Expression and Survival
Expression and Survival

Author: Craig Greenman

Publisher: Cambridge Scholars Publishing

Published: 2009-03-26

Total Pages: 110

ISBN-13: 1443807850

DOWNLOAD EBOOK

Philosophers know suicide primarily as an ethical problem. But in Expression and Survival, Craig Greenman argues that, when it comes to suicide, the standard ethical approach may do more harm than good. He develops instead an aesthetic approach, arguing that art–making it or experiencing it–can help a suicidal person survive. Drawing on the work of philosophers and artists, as well as his own experiences, Greenman guides the reader through the landscape to which many suicidal people feel condemned. He traces the problem back to antagonism–we harm others and they harm us–and argues that art, broadly construed, can help us survive it. The result will be of interest to ethicists, aestheticians, social and political philosophers, therapists, and anyone who has ever struggled with suicide. Also included in this volume are two essays, “Writing and Ambivalence” and “What Is Philosophy?”

RSEM: Accurate Transcript Quantification from RNA-Seq Data with Or Without a Reference Genome
RSEM: Accurate Transcript Quantification from RNA-Seq Data with Or Without a Reference Genome

Author: Applied Research Applied Research Press

Publisher:

Published: 2015-09-16

Total Pages: 44

ISBN-13: 9781517392185

DOWNLOAD EBOOK

RNA-Seq is revolutionizing the way transcript abundances are measured. A key challenge in transcript quantification from RNA-Seq data is the handling of reads that map to multiple genes or isoforms. This issue is particularly important for quantification with de novo transcriptome assemblies in the absence of sequenced genomes, as it is difficult to determine which transcripts are isoforms of the same gene. A second significant issue is the design of RNA-Seq experiments, in terms of the number of reads, read length, and whether reads come from one or both ends of cDNA fragments. RSEM is an accurate and user-friendly software tool for quantifying transcript abundances from RNA-Seq data. As it does not rely on the existence of a reference genome, it is particularly useful for quantification with de novo transcriptome assemblies. In addition, RSEM has enabled valuable guidance for cost-efficient design of quantification experiments with RNA-Seq, which is currently relatively expensive.

Introducing Survival and Event History Analysis
Introducing Survival and Event History Analysis

Author: Melinda Mills

Publisher: SAGE

Published: 2011-01-19

Total Pages: 301

ISBN-13: 1848601026

DOWNLOAD EBOOK

This book is an accessible, practical and comprehensive guide for researchers from multiple disciplines including biomedical, epidemiology, engineering and the social sciences. Written for accessibility, this book will appeal to students and researchers who want to understand the basics of survival and event history analysis and apply these methods without getting entangled in mathematical and theoretical technicalities. Inside, readers are offered a blueprint for their entire research project from data preparation to model selection and diagnostics. Engaging, easy to read, functional and packed with enlightening examples, ‘hands-on’ exercises, conversations with key scholars and resources for both students and instructors, this text allows researchers to quickly master advanced statistical techniques. It is written from the perspective of the ‘user’, making it suitable as both a self-learning tool and graduate-level textbook. Also included are up-to-date innovations in the field, including advancements in the assessment of model fit, unobserved heterogeneity, recurrent events and multilevel event history models. Practical instructions are also included for using the statistical programs of R, STATA and SPSS, enabling readers to replicate the examples described in the text.

Implementing Reproducible Research
Implementing Reproducible Research

Author: Victoria Stodden

Publisher: CRC Press

Published: 2014-04-14

Total Pages: 450

ISBN-13: 1466561599

DOWNLOAD EBOOK

In computational science, reproducibility requires that researchers make code and data available to others so that the data can be analyzed in a similar manner as in the original publication. Code must be available to be distributed, data must be accessible in a readable format, and a platform must be available for widely distributing the data and code. In addition, both data and code need to be licensed permissively enough so that others can reproduce the work without a substantial legal burden. Implementing Reproducible Research covers many of the elements necessary for conducting and distributing reproducible research. It explains how to accurately reproduce a scientific result. Divided into three parts, the book discusses the tools, practices, and dissemination platforms for ensuring reproducibility in computational science. It describes: Computational tools, such as Sweave, knitr, VisTrails, Sumatra, CDE, and the Declaratron system Open source practices, good programming practices, trends in open science, and the role of cloud computing in reproducible research Software and methodological platforms, including open source software packages, RunMyCode platform, and open access journals Each part presents contributions from leaders who have developed software and other products that have advanced the field. Supplementary material is available at www.ImplementingRR.org.

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research
Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research

Author: National Research Council

Publisher: National Academies Press

Published: 2003-08-22

Total Pages: 223

ISBN-13: 030916785X

DOWNLOAD EBOOK

Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.

Survival Analysis with Python
Survival Analysis with Python

Author: Avishek Nag

Publisher: CRC Press

Published: 2021-12-17

Total Pages: 94

ISBN-13: 1000520676

DOWNLOAD EBOOK

Survival analysis uses statistics to calculate time to failure. Survival Analysis with Python takes a fresh look at this complex subject by explaining how to use the Python programming language to perform this type of analysis. As the subject itself is very mathematical and full of expressions and formulations, the book provides detailed explanations and examines practical implications. The book begins with an overview of the concepts underpinning statistical survival analysis. It then delves into Parametric models with coverage of Concept of maximum likelihood estimate (MLE) of a probability distribution parameter MLE of the survival function Common probability distributions and their analysis Analysis of exponential distribution as a survival function Analysis of Weibull distribution as a survival function Derivation of Gumbel distribution as a survival function from Weibull Non-parametric models including Kaplan–Meier (KM) estimator, a derivation of expression using MLE Fitting KM estimator with an example dataset, Python code and plotting curves Greenwood’s formula and its derivation Models with covariates explaining The concept of time shift and the accelerated failure time (AFT) model Weibull-AFT model and derivation of parameters by MLE Proportional Hazard (PH) model Cox-PH model and Breslow’s method Significance of covariates Selection of covariates The Python lifelines library is used for coding examples. By mapping theory to practical examples featuring datasets, this book is a hands-on tutorial as well as a handy reference.

Hegemony or Survival
Hegemony or Survival

Author: Noam Chomsky

Publisher: Macmillan + ORM

Published: 2007-04-01

Total Pages: 324

ISBN-13: 1429900210

DOWNLOAD EBOOK

From the world's foremost intellectual activist, an irrefutable analysis of America's pursuit of total domination and the catastrophic consequences that are sure to follow The United States is in the process of staking out not just the globe but the last unarmed spot in our neighborhood-the heavens-as a militarized sphere of influence. Our earth and its skies are, for the Bush administration, the final frontiers of imperial control. In Hegemony or Survival , Noam Chomsky investigates how we came to this moment, what kind of peril we find ourselves in, and why our rulers are willing to jeopardize the future of our species. With the striking logic that is his trademark, Chomsky dissects America's quest for global supremacy, tracking the U.S. government's aggressive pursuit of policies intended to achieve "full spectrum dominance" at any cost. He lays out vividly how the various strands of policy-the militarization of space, the ballistic-missile defense program, unilateralism, the dismantling of international agreements, and the response to the Iraqi crisis-cohere in a drive for hegemony that ultimately threatens our survival. In our era, he argues, empire is a recipe for an earthly wasteland. Lucid, rigorous, and thoroughly documented, Hegemony or Survival promises to be Chomsky's most urgent and sweeping work in years, certain to spark widespread debate.

Survival of the Sickest LP
Survival of the Sickest LP

Author: Dr. Sharon Moalem

Publisher: Harper Collins

Published: 2007-05-22

Total Pages: 370

ISBN-13: 0061232963

DOWNLOAD EBOOK

Was diabetes evolution's response to the last Ice Age? Did a deadly genetic disease help our ancestors survive the bubonic plagues of Europe? Will a visit to the tanning salon help lower your cholesterol? Why do we age? Why are some people immune to HIV? Can your genes be turned on—or off? Survival of the Sickest is fi lled with fascinating insights and cutting-edge research, presented in a way that is both accessible and utterly absorbing. This is a book about the interconnectedness of all life on earth—and especially what that means for us. Read it. You're already living it.