Interpreting Difficult History at Museums and Historic Sites is framed by educational psychoanalytic theory and positions museum workers, public historians, and museum visitors as learners. Through this lens, museum workers and public historians can develop compelling and ethical representations of historical individuals, communities, and populations who have suffered. It includes various examples of difficult knowledge, detailed examples of specific interpretation methods, and will give readers an in-depth explanation of the psychoanalytic educational theories behind the methodologies. Audiences can more responsibly and productively engage in learning histories of oppression and trauma when they are in measured and sensitive museum learning environments and public history venues. To learn more, check out the website here: http://interpretingdifficulthistory.com/
Presents an extensive sample of single family homes that have adopted an active attitude in response to a difficult or uncomfortable site. Includes Harry Seidler's house in the Southern Highlands, NSW.
The 10th-anniversary edition of the New York Times business bestseller-now updated with "Answers to Ten Questions People Ask" We attempt or avoid difficult conversations every day-whether dealing with an underperforming employee, disagreeing with a spouse, or negotiating with a client. From the Harvard Negotiation Project, the organization that brought you Getting to Yes, Difficult Conversations provides a step-by-step approach to having those tough conversations with less stress and more success. you'll learn how to: · Decipher the underlying structure of every difficult conversation · Start a conversation without defensiveness · Listen for the meaning of what is not said · Stay balanced in the face of attacks and accusations · Move from emotion to productive problem solving
“Biobetters: Protein Engineering to Approach the Curative” discusses the optimization of protein therapeutic products for treatment of human diseases. It is based on the fact that though numerous important therapeutic protein products have been developed for life threatening and chronic diseases that possess acceptable safety and efficacy profiles, these products have generally not been reexamined and modified for an improved clinical performance, with enhancements both to safety and efficacy profiles. Advances in protein engineering, coupled with greatly enhanced understanding of critical product quality attributes for efficacy and safety, make it possible to optimize predecessor products for clinical performance, thereby enhancing patient quality of life and with the potential for great savings in health care costs. Yet despite such knowledge, there is little movement towards such modifications. This book examines engineering protein therapeutic products such that they exhibit an optimal, not just an adequate, clinical performance profile. Two product classes, therapeutic enzymes for lysosomal storage diseases (enzyme replacement therapies, ERT) and monoclonal antibodies (mAbs), are used as examples of what modifications to such proteins could be made to enhance clinical performance, “closer to a cure” as it were. For ERT, the key to optimizing clinical performance is to ensure the ERT is endowed with moieties that target the protein to the relevant target tissue. Thus, for Gaucher Disease, our best example of how to optimize an ERT to address a disease that manifests in specific target tissues (macrophages and monocytes), the enzyme has been extensively modified to target macrophages. For diseases such as Pompe Disease, largely a disorder of muscle, optimal performance of ERT will depend on endowing the enzyme with the ability to be taken up via the Mannose 6 Phosphate Receptor, and so one of the chapters in the book will discuss such approaches. Moreover, a major failure of biotechnology based products is to gain access to the CNS, a key target tissue in numerous diseases. Thus, a chapter has been devoted to strategies to access the CNS. Additionally, immune responses to therapeutic proteins can be highly problematic, eliminating the efficacy of life saving or highly effective protein therapeutics. This is especially poignant in the case of Pompe Disease wherein great improvement in muscle strength and functionality is lost following development of an immune response to the ERT with consequent patient deterioration and death. Thus, a chapter regarding protein engineering, as well as other non-clinical approaches to diminishing immunogenicity is a valuable part of the book. Monoclonal antibodies (mAbs) can be engineered to bind targets relevant to a wide variety of diseases; binding affinity, however, is only part of the equation and one of the chapters will present a molecular assessment approach that balances affinity with pharmacokinetics and manufacturability. As with other proteins immunogenicity can be problematic, being responsible for loss of efficacy of anti-TNF mAbs, often after prolonged successful treatment. The authors will also share their perspective on the consequences of physico-chemical modifications occurring to mAbs once they reach the circulation or their target, a research area open to further development from a protein engineering as well as analytical perspective. This book will also discuss novel platforms for protein therapeutics, technologies that exceed mAbs with respect to potency, and hence, potentially efficacy. These platforms consist largely of repeat domain proteins with very high affinity for their target ligands, but while potentially more efficacious, immunogenicity may be a major problem limiting use. The economics surrounding the issue of biobetters is another high-profile issue - this final chapter will explore the incentives and disincentives for developing biobetters and consider incentives that might make their pursuit more rewarding.
Architectural design can play a role in helping make the past present in meaningful ways when applied to preexisting buildings and places that carry notable and troubling pasts. In this comparative analysis, Rumiko Handa establishes the critical role architectural designs play in presenting difficult pasts by examining documentation centers on National Socialism in Germany. Presenting Difficult Pasts Through Architecture analyzes four centers – Cologne, Nuremberg, Berlin, and Munich – from the point of view of their shared intent to make the past present at National Socialists' perpetrator sites. Applying original frameworks, Handa considers what more architectural design could do toward meaningful representations and interpretations of difficult pasts. This book is a must-read for students, practitioners, and academics interested in how architectural design can participate in presenting the difficult pasts of historical places in meaningful ways.
From the New York Times bestselling author Kristin Hannah comes a powerful novel of love, loss, and the magic of friendship. . . . now a #1 Netflix series! In the turbulent summer of 1974, Kate Mularkey has accepted her place at the bottom of the eighth-grade social food chain. Then, to her amazement, the "coolest girl in the world" moves in across the street and wants to be her friend. Tully Hart seems to have it all---beauty, brains, ambition. On the surface they are as opposite as two people can be: Kate, doomed to be forever uncool, with a loving family who mortifies her at every turn. Tully, steeped in glamour and mystery, but with a secret that is destroying her. They make a pact to be best friends forever; by summer's end they've become TullyandKate. Inseparable. So begins Kristin Hannah's magnificent new novel. Spanning more than three decades and playing out across the ever-changing face of the Pacific Northwest, Firefly Lane is the poignant, powerful story of two women and the friendship that becomes the bulkhead of their lives. From the beginning, Tully is desperate to prove her worth to the world. Abandoned by her mother at an early age, she longs to be loved unconditionally. In the glittering, big-hair era of the eighties, she looks to men to fill the void in her soul. But in the buttoned-down nineties, it is television news that captivates her. She will follow her own blind ambition to New York and around the globe, finding fame and success . . . and loneliness. Kate knows early on that her life will be nothing special. Throughout college, she pretends to be driven by a need for success, but all she really wants is to fall in love and have children and live an ordinary life. In her own quiet way, Kate is as driven as Tully. What she doesn't know is how being a wife and mother will change her . . . how she'll lose sight of who she once was, and what she once wanted. And how much she'll envy her famous best friend. . . . For thirty years, Tully and Kate buoy each other through life, weathering the storms of friendship---jealousy, anger, hurt, resentment. They think they've survived it all until a single act of betrayal tears them apart . . . and puts their courage and friendship to the ultimate test. Firefly Lane is for anyone who ever drank Boone's Farm apple wine while listening to Abba or Fleetwood Mac. More than a coming-of-age novel, it's the story of a generation of women who were both blessed and cursed by choices. It's about promises and secrets and betrayals. And ultimately, about the one person who really, truly knows you---and knows what has the power to hurt you . . . and heal you. Firefly Lane is a story you'll never forget . . . one you'll want to pass on to your best friend.
Since 1939, the Symposium Neuroradiologicum has been held every 4 years in various cities throughout the world. Great neuroradiologists such as Taveras, Du Boulay, Greitz, Lindgren, and DiChiro have been among the presidents of the previous symposia. The XV Symposium Neuroradiologicum was held in Kumamoto from 25 September through 1 October 1994. More than 1,200 participants gathered to discuss the most recent developments, including interventional neuroradiology, functional imaging, MRI contrast media, new techniques in MRI, iodinated contrast media and other advances. The communications are presented in this book. Special lectures held by Drs. Dillon, Harwood-Nash, and Picard are included. This book covers the most recent advances in neuroradiology.
