Depicts the first experiences of Hawaiian leader Kamehameha in battle, covering his overturning of the Naha Stone and other feats performed during his lifelong quest to unify the islands.
A leading cancer specialist tells the compelling stories of three adult leukemia patients, shedding new light on the disease itself and the drugs developed to treat it When you are told that you have leukemia, your world stops. Your brain can’t function. You are asked to make decisions about treatment almost immediately, when you are not in your right mind. And yet you pull yourself together and start asking questions. Beside you is your doctor, whose job it is to solve the awful puzzle of bone marrow gone wrong. The two of you are in it together. In When Blood Breaks Down, Mikkael Sekeres, a leading cancer specialist, takes readers on the journey that patient and doctor travel together. Sekeres, who writes regularly for the “Well” section of The New York Times, tells the compelling stories of three people who receive diagnoses of adult leukemia within hours of each other: Joan, a 48-year-old surgical nurse, a caregiver who becomes a patient; David, a 68-year-old former factory worker who bows to his family’s wishes and pursues the most aggressive treatment; and Sarah, a 36-year-old pregnant woman who must decide whether to undergo chemotherapy and put her fetus at risk. We join the intimate conversations between Sekeres and his patients, and we watch as he teaches trainees. Along the way, Sekeres also explores leukemia in its different forms and the development of drugs to treat it—describing, among many other fascinating details, the invention of the bone marrow transplant (first performed experimentally on beagles) and a treatment that targets the genetics of leukemia. The lessons to be learned from leukemia, Sekeres shows, are not merely medical; they teach us about courage and grace and defying the odds.
Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme
“The work of a young writer with tremendous ambition, a bildungsroman of religion and revolution set during an obscure chapter of American history.” —The Washington Post A powerful and impressive debut novel from the winner of the Tennessee Williams/New Orleans Literary Festival Prize for fiction—first in the Woolsack family saga that continues with Secessia and The New Inheritors. The Blood of Heaven is the story of Angel Woolsack, a preacher’s son, who flees the hardscrabble life of his itinerant father, falls in with a charismatic highwayman, then settles with his adopted brothers on the rough frontier of West Florida, where American settlers are carving their place out of lands held by the Spaniards and the French. The novel moves from the bordellos of Natchez, where Angel meets his love Red Kate to the Mississippi River plantations, where the brutal system of slave labor is creating fantastic wealth along with terrible suffering, and finally to the back rooms of New Orleans among schemers, dreamers, and would-be revolutionaries plotting to break away from the young United States and create a new country under the leadership of the renegade founding father Aaron Burr. The Blood of Heaven is a remarkable portrait of a young man seizing his place in a violent new world, a moving love story, and a vivid tale of ambition and political machinations that brilliantly captures the energy and wildness of a young America where anything was possible. It is a startling debut. “Wascom is a craftsman, and each of his lengthy, winding sentences shimmers with the tang of blood and bone and sweat, and the archaic splendor of his language.” —The Boston Globe
Break That Curse, Be Free Before you read the next sentence in this book, I want to make you realise that looking into the pages of this book has implicated you for one singular outcome, deliverance and freedom from all curses. The book is power-packed, full of the power of the Holy Spirit to break every curse that may be holding you down. Some of the challenges that some believers go through is not because the devil is too strong to keep them limited and bound to the place where they are at the moment. But the words, decrees, and curses issued against their lives have made them remain where they are. Claiming ignorance of a curse won't help you. Pretending that everything is okay won't solve the problem too. But taking definite action will deliver and make you free. The challenge is many people aren't even aware of the kind of action that they should take to break curses off their lives. You have nothing to worry about. That is why the Lord has inspired me to write this book for you so that you can know what to do to break any curse that is upon your life and destiny. In this book, you will: ★★Pray Prayers that will break curses off your life ★★Learn how to correctly apply the Blood of Jesus on Curses I know this is what you want, Click the Buy Now with One Click
"The most important book to read about the AI boom" (Wired): The "gripping" (New Yorker) true story of the first time machines came for human jobs—and how the Luddite uprising explains the power, threat, and toll of big tech and AI today Named one of the best books of the year by The New Yorker, Wired, and the Financial Times • A Next Big Idea Book Club "Must-Read" The most urgent story in modern tech begins not in Silicon Valley but two hundred years ago in rural England, when workers known as the Luddites rose up rather than starve at the hands of factory owners who were using automated machines to erase their livelihoods. The Luddites organized guerrilla raids to smash those machines—on punishment of death—and won the support of Lord Byron, enraged the Prince Regent, and inspired the birth of science fiction. This all-but-forgotten class struggle brought nineteenth-century England to its knees. Today, technology imperils millions of jobs, robots are crowding factory floors, and artificial intelligence will soon pervade every aspect of our economy. How will this change the way we live? And what can we do about it? The answers lie in Blood in the Machine. Brian Merchant intertwines a lucid examination of our current age with the story of the Luddites, showing how automation changed our world—and is shaping our future.
Welcome to the nightmare . . . There is a world you don't know about, inhabited by supernatural creatures of darkness—vampires, werewolves, and all manner of savage, impossible beasts that live for terror and slaughter and blood. They are all around us but you cannot see them, for knowledge of their presence—so close and so hungry—would surely drive any ordinary human insane. But for centuries a special breed of hunter has kept the monsters at bay, preventing them from breaking through the increasingly fragile barriers protecting our mortal realm. These guardians are called skinners. But beware . . . for there are very few of them left.