Inferring Phylogenies
Inferring Phylogenies

Author: Joseph Felsenstein

Publisher: Sinauer Associates Incorporated

Published: 2004-01

Total Pages: 664

ISBN-13: 9780878931774

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Phylogenies, or evolutionary trees, are the basic structures necessary to think about and analyze differences between species. Statistical, computational, and algorithmic work in this field has been ongoing for four decades now, and there have been great advances in understanding. Yet no book has summarized this work. Inferring Phylogenies does just that in a single, compact volume. Phylogenies are inferred with various kinds of data. This book concentrates on some of the central ones: discretely coded characters, molecular sequences, gene frequencies, and quantitative traits. Also covered are restriction sites, RAPDs, and microsatellites.

The Pangenome
The Pangenome

Author: Hervé Tettelin

Publisher: Springer Nature

Published: 2020-04-30

Total Pages: 311

ISBN-13: 3030382818

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This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes. The book’s respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory. Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics.

Horizontal Gene Transfer in the Evolution of Pathogenesis
Horizontal Gene Transfer in the Evolution of Pathogenesis

Author: Michael Hensel

Publisher:

Published: 2008

Total Pages: 349

ISBN-13: 9781107178212

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Horizontal gene transfer is a major driving force in the evolution of many bacterial pathogens. The development of high-throughput sequencing tools and more sophisticated genomic and proteomic techniques in recent years has resulted in a better understanding of this phenomenon. Written by leading experts in the field, this edited volume is aimed at graduate students and researchers and provides an overview of current knowledge relating to the evolution of microbial pathogenicity. This volume provides an overview of the mechanisms and biological consequences of the genome rearrangements resulting from horizontal gene transfer, in both prokaryotes and eukaryotes, as well as overviews of the key mobile genetic elements involved. Subsequent chapters focus on paradigms for the evolution of important bacterial pathogens, including Salmonella enterica, Streptococcus pneumoniae, and Staphylococcus aureus. The influence of socioeconomic parameters in the dissemination of transferable elements, such as antibiotic resistant genes in bacteria, is also discussed.

Intracellular Parasitism
Intracellular Parasitism

Author: James W. Moulder

Publisher: CRC Press

Published: 2020-10-28

Total Pages: 287

ISBN-13: 1000098532

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This publication is a collection of essays on the biology of intracellular parasitisms where both bacterial and protozoan parasites are discussed. The juxtaposition of authors representing fields of research emphasizes the many common problems facing intracellular parasites and the hosts that harbor them. In addition, numerous illustrations of how different parasites and host attempt to solve these problems in different ways are provided. The book includes one or more chapters on Bdellovibrio, Chlamydia, Rickettsia, Coxiella, Legionella, Shigellae, Mycobacterium, Microsporidium, Plasmodium, and Toxoplasma. The authors frequently speculate and generalize on the subject matter discussed.

Lateral DNA Transfer
Lateral DNA Transfer

Author: Frederic Bushman

Publisher: CSHL Press

Published: 2002

Total Pages: 472

ISBN-13: 9780879696214

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This book is about mobile genes—the transfer of DNA between unrelated cells. It discusses the machinery of gene transfer and its wide-ranging biological and health consequences. Mobile DNA makes possible the development of antibiotic resistance in microbes, the conversion of harmless to pathogenic bacteria, and the triggering of cancerous growth in cells. It also contributes to human evolution. This well-illustrated volume contains an up-to-date account of a topic now seen as increasingly important, and will be invaluable for both working scientists and as a textbook for advanced courses.

Horizontal Gene Transfer
Horizontal Gene Transfer

Author: Tomás G. Villa

Publisher: Springer

Published: 2019-08-13

Total Pages: 422

ISBN-13: 3030218627

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The book focuses on the evolutionary impact of horizontal gene transfer processes on pathogenicity, environmental adaptation and biological speciation. Newly acquired genetic material has been considered as a driving force in evolution for prokaryotic genomes for many years, with recent technical developments advancing this field further. However, the extent and implications of gene transfer between prokaryotes and eukaryotes still raise controversies. This multi-authored volume introduces various means by which DNA can be exchanged, covers gene transfer between prokaryotes and their viruses as well as between bacteria and eukaryotes, such as fungi, plants and animals, and addresses the role of horizontal gene transfer in human diseases. Aspects discussed also include the relevance for virulence and drug resistance development on one hand, and for the occurrence of naturally derived antibiotics and other secondary metabolites on the other hand. This book offers new insights to anyone interested in genome evolution and the exchange of DNA between the different domains of life, the genetic toolkit for adaptation and the emergence of multidrug resistant bacteria.

Molecular Mechanisms of Bacterial Virulence
Molecular Mechanisms of Bacterial Virulence

Author: C.I. Kado

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 676

ISBN-13: 9401107467

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The growing body of information on bacteria pathogenic for humans, mammals and plants generated within the past ten years has shown the interesting conservation of newly identified genes that playa direct role in the pathogenic mechanism. In addition to these genes, there are also genes that confer host specificities and other traits important in pathogenesis on these pathogens. In this volume, we have organized the subject areas to best fit the concept on the way bacterial pathogens recognize, interact and invade the host, on the regulation of genes involved in virulence, on the genes involved in the elaboration of toxins and other pathogenic components such as iron sequestering proteins, and on the mechanisms of circumventing the host defense systems. These areas are divided into Sections. Section I covers the first step when the pathogen seeks its host, and Sections II through VI cover subsequent steps leading to pathogenesis while avoiding host defenses. We conclude this work with a chapter summarizing information on examples of virulence mechanisms that are highly conserved.

Microbial Evolution and Co-Adaptation
Microbial Evolution and Co-Adaptation

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2009-05-10

Total Pages: 330

ISBN-13: 0309131219

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Dr. Joshua Lederberg - scientist, Nobel laureate, visionary thinker, and friend of the Forum on Microbial Threats - died on February 2, 2008. It was in his honor that the Institute of Medicine's Forum on Microbial Threats convened a public workshop on May 20-21, 2008, to examine Dr. Lederberg's scientific and policy contributions to the marketplace of ideas in the life sciences, medicine, and public policy. The resulting workshop summary, Microbial Evolution and Co-Adaptation, demonstrates the extent to which conceptual and technological developments have, within a few short years, advanced our collective understanding of the microbiome, microbial genetics, microbial communities, and microbe-host-environment interactions.

Horizontal Gene Transfer in the Evolution of Pathogenesis
Horizontal Gene Transfer in the Evolution of Pathogenesis

Author: Michael Hensel

Publisher: Cambridge University Press

Published: 2008-06-30

Total Pages: 335

ISBN-13: 1139472054

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Horizontal gene transfer is a major driving force in the evolution of many bacterial pathogens. The development of high-throughput sequencing tools and more sophisticated genomic and proteomic techniques in recent years has resulted in a better understanding of this phenomenon. Written by leading experts in the field, this edited volume is aimed at graduate students and researchers and provides an overview of current knowledge relating to the evolution of microbial pathogenicity. This volume provides an overview of the mechanisms and biological consequences of the genome rearrangements resulting from horizontal gene transfer, in both prokaryotes and eukaryotes, as well as overviews of the key mobile genetic elements involved. Subsequent chapters focus on paradigms for the evolution of important bacterial pathogens, including Salmonella enterica, Streptococcus pneumoniae, and Staphylococcus aureus. The influence of socioeconomic parameters in the dissemination of transferable elements, such as antibiotic resistant genes in bacteria, is also discussed.

Pathogenesis of Bacterial Infections in Animals
Pathogenesis of Bacterial Infections in Animals

Author: Carlton L. Gyles

Publisher: John Wiley & Sons

Published: 2008-02-28

Total Pages: 456

ISBN-13: 0470344830

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This much-anticipated third edition again consolidates the knowledge of more than twenty experts on pathogenesis of animal disease caused by various species or groups of bacteria. Emphasizing pathogenic events at the molecular and cellular levels, the editors and contributors place these developments in the context of the overall picture of disease. Pathogenesis of Bacterial Infections in Animals, Third edition, updates and expands the content of the second edition and includes cutting-edge information from the most current research. Comments on previous editions: "...highly recommended." --The Veterinary Record "...a comprehensive, complete and easy-to-use source of information." --Veterinary Microbiology "...recommended for graduate students and specialists in microbiology, pathology and infectious disease." --U.S. Animal Health Association Newsletter "...a wonderful book." --Journal of the American Veterinary Medical Association "...highly recommended." --The Cornell Veterinarian Graduate students, faculty, researchers, and specialists in microbiology, pathology, and infectious diseases will benefit from this highly-detailed and expanded edition of a popular and well-read veterinary text.