Code of Federal Regulations
Code of Federal Regulations

Author: Department of Energy (DoE) Staff

Publisher: National Archives and Records Administration

Published: 2005-03

Total Pages: 592

ISBN-13: 9780160738326

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The Code of Federal Regulations is a codification of the general and permanent rules published in the Federal Register by the Executive departments and agencies of the United States Federal Government..

Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals
Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals

Author: National Research Council

Publisher: National Academies Press

Published: 2001-06-25

Total Pages: 225

ISBN-13: 030907553X

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Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals contains a detailed and comprehensive methodology for developing acute exposure guideline levels (AEGLs) for toxic substances from inhalation exposures. The book provides guidance on what documents and databases to use, toxicity endpoints that need to be evaluated, dosimetry corrections from animal to human exposures, selection of appropriate uncertainty factors to address the variability between animals and humans and within the human population, selection of modifying factors to address data deficiencies, time scaling, and quantitative cancer risk assessment. It also contains an example of a summary of a technical support document and an example of AEGL derivation. This book will be useful to persons in the derivation of levels from other exposure routesâ€"both oral and dermalâ€"as well as risk assessors in the government, academe, and private industry.