The IGF System
The IGF System

Author: Ron G. Rosenfeld

Publisher: Springer Science & Business Media

Published: 1999-06-01

Total Pages: 883

ISBN-13: 1592597122

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It has been over 40 years since the original report by Salmon and Daughaday demon strating that the ability of GH to stimulate sulfation of cartilage was mediated by a "sulfation factor. " In the ensuing decades, it has become apparent that this "sulfation factor activity" encompasses a complex system ofligands (IGFs), receptors, and carrier proteins that are, in tum, responsible for a wide array of cellular actions. The IGF system has been demonstrated to be critically involved in both intrauterine and postnatal growth, and to have important implications in cancer biology as well, owing to the ability of the IGFs to function in endocrine, paracrine, and autocrine modes and given the wide distri bution of IGFs in virtually every organ system. The contributions to The /GF System reflect the wide span of interest in the IGF system and its implications for normal and abnormal growth and metabolism. The chapters have been divided into four broad sections: I. Molecular biology of the IGF system; II. Bio logical actions of the IGFs; III. IGF physiology; and IV. Clinical aspects of the IGFs. We have made every effort to highlight the major contemporary themes in IGF biology, but as is inevitable in such a fast-moving field, perspectives will continue to change as new information is accumulated.

Insulin and IGFs
Insulin and IGFs

Author:

Publisher: Academic Press

Published: 2009-03-10

Total Pages: 766

ISBN-13: 0080922155

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First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.This volume focuses on insulin and IGFs. - Longest running series published by Academic Press - Contributions by leading international authorities

IGFs:Local Repair and Survival Factors Throughout Life Span
IGFs:Local Repair and Survival Factors Throughout Life Span

Author: David Clemmons

Publisher: Springer Science & Business Media

Published: 2009-12-01

Total Pages: 166

ISBN-13: 364204302X

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Insulin-like growth factors (IGFs), their binding proteins and their receptors play important roles in regulating growth, metabolism, proliferation and survival for many cells and tissues throughout lifespan in humans and other species. Circulating IGF1 is known to be an endocrine regulator, with metabolic effects related to, and partly convergent with, insulin signalling. IGF1 also mediates many of the growth promoting effects of GH, and there is an ongoing debate as to the relative contributions of endocrine-, vs locally-derived IGF1 for systemic growth. More recently however, it has become clear that IGFs may be key local growth and cellular survival factors for many different tissues, active from early in embryonic development, essential for normal maturation and growth during foetal life. IGFs continue to play important roles throughout adult life in many diverse processes such as tissue repair, cellular proliferation, tissue remodelling and metabolic regulation. IGF systems are tightly regulated; orderly control of cellular repair and metabolism is central to healthy ageing, whilst uncontrolled proliferation can lead to cancer.

Insulin-Like Growth Factors
Insulin-Like Growth Factors

Author: Douglas Yee

Publisher: IOS Press

Published: 2004

Total Pages: 134

ISBN-13: 9781586034092

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Over the past five years there has been an explosion of "targeted therapies" for cancer treatment. In most cases, these therapies have been based on pre-clinical data showing that specific molecules play an important role in regulating the malignant phenotype. In breast cancer, there is compelling rationale that such targeted strategies should be successful. Targeting of estrogen receptor ? (ER?) has proven to be a successful way to reduce breast cancer risk, decrease the risk of death and recurrence in an adjuvant setting, and remains the first choice of treatment for advanced disease. With this success, it is hoped that other molecular pathways could also be successfully exploited. This publication reviews the role of the insulin-like growth factors (IGFs) in breast cancer. Over 100 years ago George Beatson made an intuitive leap connecting breast cancer therapy with ovarian function He removed the ovaries from a premenopausal woman with breast cancer; he reasoned that ovarian function regulated normal mammary gland function, therefore the ovaries may influence the malignant phenotype. Other discussion included cover the function of IGF action in the normal mammary gland using mouse model systems where expression and function can be manipulated and the patterns of expression of the IGFs, their binding proteins, and their receptors in the normal gland.

Hormonal Regulation of Farm Animal Growth
Hormonal Regulation of Farm Animal Growth

Author: K. L. Hossner

Publisher: CABI

Published: 2005

Total Pages: 242

ISBN-13: 9781845930905

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This book describes the cellular and molecular mechanisms that control farm animal growth, includingdevelopment and body composition. The emphasis is on circulating hormones, local growth factors andgene transcription factors which regulate growth and differentiation of skeletal muscle, bone andadipose tissue. Overall, this book will be an important resource for students that have a limitedbackground in cell, molecular and developmental biology and the effect of endocrine and growthfactors on the growth process.

Growth of Farm Animals, 3rd Edition
Growth of Farm Animals, 3rd Edition

Author: Tony Leonard John Lawrence

Publisher: CABI

Published: 2012

Total Pages: 368

ISBN-13: 1845935586

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An understanding of the processes that change the shape and composition of farm animals is fundamental to all aspects of production. Updated to include new chapters on avian growth and global warming, and citing new research throughout, this comprehensive textbook provides key information on how animals grow and change in shape and composition, and the factors that affect these processes. Presented in a larger format with new photographs and focus boxes, this third edition continues to fill the important role of helping to understand how the basics of growth must be thoroughly understood if farm animals are to be used efficiently and humanely in producing food for mankind.

Williams Textbook of Endocrinology E-Book
Williams Textbook of Endocrinology E-Book

Author: Shlomo Melmed

Publisher: Elsevier Health Sciences

Published: 2015-11-11

Total Pages: 1944

ISBN-13: 0323341578

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For more than 65 years, Williams Textbook of Endocrinology has been the gold standard in the field, delivering authoritative guidance on every aspect of adult and pediatric endocrine system disorders. The 13th Edition has been thoroughly updated by Drs. Shlomo Melmed, Kenneth S. Polonsky, P. Reed Larsen, and Henry M. Kronenberg, to bring you state-of-the-art coverage of diabetes, metabolic syndrome, obesity, thyroid disease, testicular disorders, and much more, all designed to help you provide optimal care to every patient. Bridging the gap between basic science and clinical information, it is an essential, relevant resource for endocrinologists, endocrine surgeons, gynecologists, internists, and pediatricians – any clinician who needs the most reliable coverage available on the diverse features across the spectrum of endocrine disease. Obtain a better understanding of both scientific insight and clinical data from the classic reference that delivers the current information you need in a highly illustrated, user-friendly format. Stay up to date with expanded discussions of autoimmune thyroid diseases, mechanisms, and the appropriate treatment of the ophthalmopathy of Graves’ disease; a new section on the interpretation of fine needle aspiration results in patients with thyroid nodules; and new coverage of when and when not to use radioiodine in the treatment of patients with thyroid cancer. Update your knowledge and skills with all-new chapters on Genetics of Endocrine Disease, Endocrinology of Population Health, and Laboratory Techniques for Recognition of Endocrine Disorders. Confidently manage any clinical endocrinopathy you may encounter thanks to new information on recent FDA-approved drugs for pituitary disorders, a new focus on pediatrics, and new content on diabetes, obesity, and appetite control. Benefit from the expertise of dynamic new contributors who offer fresh perspectives throughout.

The IGF System
The IGF System

Author: Charles T. Roberts

Publisher: Firefly Books

Published: 1999-06

Total Pages: 804

ISBN-13: 9780896036925

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It has been over 40 years since the original report by Salmon and Daughaday demon strating that the ability of GH to stimulate sulfation of cartilage was mediated by a "sulfation factor. " In the ensuing decades, it has become apparent that this "sulfation factor activity" encompasses a complex system ofligands (IGFs), receptors, and carrier proteins that are, in tum, responsible for a wide array of cellular actions. The IGF system has been demonstrated to be critically involved in both intrauterine and postnatal growth, and to have important implications in cancer biology as well, owing to the ability of the IGFs to function in endocrine, paracrine, and autocrine modes and given the wide distri bution of IGFs in virtually every organ system. The contributions to The /GF System reflect the wide span of interest in the IGF system and its implications for normal and abnormal growth and metabolism. The chapters have been divided into four broad sections: I. Molecular biology of the IGF system; II. Bio logical actions of the IGFs; III. IGF physiology; and IV. Clinical aspects of the IGFs. We have made every effort to highlight the major contemporary themes in IGF biology, but as is inevitable in such a fast-moving field, perspectives will continue to change as new information is accumulated.

Growth of Farm Animals
Growth of Farm Animals

Author: Tony Lawrence, Vernon Fowler and Jan Novakofski

Publisher: CABI

Published:

Total Pages:

ISBN-13: 9781780641249

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An understanding of the processes that change the shape and composition of farm animals is fundamental to all aspects of production. Updated to include new chapters on avian growth and global warming, and citing new research throughout, this comprehensive textbook provides key information on how animals grow and change in shape and composition, and the factors that affect these processes. Presented in a larger format with new photographs and focus boxes, this third edition continues to fill the important role of helping to understand how the basics of growth must be thoroughly understood if farm animals are to be used efficiently and humanely in producing food for mankind.