Mathematical Modeling of Biosensors
Mathematical Modeling of Biosensors

Author: Romas Baronas

Publisher: Springer Science & Business Media

Published: 2009-11-12

Total Pages: 342

ISBN-13: 9048132436

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Biosensors are analytical devices in which speci?c recognition of the chemical substances is performed by biological material. The biological material that serves as recognition element is used in combination with a transducer. The transducer transforms concentration of substrate or product to electrical signal that is amp- ?ed and further processed. The biosensors may utilize enzymes, antibodies, nucleic acids, organelles, plant and animal tissue, whole organism or organs. Biosensors containing biological catalysts (enzymes) are called catalytical biosensors. These type of biosensors are the most abundant, and they found the largest application in medicine, ecology, and environmental monitoring. The action of catalytical biosensors is associated with substrate diffusion into biocatalytical membrane and it conversion to a product. The modeling of bios- sors involves solving the diffusion equations for substrate and product with a term containing a rate of biocatalytical transformation of substrate. The complications of modeling arise due to solving of partially differential equations with non-linear biocatalytical term and with complex boundary and initial conditions. The book starts with the modeling biosensors by analytical solution of partial differential equations. Historically this method was used to describe fundamental features of biosensors action though it is limited by substrate concentration, and is applicable for simple biocatalytical processes. Using this method the action of biosensors was analyzed at critical concentrations of substrate and enzyme activity.

Mathematical Modeling of Biosensors
Mathematical Modeling of Biosensors

Author: Romas Baronas

Publisher: Springer Nature

Published: 2021-02-15

Total Pages: 456

ISBN-13: 3030655059

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This newly designed and enlarged edition offers an up-to-date presentation of biosensor development and modeling from both a chemical and a mathematical point of view. An entire new chapter in particular is dedicated to optimal design of biosensors. Two more new chapters discuss biosensors which utilize microbial cells and are based on carbon nanotubes respectively. All the other chapters have been revised and updated. The book contains unique modeling methods for amperometric, potentiometric and optical biosensors based mainly on biocatalysts . It examines processes that occur in the sensors' layers and at their interface, and it provides analytical and numerical methods to solve equations of conjugated enzymatic (chemical) and diffusion processes. The action of single enzyme as well as polyenzyme biosensors and biosensors based on chemically modified electrodes is studied. The modeling of biosensors that contain perforated membranes and multipart mass transport profiles is critically investigated. Furthermore, it is fully described how signals can be biochemically amplified, how cascades of enzymatic substrate conversion are triggered, and how signals are processed via a chemometric approach and artificial neuronal networks. The results of digital modeling are compared with both proximal analytical solutions and experimental data.

Chemical Sensors and Biosensors
Chemical Sensors and Biosensors

Author: Florinel-Gabriel Banica

Publisher: John Wiley & Sons

Published: 2012-08-15

Total Pages: 795

ISBN-13: 1118354230

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Key features include: Self-assessment questions and exercises Chapters start with essential principles, then go on to address more advanced topics More than 1300 references to direct the reader to key literature and further reading Highly illustrated with 450 figures, including chemical structures and reactions, functioning principles, constructive details and response characteristics Chemical sensors are self-contained analytical devices that provide real-time information on chemical composition. A chemical sensor integrates two distinct functions: recognition and transduction. Such devices are widely used for a variety of applications, including clinical analysis, environment monitoring and monitoring of industrial processes. This text provides an up-to-date survey of chemical sensor science and technology, with a good balance between classical aspects and contemporary trends. Topics covered include: Structure and properties of recognition materials and reagents, including synthetic, biological and biomimetic materials, microorganisms and whole-cells Physicochemical basis of various transduction methods (electrical, thermal, electrochemical, optical, mechanical and acoustic wave-based) Auxiliary materials used e.g. synthetic and natural polymers, inorganic materials, semiconductors, carbon and metallic materials properties and applications of advanced materials (particularly nanomaterials) in the production of chemical sensors and biosensors Advanced manufacturing methods Sensors obtained by combining particular transduction and recognition methods Mathematical modeling of chemical sensor processes Suitable as a textbook for graduate and final year undergraduate students, and also for researchers in chemistry, biology, physics, physiology, pharmacology and electronic engineering, this bookis valuable to anyone interested in the field of chemical sensors and biosensors.

Microfluidics
Microfluidics

Author: Bastian E. Rapp

Publisher: Elsevier

Published: 2022-10-07

Total Pages: 850

ISBN-13: 0128240237

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Microfluidics: Modeling, Mechanics and Mathematics, Second Edition provides a practical, lab-based approach to nano- and microfluidics, including a wealth of practical techniques, protocols and experiments ready to be put into practice in both research and industrial settings. This practical approach is ideally suited to researchers and R&D staff in industry. Additionally, the interdisciplinary approach to the science of nano- and microfluidics enables readers from a range of different academic disciplines to broaden their understanding. Alongside traditional fluid/transport topics, the book contains a wealth of coverage of materials and manufacturing techniques, chemical modification/surface functionalization, biochemical analysis, and the biosensors involved. This fully updated new edition also includes new sections on viscous flows and centrifugal microfluidics, expanding the types of platforms covered to include centrifugal, capillary and electro kinetic platforms. - Provides a practical guide to the successful design and implementation of nano- and microfluidic processes (e.g., biosensing) and equipment (e.g., biosensors, such as diabetes blood glucose sensors) - Provides techniques, experiments and protocols that are ready to be put to use in the lab, or in an academic or industry setting - Presents a collection of 3D-CAD and image files on a companion website

Chemical Sensors and Biosensors
Chemical Sensors and Biosensors

Author: Brian R. Eggins

Publisher: John Wiley & Sons

Published: 2008-04-30

Total Pages: 298

ISBN-13: 0470511311

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Covering the huge developments in sensor technology and electronic sensing devices that have occurred in the last 10 years, this book uses an open learning format to encourage reader understanding of the subject. An invaluable distance learning book Applications orientated providing invaluable aid for anyone wishing to use chemical and biosensors Key features and subjects covered include the following: Sensors based on both electrochemical and photometric transducers Mass-sensitive sensors Thermal-sensitive sensors Performance factors for sensors Examples of applications Detailed case studies of five selected sensors 30 discussion questions with worked examples and 80 self-assessment questions 140 explanatory diagrams An extensive bibliography

Multiscale Modelling in Biomedical Engineering
Multiscale Modelling in Biomedical Engineering

Author: Dimitrios I. Fotiadis

Publisher: John Wiley & Sons

Published: 2023-05-05

Total Pages: 404

ISBN-13: 1119517354

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Multiscale Modelling in Biomedical Engineering Discover how multiscale modeling can enhance patient treatment and outcomes In Multiscale Modelling in Biomedical Engineering, an accomplished team of biomedical professionals delivers a robust treatment of the foundation and background of a general computational methodology for multi-scale modeling. The authors demonstrate how this methodology can be applied to various fields of biomedicine, with a particular focus on orthopedics and cardiovascular medicine. The book begins with a description of the relationship between multiscale modeling and systems biology before moving on to proceed systematically upwards in hierarchical levels from the molecular to the cellular, tissue, and organ level. It then examines multiscale modeling applications in specific functional areas, like mechanotransduction, musculoskeletal, and cardiovascular systems. Multiscale Modelling in Biomedical Engineering offers readers experiments and exercises to illustrate and implement the concepts contained within. Readers will also benefit from the inclusion of: A thorough introduction to systems biology and multi-scale modeling, including a survey of various multi-scale methods and approaches and analyses of their application in systems biology Comprehensive explorations of biomedical imaging and nanoscale modeling at the molecular, cell, tissue, and organ levels Practical discussions of the mechanotransduction perspective, including recent progress and likely future challenges In-depth examinations of risk prediction in patients using big data analytics and data mining Perfect for undergraduate and graduate students of bioengineering, biomechanics, biomedical engineering, and medicine, Multiscale Modelling in Biomedical Engineering will also earn a place in the libraries of industry professional and researchers seeking a one-stop reference to the basic engineering principles of biological systems.

New Perspectives in Biosensors Technology and Applications
New Perspectives in Biosensors Technology and Applications

Author: Pier Andrea Serra

Publisher: BoD – Books on Demand

Published: 2011-07-27

Total Pages: 462

ISBN-13: 9533074485

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A biosensor is a detecting device that combines a transducer with a biologically sensitive and selective component. Biosensors can measure compounds present in the environment, chemical processes, food and human body at low cost if compared with traditional analytical techniques. This book covers a wide range of aspects and issues related to biosensor technology, bringing together researchers from 12 different countries. The book consists of 20 chapters written by 69 authors and divided in three sections: Biosensors Technology and Materials, Biosensors for Health and Biosensors for Environment and Biosecurity.

Advanced Chemical Kinetics
Advanced Chemical Kinetics

Author: Muhammad Akhyar Farrukh

Publisher: BoD – Books on Demand

Published: 2018-02-21

Total Pages: 226

ISBN-13: 9535138154

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The book on Advanced Chemical Kinetics gives insight into different aspects of chemical reactions both at the bulk and nanoscale level and covers topics from basic to high class. This book has been divided into three sections: (i) "Kinetics Modeling and Mechanism," (ii) "Kinetics of Nanomaterials," and (iii) "Kinetics Techniques." The first section consists of six chapters with a variety of topics like activation energy and complexity of chemical reactions; the measurement of reaction routes; mathematical modeling analysis and simulation of enzyme kinetics; mechanisms of homogeneous charge compression ignition combustion for the fuels; photophysical processes and photochemical changes; the mechanism of hydroxyl radical, hydrate electron, and hydrogen atom; and acceptorless alcohol dehydrogenation. The understanding of the kinetics of nanomaterials, to bridge the knowledge gap, is presented in the second section. The third section highlights an overview of experimental techniques used to study the mechanism of reactions.

Proceedings of the international conference "“NUMERICAL COMPUTATIONS: THEORY AND ALGORITHMS”
Proceedings of the international conference

Author: Yaroslav D. Sergeyev

Publisher: Luigi Pellegrini Editore

Published: 2013-06-27

Total Pages: 153

ISBN-13: 8868220334

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This book contains Proceedings of the International Conference and Summer School NUMTA-2013 “Numerical Computations: Theory and Algorithms”. The Conference is organized jointly by the University of Calabria, Italy, and by the N.I. Lobachevsky State University of Nizhni Novgorod, Russia in cooperation with the Society for Industrial and Applied Mathematics (SIAM), USA. The goal of the Conference is to create a multidisciplinary round table for an open discussion on numerical modeling nature by using traditional and emerging computational paradigms. The Conference discusses all aspects of numerical computations and modeling from foundations and philosophy to advanced numerical techniques. New technological challenges and fundamental ideas from theoretical computer science, linguistic, logic, set theory, and philosophy meet requirements and new fresh applications from physics, chemistry, biology, and economy.