This book reviews the recent advances in the development of proteomics-based biomarkers for the non-invasive diagnosis of altitude sickness and explores the potential of antioxidant therapy for this sickness. The first chapters introduce the associated pathophysiology and provide mechanistic insights into the enhanced generation of reactive oxygen and nitrogen species (RONS), which leads to an increase in oxidative damage to lipids, proteins, and DNA. The book then highlights the current problems relating to the diagnosis and treatment of altitude sickness and summarizes novel approaches for identifying potential biomarkers and therapeutics. Lastly, it explores the therapeutic efficacy of antioxidant agents.
Volume 1 of Computational Approaches in Bioengineering—Computational Approaches in Biotechnology and Bioinformatics—explores many significant topics of biomedical engineering and bioinformatics in an easily understandable format. It explores recent developments and applications in bioinformatics, biomechanics, artificial intelligence (AI), signal processing, wearable sensors, biomaterials, cell biology, synthetic biology, biostatistics, prosthetics, big data, and algorithms. From applications of biomaterials in advanced drug delivery systems to the role of big data, AI, and machine learning in disease diagnosis and treatment, the book will help readers understand how these technologies are being applied across the areas of biomedical engineering, bioinformatics, and healthcare. The chapters also include case studies on the role of medical robots in surgery and the determination of protein structure using genetic algorithms. The contributors are all leading experts across multiple disciplines and provide chapters that truly represent a complete view of these state-of-the-art technologies. FEATURES Covers a wide range of subjects from biomedical engineering like wearable devices, biomaterials, synthetic biology, phytochemical extraction, and prosthetics Explores AI, machine learning, big data analysis, and algorithms in biomedical engineering and bioinformatics in an easily understandable format Includes case studies on the role of medical robots in surgery and the determination of protein structure using genetic algorithms Discusses genetic diagnosis, classification, and risk prediction in cancer using next-generation sequencing in oncology This book is ideally designed for biomedical professionals, biomedical engineers, healthcare professionals, data engineers, clinicians, physicians, medical students, hospital directors, clinical researchers, and others who work in the field of artificial intelligence, bioinformatics, and computational biology.
This book gives an overview of pharmacoproteomics and its clinical applications, as well as the latest information on drug mechanisms at the proteome level, the relationship between proteomics and toxicity or resistance, and how proteomics aid in discovery of new drug targets. The book also highlights recent advances in analytical methods, analysis, and interpretation of pharmacoproteomic data. Pharmacoproteomics: Recent Trends and Applications is an ideal book for those working in pharmaceutical industries, as well as scientists, health care professionals, and researchers who work in the field of genomics, pharmacology, pharmacokinetics, toxicology, and pharmaceutical chemistry.
On December 5, 2017, the National Academies of Sciences, Engineering, and Medicine hosted a public workshop titled Nutrigenomics and the Future of Nutrition in Washington, DC, to review current knowledge in the field of nutrigenomics as it relates to nutrition. Workshop participants explored the influence of genetic and epigenetic expression on nutritional status and the potential impact of personalized nutrition on health maintenance and chronic disease prevention. This publication summarizes the presentations and discussions from the workshop.
Management of High Altitude Pathophysiology presents a comprehensive overview on the various therapeutic practices and ongoing research relating to the development of more potent and novel formulations for managing high altitude pathophysiology. It provides a detailed application of both herbal and non-herbal therapeutic agents, including their nanoformulations. This important reference provides benefits to the medical and herbal scientific communities, doctors treating patients with high altitude complications, individuals travelling to high altitudes for recreation or work, and scientists working on future drug development. - Provides the recent advances and potential therapeutic agents for ameliorating the high-altitude complications - Includes herbal remedies for the prophylaxis and treatment of the high-altitude maladies - Elucidates the significance of Yogic practices and ergonomics in managing stress at high altitude
"How long can humans live? Is immortality possible? Just what is the aging process? The aging and inevitable death of the human body have inspired more myths and outrageous quackery than anything else subject to scientific inquiry. . . . Now comes a most fascinating book, insightful and scholarly, to provide what answers have emerged so far." --San Francisco Chronicle Here, at last, preeminent cell biologist Leonard Hayflick presents the truth about human aging. Based on more than thirty years of pioneering research in the field, How and Why We Age explores not only how our major biological systems change as we grow older, but also examines the intangible alterations in our modes of thinking and feeling, our moods and sexual desires, our personality traits and our memories. With the immediacy of the latest scientific discoveries, Dr. Hayflick explains how aging affects every part of the body, and dispels many of the most persistent aging myths, to show that: * Hearts do not naturally get weaker with age. * Regular exercise and a low-fat diet won't slow aging. * Curing cancer would only add two years to the average sixty-five-year-old American life. Curing heart disease, however would add fourteen years. * Only five percent of people over the age of sixty-five are in nursing homes * No human has lived--or probably can live--past 120 years. Gracefully written, clearly organized, and packed with essential facts and statistics, How and Why We Age is a landmark study of the aging process for readers of all ages. "Written in clear, nontechnical language, it is an excellent introduction to the scientific and demographic literature on this multifacetedsubject." --Nature
High altitude physiology is one of the ignored domain of the scientific research despite of the massive scale of the problem, suggested by nearly 24% of the global population that either visits or dwells at high altitude and remain at the risk of hypoxia associated alterations in physiology. This lecture note entitled "Role of Proteomics in High altitude Pathophysiology" is designed especially for those who are interested in learning proteomics and their application in the field of high altitude physiology. It meets the needs of the proteomics studies prescribed for the high altitude physiology as it covers pathophysiology and molecular biology of high altitude sickness, proteomics as powerful tools and major proteomic advancements on pathophysiology of acute mountain sickness. This lecture notes has 5 units and can be completed in two sessions. Initially, we introduced the term hypobaric hypoxia as a socio-economic problem followed by the description of its pathophysiology. The later chapters describe the role of proteomics and key findings of our lab. Finally a last concluding chapter includes the future guidelines for improving the health benefits of the ongoing research and developing novel strategies for future research. Though this lecture note has been designed for the students of biology field, it would be useful also for clinical professionals in the early stage of their career. It would be helpful to anyone who desires to enhance their knowledge in the field of high altitude physiology.
This book describes the vast variety of xenobiotics, such as pesticides, antibiotics, antibiotic resistance genes, agrochemicals and other pollutants, their interactions with the soil environment, and the currently available strategies and techniques for soil decontamination and bioremediation. Topics covered include: transport mechanisms of pollutants along the Himalayas; use of earthworms in biomonitoring; metagenomic strategies for assessing contaminated sites; xenobiotics in the food chain; phyto-chemical remediation; biodegradation by fungi; and the use of enzymes and potential microbes in biotransformation. Accordingly, the book offers a valuable guide for scientists in the fields of environmental ecology, soil and food sciences, agriculture, and applied microbiology.
The present book is aimed to provide the readers with current trends in the field of Mycology in general and fungal biotechnology in particular. The book would be of utmost importance to students, researchers and teachers of botany, mycology, microbiology, fungal biotechnology and nanotechnology. The readers should find the book full of information and reader-friendly.
