Effects of Negative Affect, Caregiving Stress, and Cardiovascular Risk Factors on Coagulation Responses to Acute Psychological Stress

Effects of Negative Affect, Caregiving Stress, and Cardiovascular Risk Factors on Coagulation Responses to Acute Psychological Stress

Author: Kristin Aschbacher

Publisher:

Published: 2009

Total Pages: 270

ISBN-13:

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Research suggests that depression is associated with heightened risk of cardiovascular morbidity and mortality, independent of sociodemographic, behavioral and medical factors. Chronic stressors, such as caring for a spouse with Alzheimer's disease may contribute to CVD risk, partly through increased symptoms of negative affect and heightened platelet activation. Objectives: (1) To investigate cross-sectional and longitudinal associations between negative affect and platelet activation. (2) To investigate whether the magnitude of these associations is greater among dementia caregivers compared to non-caregivers. (3) To explore the impact of age, gender, preexisting cardiovascular disease, and medication usage (particularly Hormone Replacement Therapy) on platelet activation among caregivers. This study utilized a pre-existing data set consisting of 99 caregivers and 50 non-caregivers (average age 71 years), who were assessed over a 3-year period. Caregiver burden and negative affect were assessed using the Role Overload Instrument and the depressive and anxious symptom subscales of the Brief Symptom Inventory. Plasma norepinephrine levels were assayed using enzyme linked immunoabsorbent assay (ELISA). Three measures of platelet activation were obtained through flow cytometric analyses: (1) Glycoprotein IIb/IIIa expression, (2) P-selectin expression, and (3) % platelet aggregates. In order to elicit platelet and norepinephrine reactivity, participants completed an acute stress test, and blood was drawn at three time-points (baseline, post-speech, and after 14 minutes of recovery). Four separate studies are presented as separate manuscripts. The results establish that depressive and anxious symptoms were significantly related to norepinephrine and platelet activation in response to acute stress among caregivers but not among non-caregivers. Methodological findings support the validity of the acute stress test as a tool for provoking platelet activation in longitudinal designs. The combined influence of hormone replacement therapy and caregiving stress was associated with prolonged platelet activation among post-menopausal women. Persistent assessments of negative affect bore stronger and more consistent relationships to platelet activity than transient assessments. In sum, exaggerated platelet activation in response to stress, affect, or pharmacological risk may contribute to the development or evolution of cardiovascular disease processes, under conditions of chronic stress such as caregiving.


Stress and Cardiovascular Disease

Stress and Cardiovascular Disease

Author: Paul Hjemdahl

Publisher: Springer Science & Business Media

Published: 2011-10-01

Total Pages: 389

ISBN-13: 184882419X

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The main aim of this book is to evaluate the concept of stress and provide tools for physicians to identify patients who might benefit from stress management. This will incorporate a detailed description of the physiological and pathophysiological consequences of acute and chronic stress that might lead to cardiovascular disease. The book will aim to critically evaluate interventional research (behavioural and other therapies) and provide evidence based recommendations on how to manage stress in the cardiovascular patient. Our intentions are to define and highlight stress as an etiological factor for cardiovascular disease, and to describe an evidence based "tool box" that physicians may use to identify and manage patients in whom stress may be an important contributing factor for their disease and their risk of suffering cardiovascular complications.


Pituitary Adenylate Cyclase-Activating Polypeptide

Pituitary Adenylate Cyclase-Activating Polypeptide

Author: Hubert Vaudry

Publisher: Springer Science & Business Media

Published: 2003

Total Pages: 432

ISBN-13: 9781402073069

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Pituitary Adenylate Cyclase-Activating Polypeptide is the first volume to be written on the neuropeptide PACAP. It covers all domains of PACAP from molecular and cellular aspects to physiological activities and promises for new therapeutic strategies. Pituitary Adenylate Cyclase-Activating Polypeptide is the twentieth volume published in the Endocrine Updates book series under the Series Editorship of Shlomo Melmed, MD.


How Tobacco Smoke Causes Disease

How Tobacco Smoke Causes Disease

Author: United States. Public Health Service. Office of the Surgeon General

Publisher:

Published: 2010

Total Pages: 728

ISBN-13:

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This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.


Trauma Induced Coagulopathy

Trauma Induced Coagulopathy

Author: Hunter B. Moore

Publisher: Springer Nature

Published: 2020-10-12

Total Pages: 802

ISBN-13: 3030536068

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The first edition of this publication was aimed at defining the current concepts of trauma induced coagulopathy by critically analyzing the most up-to-date studies from a clinical and basic science perspective. It served as a reference source for any clinician interested in reviewing the pathophysiology, diagnosis, and management of the coagulopathic trauma patient, and the data that supports it. By meticulously describing the methodology of most traditional as well as state of the art coagulation assays the reader is provided with a full understanding of the tests that are used to study trauma induced coagulopathy. With the growing interest in understanding and managing coagulation in trauma, this second edition has been expanded to 46 chapters from its original 35 to incorporate the massive global efforts in understanding, diagnosing, and treating trauma induced coagulopathy. The evolving use of blood products as well as recently introduced hemostatic medications is reviewed in detail. The text provides therapeutic strategies to treat specific coagulation abnormalities following severe injury, which goes beyond the first edition that largely was based on describing the mechanisms causing coagulation abnormalities. Trauma Induced Coagulopathy 2nd Edition is a valuable reference to clinicians that are faced with specific clinical challenges when managing coagulopathy.


Handbook of Behavioral Medicine

Handbook of Behavioral Medicine

Author: Andrew Steptoe

Publisher: Springer Science & Business Media

Published: 2010-09-27

Total Pages: 1054

ISBN-13: 0387094881

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Behavioral medicine emerged in the 1970s as the interdisciplinary field concerned with the integration of behavioral, psychosocial, and biomedical science knowledge relevant to the understanding of health and illness, and the application of this knowledge to prevention, diagnosis, treatment, and rehabilitation. Recent years have witnessed an enormous diversification of behavioral medicine, with new sciences (such as genetics, life course epidemiology) and new technologies (such as neuroimaging) coming into play. This book brings together such new developments by providing an up-to-date compendium of methods and applications drawn from the broad range of behavioral medicine research and practice. The book is divided into 10 sections that address key fields in behavioral medicine. Each section begins with one or two methodological or conceptual chapters, followed by contributions that address substantive topics within that field. Major health problems such as cardiovascular disease, cancer, HIV/AIDs, and obesity are explored from multiple perspectives. The aim is to present behavioral medicine as an integrative discipline, involving diverse methodologies and paradigms that converge on health and well being.


Stress Proof the Heart

Stress Proof the Heart

Author: Ellen A. Dornelas

Publisher: Springer Science & Business Media

Published: 2012-02-01

Total Pages: 410

ISBN-13: 1441956506

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Cardiovascular disease is a leading cause of death throughout the world. Chronic negative emotions such as depression and anxiety place cardiac patients at greater risk for death and recurrence of cardiovascular disease. In 2008 the editor published a book related to this topic, titled Psychotherapy with Cardiac Patients: Behavioral Cardiology in Practice (American Psychological Association). Aside from that book, there are very few resources specifically written for clinicians who treat psychologically distressed cardiac patients. Unlike other medical specialty areas such as oncology, the field of cardiology has been slow to integrate behavioral treatments into the delivery of service. Perhaps because the field has been largely defined and dominated by researchers, mental health clinicians are only starting to recognize behavioral cardiology as a viable arena in which to practice. There is a large void in the practitioner literature on behavioral cardiology. In a review of Psychotherapy with Cardiac Patients, Paul Efthim, Ph.D. wrote, "Her new book goes well beyond previous works by giving specific and detailed guidance about how to tailor psychological interventions with this variegated population." He added, "It would benefit from even more details about treatment approaches." This proposed volume goes beyond the editor’s previous volume by providing in-depth descriptions of behavioral treatments for distressed cardiac patients written by eminent leaders in behavioral cardiology. This book describes a wide range of behavioral treatments for the common psychologically based problems encountered by clinicians who treat cardiac patients. The book is organized as follows: Part I focuses on the most psychologically challenging and common presentations of cardiac diagnosis; coronary artery disease, arrhythmia, and heart failure. This section also includes a chapter on heart transplantation, which is a treatment, not a diagnosis, but a treatment that incurs profound psychological impact for the individual. In Part II, behavioral interventions for the general cardiac population are described. Mainstream therapies such as stress management, cognitive-behavioral therapy, and medical family therapy are described, along with approaches that have less empirical support but considerable practical significance such as personality-guided therapy and interventions aimed at altering type D personality traits. The literature in behavioral cardiology has a rich history of investigating maladaptive personality traits and thus it is important to include behavioral approaches that target personality in this volume. Part III focuses on common behavioral problems encountered by clinicians who work with this patient population. Most patients who seek psychological help do so because they perceive themselves to be stressed due to their job or overextended in all areas of their life. Other people with heart disease present with sleep problems and/or an inability to motivate themselves to exercise or quit smoking. There are many practical behavioral approaches that can be helpful for patients with these difficulties and these are detailed in this section of the book. The conclusion of the book focuses on how to integrate the behavioral treatments described in the preceding chapters into a comprehensive treatment model.


Clinical Psychology and Heart Disease

Clinical Psychology and Heart Disease

Author: E. Molinari

Publisher: Springer Science & Business Media

Published: 2010-01-12

Total Pages: 510

ISBN-13: 8847003784

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This comprehensve review of scientific research supporting evidence of the relationship between cardiac disease and psychological condition offers practical suggestions for developing a clinical practice, and proposes directions for future research in the new field of "cardiac psychology". Every chapter is written by world-renowned researchers in the field. A theoretical and practical guide, it will interest physicians, clinical and health psychologists, and all professionals who seek to understand the mind-health link.


Index Medicus

Index Medicus

Author:

Publisher:

Published: 2004

Total Pages: 2002

ISBN-13:

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Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.


Wound Healing

Wound Healing

Author: Luisa A. DiPietro

Publisher: Springer Science & Business Media

Published: 2008-02-01

Total Pages: 457

ISBN-13: 1592593321

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During the past decade, significant progress in molecular and cellular te- niques has greatly advanced our understanding of the wound healing p- cess. Many of these new techniques have been utilized in the context of more classic models of wound healing. The combination of new and classic approaches has allowed scientists to make exciting discoveries in the field of tissue repair, resulting in an explosion of information about the healing p- cess. Importantly, these new findings have great relevance beyond wound healing itself. The injury repair process cuts across many disciplines, exte- ing to such broad fields as cancer, inflammation, and atherosclerosis. The relevance of the field to these many disciplines has generated great interest in models and methods for the study of wound healing. The goal of Wound Healing: Methods and Protocols is to provide scientists from many dis- plines with a compendium of classic and contemporary protocols from r- ognized experts in the field of wound healing. We hope this volume will be useful not only to those working within the field itself, but also to scientists from other disciplines who wish to adapt wound healing models to their own experimental needs. The process of wound healing encompasses many different biologic p- cesses, including epithelial growth and differentiation, fibrous tissue prod- tion and function, angiogenesis, and inflammation.