From Auto- to Allotransplantation

From Auto- to Allotransplantation

Author: F.-C. Wei

Publisher: Karger Medical and Scientific Publishers

Published: 2016-06-28

Total Pages: 190

ISBN-13: 331805867X

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This unique publication was written by experts who have made significant contributions to the development of reconstructive microsurgery and vascularized composite allotransplantation and are likely to shape its future. The book is divided into three major sections. The first presents the state-of-the-art of autologous microsurgical reconstruction. It summarizes current achievements, highlights the shortcomings of currently available techniques, and prepares the reader for the next evolutionary step: allotransplantation. Section two is a comprehensive review of allotransplantation, from immunology to surgical techniques. Finally, for those interested in establishing a comprehensive center for vascularized composite allotransplantation, section three provides important lessons from the successful Chang Gung Vascularized Composite Allotransplantation Center. From Auto- to Allotransplantation is indeed the only up-to-date and complete reference available on the topic. Scholars and research fellows interested in transplantation will benefit greatly from this work. It is also an invaluable resource for plastic, orthopedic, hand, ENT, oromaxillofacial, and general surgeons as well as for residents.


Holland-Frei Cancer Medicine

Holland-Frei Cancer Medicine

Author: Robert C. Bast, Jr.

Publisher: John Wiley & Sons

Published: 2017-03-10

Total Pages: 2004

ISBN-13: 111900084X

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Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates


Essentials of Experimental Surgery

Essentials of Experimental Surgery

Author: H Gregerson

Publisher: CRC Press

Published: 1996-05-28

Total Pages: 798

ISBN-13: 9783718654963

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This book covers all aspects of experimental gastrointestinal research including anatomy, physiology, surgical procedures and animal experimental models As well as being a useful reference guide to established scientists, it serves as an ideal introduction to the field of gastroenterology By consulting the book, the appropriate animal species and experimental model can be chosen for physiological and pathophysiological studies


The Origins of Organ Transplantation

The Origins of Organ Transplantation

Author: Thomas Schlich

Publisher: University Rochester Press

Published: 2010

Total Pages: 368

ISBN-13: 1580463533

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This book investigates a crucial-but forgotten-episode in the history of medicine. In it, Thomas Schlich systematically documents and analyzes the earliest clinical and experimental organ transplant surgeries. In so doing he lays open the historical origins of modern transplantation, offering a new and original analysis of its conceptual basis within a broader historical context. This first comprehensive account of the birth of modern transplant medicine examines how doctors and scientists between 1880 and 1930 developed the technology and rationale for performing surgical organ replacement within the epistemological and social context of experimental university medicine. The clinical application of organ replacement, however, met with formidable obstacles even as the procedure became more widely recognized. Schlich highlights various attempts to overcome these obstacles, including immunological explanations and new technologies of immune suppression, and documents the changes in surgical technique and research standards that led to the temporary abandonment of organ transplantation by the 1930s. Thomas Schlich is professor and Canada Research Chair in the History of Medicine at McGill University.


Cancer Immunology and Immunotherapy

Cancer Immunology and Immunotherapy

Author: Glenn Dranoff

Publisher: Springer Science & Business Media

Published: 2011-04-11

Total Pages: 313

ISBN-13: 3642141366

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The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tumor-immune interactions in several human cancers that illustrate various aspects of this complexity and proposes an integrated scheme of the impact of local immune reactions on clinical outcome. Current active immunotherapy trials have shown durable tumor regressions in a fraction of patients. However, clinical efficacy of current vaccines is limited, possibly because tumors skew the immune system by means of myeloid-derived suppressor cells, inflammatory type 2 T cells and regulatory T cells (Tregs), all of which prevent the generation of effector cells. To improve the clinical efficacy of cancer vaccines in patients with metastatic disease, we need to design novel and improved strategies that can boost adaptive immunity to cancer, help overcome Tregs and allow the breakdown of the immunosuppressive tumor microenvironment.


Beta Cells in Health and Disease

Beta Cells in Health and Disease

Author: Shahzad Irfan

Publisher: BoD – Books on Demand

Published: 2024-01-17

Total Pages: 94

ISBN-13: 1837696284

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Beta Cells in Health and Disease presents the latest information on the novel and widely studied physiology of pancreatic cells in homeostasis and under pathogenic conditions. This book includes chapters on a variety of topics, including the importance and the biology of insulin hormone, pancreatic beta cell dysfunction in type 1 diabetes, the biological importance of physical activity in managing type 1 diabetes, the use of stem cell therapy for the treatment of diabetes, the role of microRNAs in modulating beta cell function, and more.


Small-Bowel Transplantation

Small-Bowel Transplantation

Author: Eberhard Deltz

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 302

ISBN-13: 3642710875

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In contrast to the continuously increasing success in kidney, liver, heart, and pancreas transplantation, small-bowel transplantation has not shown simi larly impressive progress until recently. The few clinical attempts at small-intestinal transplantation in the late 1960s and early 1970s were unsuccessful. In spite of these initial failures, a few groups of surgeons continued to investigate the problems of small-bowel transplantation from the technical, functional, and immunologic point of view. Now, about 15 years later, conditions have changed. Total parenteral nutrition has made tremendous progress, thus maintaining patients with short-bowel syndrome who are potential recipients of small-bowel grafts in an acceptable physical condition. Immunologists and clinicians have furt hermore been able to expand our knowledge of basic immunologic reactions induced by transplanted organs. In addition, within the last 8 years, new immunosuppressive drugs and regimens have been introduced which have proved to be extremely effective. Taking all these aspects into account, we regarded it as an extremely worthwhile and effective undertaking to invite scientists from all over the world who are working in the field of small-bowel transplantation to participate in a symposium on this topic. This meeting, the first to deal exclusively with small-bowel transplantation, was held in Kiel, West Ger many, in October 1985. Its aims were twofold: 1. ) To'stimulate direct communication between basic scientists and clini cians 2.


Pediatric Solid Organ Transplantation

Pediatric Solid Organ Transplantation

Author: Richard N. Fine

Publisher: John Wiley & Sons

Published: 2009-04-08

Total Pages: 488

ISBN-13: 1444312731

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Pediatric Solid Organ Transplantation is acomprehensive and succinct text on all aspects of pediatric solidorgan transplantation. It provides a ready source of reference, toboth the basic science and organ specific surgical technique andafter care. This second edition has been extensively updated inlight of recent developments in this rapidly advancing area. The only textbook devoted to the field of pediatrictransplantation A definitive reference for all those interested in improvingthe care and quality of life of children undergoing solid organtransplantation Section on immunosuppression has been expanded by four chaptersto include sections on; - mechanisms of action - therapies for the sensitized patient - post-transplant lymphoproliferative disorders - organ toxicities of immunosuppressive therapy A new section has been added on the many topics related toquality of life that effect survivors of pediatrictransplantation International editorial and contributor team represents a widegeographical range and contains both recognized leaders andemerging experts Whether you are an established sub-specialist in pediatrictransplantation, a transplant surgeon, or a pediatric specialist ina related area, this book will answer all your questions about careof the pediatric patient before, during, and aftertransplantation.