The present book consists of three parts: discovery, development and production of drugs from marine organisms. Marine bacteria, fungi, microalgae, sponges and opisthobranch mollusks have attracted much attention as sources of potential drugs, which is described in the first part. A pain-killing drug developed from the venom of a cone shell is a recent highlight of marine natural product research; the interesting story of its discovery is provided. The second part features an anticancer drug with a novel mode of action which was originally isolated from a songe and a potential antiosteoporotic drug of a hexacoral origin. But the most serious problem for development of drugs from the sea remains supply. Two possible solutions, production by fermentation and by aquaculture, are described in the third part. Identification and culture of symbiotic bacteria which are responsible for the production of bioactive sponge metabolites are the main objectives for many researchers.
When viewed from a quiet beach, the ocean can seem calm, even serene. But hidden beneath the sea's waves are a staggering variety of active creatures, engaged in the never-ending struggles of life--to reproduce, to eat, and to avoid being eaten. Marine scientist Ellen Prager takes us deep into the sea to introduce a cast of fascinating and bizarre creatures. From the tiny arrow worms whose voracious ways may lead to death by overeating, to the lobsters that battle rivals or seduce mates with their urine, Prager reveals the ways they interact as predators, prey, or potential mates. And while these animals make for some jaw-dropping stories--there's far more to Prager's account than entertaining anecdotes: again and again, she illustrates the crucial connections between life in the ocean and humankind, in everything from our food supply to our economy, and in drug discovery, biomedical research, and popular culture.--From publisher description.
This timely desk reference focuses on marine-derived bioactive substances which have biological, medical and industrial applications. The medicinal value of these marine natural products are assessed and discussed. Their function as a new and important resource in novel, anticancer drug discovery research is also presented in international contributions from several research groups. For example, the potential role of Spongistatin, Apratoxin A, Eribulin mesylate, phlorotannins, fucoidan, as anticancer agents is explained. The mechanism of action of bioactive compounds present in marine algae, bacteria, fungus, sponges, seaweeds and other marine animals and plants are illustrated via several mechanisms. In addition, this handbook lists various compounds that are active candidates in chemoprevention and their target actions. The handbook also places into context the demand for anticancer nutraceuticals and their use as potential anti-cancer pharmaceuticals and medicines. This study of advanced and future types of natural compounds from marine sources is written to facilitate the understanding of Biotechnology and its application to marine natural product drug discovery research.
Pharmaceuticals in Marine and Coastal Environments: Occurrence, Effects, and Challenges in a Changing World is divided into three sections that address a) coastal areas as the main entrance of pharmaceuticals into the ocean, b) the occurrence and distribution of pharmaceuticals in the environmental compartments of the ocean media, and c) the effects that such pollutants may cause to the exposed marine organisms. With its comprehensive discussions, the book provides a wide depiction of the current state-of-the-art on these topics in an effort to open new sources of investigation and find suitable solutions. - Includes maps edited by the Water Information Network System of the International Hydrological Program (IHP-WINS) - Provides a compilation of information regarding the occurrence and distribution of pharmaceuticals in the marine environment which will help establish new and more efficient monitoring programs and new research lines - Depicts the most important results of environmental risk assessments that can be used as a first step for further toxicological studies
This book offers a comprehensive study of biological molecules acquired from marine organisms, which have been exploited for drug discovery with the aim to treat human diseases. Biomolecules have potential impacts on a diverse range of fields, including medical and pharmaceutical science, industrial science, biotechnology, basic research, molecular science, environmental science and climate change, etc. To understand and effectively apply medicinally important biomolecules, multidisciplinary approaches are called for. The ocean remains a rich biological resource, and the vast untapped potential of novel molecules from marine bio-resources has caught the interest of more and more researchers. These novel biological compounds have never been found in terrestrial or other ecosystems, but only in this rich niche. Advances in sampling techniques and technologies, along with increased funding for research and nature conservation, have now encouraged scientists to look deeper in the waters. Aquaculture supports both tremendous seafood production and the bulk production of marine-derived drugs. Furthermore, molecular methods are now being extensively employed to explore the untapped marine microbial diversity. With the help of molecular and biotech tools, the ability of marine organisms to produce new biosynthetic drugs can be greatly enhanced. This book provides an extensive compilation of the latest information on marine resources and their undisputedly vital role in the treatment of diverse ailments.
Miller takes readers on an eye-opening tour of psychotropic drugs, describing the various kinds, how they were discovered and developed, and how they have played multiple roles in virtually every culture.
With an account of over 6.000 recent and 15.000 fossil species, phylum Bryozoa represents a quite large and important phylum of colonial filter feeders. This volume of the series Handbook of Zoology contains new findings on phylogeny, morphology and evolution that have significantly improved our knowledge and understanding of this phylum. It is a comprehensive book that will be a standard for many specialists but also newcomers to the field of bryozoology.
In the late 1970s and early '80s, a cadre of freewheeling, Southern pot smugglers lived at the crossroads of Miami Vice and a Jimmy Buffett song. These irrepressible adventurers unloaded nearly a billion dollars worth of marijuana and hashish through the eastern seaboard’s marshes. Then came their undoing: Operation Jackpot, one of the largest drug investigations ever and an opening volley in Ronald Reagan’s War on Drugs. In Jackpot, author Jason Ryan takes us back to the heady days before drug smuggling was synonymous with deadly gunplay. During this golden age of marijuana trafficking, the country’s most prominent kingpins were a group of wayward and fun-loving Southern gentlemen who forsook college educations to sail drug-laden luxury sailboats across the Mediterranean, the Atlantic, and the Caribbean. Les Riley, Barry Foy, and their comrades eschewed violence as much as they loved pleasure, and it was greed, lust, and disaster at sea that ultimately caught up with them, along with the law. In a cat-and-mouse game played out in exotic locations across the globe, the smugglers sailed through hurricanes, broke out of jail and survived encounters with armed militants in Colombia, Grenada and Lebanon. Based on years of research and interviews with imprisoned and recently released smugglers and the law enforcement agents who tracked them down, Jackpot is sure to become a classic story from America's controversial Drug Wars. “The adventures, the long-gone economy, and the sting that ultimately brought them down and changed US drug policy are meticulously documented and lucidly spun…. Part New Yorker feature-part Jimmy Buffet song. . . . The result is adventuresome, lavish, informative fun.” —GQ “[A] rollicking story, Ryan manages to pack in one amusing tale after another.... Jackpot is a rip-roaring good read.” —Charleston City Paper “High times on the high seas: Investigative reporter Ryan recounts the glory days of dope smuggling and their terrible denouement.... A well-told tale of true crime that provides a few good arguments for why it should not be a crime at all.” —Kirkus Reviews “Reads like an international thriller. . . . chock-a-block with hilarious and hair-raising anecdotes of fast times.” —New York Journal of Books “[A] thoroughly researched account of Operation Jackpot, the drug investigation that ended the reign of South Carolina’s ‘gentlemen smugglers,’.... Ryan recreates the era with a vivid, sun-drenched intensity.” —Publishers Weekly
Red Crew is a first-hand account of U.S. Coast Guard anti-smuggling operations during the early years of the nation’s maritime war on drugs. Jim Howe describes his experience as the executive officer of a specialized drug-hunting crew that sailed in then-state-of-the-art “surface effect ships,” a small flotilla of high-speed vessels pressed into the drug war on short notice. In the early 1980s, South Florida and the Caribbean were awash in illicit drugs, with hundreds of smuggling organizations bringing huge loads of marijuana, and later cocaine, into the United States. To fight this epidemic, the Reagan administration led a massive effort to disrupt shore-side gangs while bolstering interdiction activity at sea. To increase the number of days at sea for each surface effect ship, a “multi-crewing” concept was employed, with four teams of sixteen sailors—the Red, Blue, Green, and Gold Crews—rotating among three hulls. Through its first-person narrative, Red Crew offers a rare glimpse into the day-to-day pressures, challenges, failures, and successes of Coast Guard cuttermen as they carried out complex and dangerous missions. Red Crew provides a unique historical view of the early days in the Coast Guard’s war on drugs, and is the only book-length history of the diminutive, one-of-a-kind surface effect ship fleet.
