This resource guides prescribers, pharmacists, and regulators with an update on the recent expansion of basic and clinical knowledge that forms a framework for understanding cutaneous reactions. This understanding will lead, in turn, to better outcomes and decisions in treatment and management, both in the clinic and in the life cycle of drug development. The skin is a common target for adverse drug events and even mild rashes can be part of life-threatening syndromes. Patients and practitioners often face important decisions about therapy after a drug eruption, including treatment, cross-reactivity with future pharmaceuticals, genetic considerations and dealing with long-term sequelae after a reaction. An international team of experts and leaders in the field share their story and insights into the scientific details and relevant clinical context.
An indispensable tool for understanding, diagnosing and managing this common clinical problem The skin is one of the most frequently involved organs in adverse drug reactions. Occurring with an incidence of 1-5% for certain types of drugs, cutaneous drug eruptions are mostly benign in nature, and comprise the maculopapular type of eruption and urticaria. However, about one third of them require hospital treatment, leading to a considerable burden for the health care system. In this book, a selected group of experts provide an up-to-date, condensed and clinically relevant overview of the field of cutaneous drug eruptions, ranging from epidemiology and genetic predisposition to available therapeutic measures, including rapid drug desensitization. Reflecting the great progress made in recent years in this field, this publication will be a useful tool for a better understanding, diagnosis and management of cutaneous drug eruptions, not only for general physicians, dermatologists and clinical allergologists, but also for nurses and scientists.
Adverse cutaneous drug reactions (ACDR) are among the most frequent events in patients receiving drug therapy. Cardiovascular (CV) drugs are an important group of drugs with potential risk of developing ACDR especially in elderly as marketing of more new drugs and their prescription continue to increase. However, like with most other drugs the exact incidence of cutaneous side effects from CV drugs is difficult to estimate due to sporadic reporting. Moreover, a reliable designation of a certain drug as the cause of a certain type of reaction can rarely be made. Apart from the well-known angioedema/urticaria from ACE inhibitors, lichen planus / lichenoid reaction from beta adrenergic blockers and photosensitivity from thiazid diuretics, ACDR from CV drugs might be seen in a wide spectrum extending to rare but life-threatening conditions such as erythroderma, Stevens-Johnson syndrome, toxic epidermal necrolysis or drug hypersensitivity syndrome. In this comprehensive review, the reported types of ACDR to CV drugs will be discussed according to drug class and the type of dermatologic reaction with special emphasize on cross-reactions and the role of patch testing in diagnosis.
The burden of cutaneous drug reactions is significant, in both outpatient and inpatient settings, and can result in morbidity and even mortality. This book is unique in its approach to this problem. This text is divided into basic principles, common drug reactions, skin conditions mimicked by drug reactions, drug reactions to the skin appendages, life-threatening drug reactions, less common drug reactions, and special groupings of drug reactions. For the clinician, the skin can only morphologically react in to many limited ways. This is also true for the pathologist. Combining these two forever linked specialties is a synergistic paradigm that greatly enhances diagnosis, and ultimately therapy, for these pernicious conditions. Drug reactions in the skin remain a common complication of therapy. True incidences of drug reactions are not available. For general discussion, the rule of 3% can be applied with reasonable assuredness. Approximately 3% of all hospitalized patients develop an adverse cutaneous drug reaction. Approximately 3% of these reactions are considered severe. Outpatient data is even more obscure, but at least 3% of dermatology clinic outpatient visits are due to a drug reaction. Cutaneous drug reactions compromise approximately 3% of all drug reactions. Even more challenging is the fact that the most vulnerable populations to drug reactions are increasing and include the elderly patients on prolonged drug therapy, and patients that use multiple drugs at the same time.
Internationally relied upon by medical practitioners for its unparalleled focus on adverse effects and cutaneous reactions, Litt’s Drug Eruption & Reaction Manual is a succinct clinical reference and essential drug-safety tool for patient care. This 27th edition is a comprehensively revised and updated quick reference, and each entry includes: * Quantitative summaries of reports and incidence for reactions * Drug–drug interactions * Categories of adverse drug reactions, eruptions, and cutaneous reaction patterns * Essential reference information on prescription and over-the-counter drugs as well as herbals and supplements The book contains... * A to Z listing of the 1500 most consulted drug and herbal profiles, including generic name and trade names; pharmaceutical company; indications; half-life; and pregnancy category * Over 31,000 adverse reactions and drug-eruption listings * Includes supplements, vaccines, and botanicals * Clinical definitions of common and severe adverse reactions * List of drugs that cause severe adverse reactions * List of main classes of drugs as a quick clinical reference guide * 27 tables of members of a class of drugs (such as statins or monoclonal antibodies), enabling clinicians to see at a glance whether a reaction is common to all drugs included in that class, or to a majority of them, or is known in only a handful—information that is critical for an informed decision to change drugs within the same class * 2 extensive tables showing reported genetic associations with cutaneous adverse drug reactions and recommendations regarding genetic screening to prevent cutaneous adverse drug reactions * A concordance of synonyms and trade names for ease of cross-reference Markets: Dermatologists, Neurologists, Oncologists, Psychiatrists, Pharmacists, Family Physicians, and those caring for patients on multiple medications, such as Geriatricians and Hospital Generalist Physicians. Litt’s Drug Eruption & Reaction Manual is a succinct clinical reference derived from Litt’s Drug Eruption & Reaction Database, located at www.drugeruptiondata.com, which currently holds over 1750 drug profiles with almost 70,000 documented drug reactions, as evidenced by well over 145,000 references on PubMed. Quick and easy access via the Litt app provides real time access to the most up-to-date drug safety information to a busy practitioner on-the-go. Subscribers to the database benefit from: * Easy access via the Litt app, ideal for working across a number of work-places * Full drug profiles with a wealth of information including category, half-life, indications, drug-drug interactions, and known adverse reactions * Links to PubMed abstracts * Searching a class of drugs for a specific reaction * Searching by adverse reaction pattern * Searching by indication for a drug * Searching by drug name (generic name/brand name) as well as by pharmaceutical company or drug class * Searching herbal medicines and supplements * Diagnosing the cause of reactions in patients on multiple drugs by selecting the adverse reaction(s) experienced and the drug(s) the patient is taking * Comparing reaction profiles for up to four drugs in a customized chart that can be saved for future reference * Descriptions of reaction patterns * Photographs of adverse reactions * Access via a computer, tablet, or smartphone * Regular updates To learn more, and to subscribe to the database, visit www.drugeruptiondata.com.
This book covers all aspects of hypersensitivity to drugs, providing practical information for non-specialist physicians as well as addressing issues of interest to practitioners in different specialties and presenting the expert knowledge required by specialist allergists and immunologists. The opening, general section discusses basics such as clinical manifestations, histopathology, mechanisms, risk factors, drug hypersensitivity in particular populations, and the full range of diagnostic methods. The second part of the book provides concise information on the most important drug classes and guides the reader on how to proceed when patients present with a suspected reaction. For each drug class, the current level of evidence for use of the different diagnostic tools, including skin tests, provocation tests, and in vitro tests, is clarified, and management options, outlined. The inclusion of helpful tables and algorithms is designed to aid in decision making. Drug hypersensitivity is among the more complex allergological issues, and this book will meet the needs of general practitioners, internists, and specialists.
The first book focusing specifically on frequent and frequently disabling side effects involving the skin, hair and nails in cancer patients According to the World Health Organization, there are approximately thirty million people living with a diagnosis of cancer – the majority of whom will receive surgery, systemic therapy, and/or radiation, and who will suffer from dermatologic adverse events. Dermatologists and oncologists are only beginning to grapple with these events, which pose serious quality-of-life issues with so many patients, and will become more prevalent as survival rates improve, thanks in part to new cancer treatments and drug regimens. Concentrating on a topic that has only been briefly touched upon by other texts, this book offers a focused perspective on the clinical presentation, underlying pathophysiologic mechanisms, and management of skin, hair, and nail conditions for oncologists, dermatologists, and allied practitioners. Dermatologic Principles and Practice in Oncology: Conditions of the Skin, Hair, and Nails in Cancer Patients: • Covers in detail the dermatologic adverse events of oncologic therapies, clinical presentations, and treatment recommendations • Enables dermatologists and other practitioners to significantly improve the care of patients with cancer • Addresses the dermatologic adverse events of cancer therapies used globally, of which a large number are found in developing countries • Emphasizes prophylactic measures – based on treatments used and type of cancer – to prevent the appearance of adverse events • Provides built-in discussions on patient education for practical counseling during therapies • Offers rapid-reference sections on topical dermatology drugs The first book to present dermatologic conditions in cancer patients and survivors in a uniform and in-depth manner, Dermatologic Principles and Practice in Oncology is ideal for oncologists, oncology nurses, and dermatologists who wish to take better care of those with adverse skin, hair, and nail conditions.
With a focus on improving diagnosis and treatment, Drug Allergy Testing is your new go-to resource for understanding various drug allergies and testing methods, the epidemiology of and economic impact of drug allergies, and new drug and allergy developments. Features a wealth of up-to-date information for allergists, immunologists, and primary care physicians who diagnose and treat patients with drug allergies and hypersensitivity. Covers the basics of drug allergy evaluation and management as well as specific drugs including antibiotics, ASA/NSAIDs, chemotherapeutic agents and monoclonal antibodies.
This book describes the relationship of the skin with cardiovascular disease. It details the variety of genetic, autoimmune, metabolic and endocrine factors that link the two disciplines. Recognition of one sign or symptom in dermatology can lead to the investigation and discovery of an important related cardiac condition, the recognition of which is important to prevent cardiovascular complications. Similarly, a cardiac condition may be related to an underlying skin condition that requires treatment. Genetic examples of such instances included within the book include: pseudoxanthoma elasticum, epidermolysis bullosa with desmosome defects and plectin defects; Marfan syndrome; Autoimmune conditions include vasculitis, sarcoidosis, lupus; metabolic conditions include insulin resistance, eruptive xanthomas with hypertriglyceridemias and elevated cholesterol; endocrine disorders include thyroid acropachy with atrial fibrillation; insulin resistance with coronary artery disease and psoriasis or hidradenitis suppurativa. Skin and the Heart reviews the effects of genetic, autoimmune and endocrine diseases with connections between skin and heart. It is therefore a key reference for all practitioners and researchers working in both disciplines.
