing

Author: Ganapathy Subramanian

Publisher: John Wiley & Sons

Published: 2017-12-26

Total Pages: 628

ISBN-13: 3527340637

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This is the most comprehensive treatise of this topic available, providing invaluable information on the technological and economic benefits to be gained from implementing continuous processes in the biopharmaceutical industry. Top experts from industry and academia cover the latest technical developments in the field, describing the use of single-use technologies alongside perfusion production platforms and downstream operations. Special emphasis is given to process control and monitoring, including such topics as 'quality by design' and automation. The book is supplemented by case studies that highlight the enormous potential of continuous manufacturing for biopharmaceutical production facilities.


Bioprocess Technology

Bioprocess Technology

Author: Anton Moser

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 480

ISBN-13: 1461387485

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This book is based on a 1981 German language edition published by Springer Verlag, Vienna, under the title Bioprozesstechnik. Philip Manor has done the translation, for which I am deeply grateful. This book differs from the German edition in many ways besides language. It is substantially enlargened and updated, and examples of computer simula tions have been added together with other appendices to make the work both more comprehensive and more practical. This book is the result of over 15 years of experience in teaching and research. It stems from lectures that I began in 1970 at the Technical University of Graz, Austria, and continued at the University of Western Ontario in London, Canada, 1980; at the Free University of Brussels, 1981; at Chalmers Technical University in G6teborg, Sweden; at the Academy of Sciences in lena, East Germany; at the "Haus der Technik" in Essen, West Germany, 1982; at the Academy of Science in Sofia, Bulgaria; and at the Technical University of Delft, Netherlands, 1986. The main goals of this book are, first, to bridge the gap that always exists between basic principles and applied engineering practice, second, to enhance the integration between biological and physical phenomena, and, third, to contribute to the internal development of the field of biotechnology by describing the process-oriented field of bioprocess technology.


UPSTREAM AND DOWNSTREAM PROCESSING OF BIOPRODUCTS

UPSTREAM AND DOWNSTREAM PROCESSING OF BIOPRODUCTS

Author: R. Puvanakrishnan

Publisher: MJP Publisher

Published: 2019-06-20

Total Pages: 242

ISBN-13:

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Microorganisms have been exploited for many centuries for the production of fermented foods and beverages and for bread-making. The production of alcoholic beverages using microbes was the first major industrialized process. The technology developed for large-scale brewing was adapted for other anaerobic processes such as acetone and butanol in the early 1900s. With the discovery of penicillins, rapid developments were made in the technology of submerged culture fermentation of aerobic microorganisms under controlled conditions. The advancements in microbiology and process biochemistry improved our ability to harness the potential of microorganisms through improved bioprocessing methods to manufacture new products with economic viability. Microbial derived bioproducts have been gaining importance in the food, pharmaceutical, textile, leather, cosmetic and chemical industries, and most important among them are therapeutic proteins and peptides, enzymes, antigens, vaccines, antibiotics, drugs, etc.Not all microbial production processes involve culture of the organism in liquid medium. Instead, the organism can be grown on the surface of a solid substrate. Solid substrate (or solid state) fermentation (SSF) is an established traditional technology in many countries, producing edible mushrooms, fungal- fermented foods and soy sauce. Before the development of processes in liquid culture, citric acid and some microbial enzymes were produced by SSF. Carbon composting is also a form of SSF.


Viral Vectors in Veterinary Vaccine Development

Viral Vectors in Veterinary Vaccine Development

Author: Thiru Vanniasinkam

Publisher: Springer Nature

Published: 2020-11-30

Total Pages: 232

ISBN-13: 3030519279

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This highly accessible textbook introduces readers to the development of viral vectors and discusses their application in veterinary vaccinology. It offers comprehensive information on the latest advances in this emerging research field, together with a broad overview of the history of veterinary vaccines and viral vectors. The book also addresses issues concerning funding, translational research and ethics that will impact the future development, manufacture and global use of viral vector-based veterinary vaccines. The book addresses the needs of graduate students and researchers in the fields of Veterinary Medicine, Virology and Immunology. ​