Written by pioneers in this exciting new field, Algebraic Statistics introduces the application of polynomial algebra to experimental design, discrete probability, and statistics. It begins with an introduction to Grobner bases and a thorough description of their applications to experimental design. A special chapter covers the binary case
Algebraic statistics uses tools from algebraic geometry, commutative algebra, combinatorics, and their computational sides to address problems in statistics and its applications. The starting point for this connection is the observation that many statistical models are semialgebraic sets. The algebra/statistics connection is now over twenty years old, and this book presents the first broad introductory treatment of the subject. Along with background material in probability, algebra, and statistics, this book covers a range of topics in algebraic statistics including algebraic exponential families, likelihood inference, Fisher's exact test, bounds on entries of contingency tables, design of experiments, identifiability of hidden variable models, phylogenetic models, and model selection. With numerous examples, references, and over 150 exercises, this book is suitable for both classroom use and independent study.
Written by experts in both mathematics and biology, Algebraic and Discrete Mathematical Methods for Modern Biology offers a bridge between math and biology, providing a framework for simulating, analyzing, predicting, and modulating the behavior of complex biological systems. Each chapter begins with a question from modern biology, followed by the description of certain mathematical methods and theory appropriate in the search of answers. Every topic provides a fast-track pathway through the problem by presenting the biological foundation, covering the relevant mathematical theory, and highlighting connections between them. Many of the projects and exercises embedded in each chapter utilize specialized software, providing students with much-needed familiarity and experience with computing applications, critical components of the "modern biology" skill set. This book is appropriate for mathematics courses such as finite mathematics, discrete structures, linear algebra, abstract/modern algebra, graph theory, probability, bioinformatics, statistics, biostatistics, and modeling, as well as for biology courses such as genetics, cell and molecular biology, biochemistry, ecology, and evolution. Examines significant questions in modern biology and their mathematical treatments Presents important mathematical concepts and tools in the context of essential biology Features material of interest to students in both mathematics and biology Presents chapters in modular format so coverage need not follow the Table of Contents Introduces projects appropriate for undergraduate research Utilizes freely accessible software for visualization, simulation, and analysis in modern biology Requires no calculus as a prerequisite Provides a complete Solutions Manual Features a companion website with supplementary resources
Algebraic statistics uses tools from algebraic geometry, commutative algebra, combinatorics, and their computational sides to address problems in statistics and its applications. The starting point for this connection is the observation that many statistical models are semialgebraic sets. The algebra/statistics connection is now over twenty years old, and this book presents the first broad introductory treatment of the subject. Along with background material in probability, algebra, and statistics, this book covers a range of topics in algebraic statistics including algebraic exponential families, likelihood inference, Fisher's exact test, bounds on entries of contingency tables, design of experiments, identifiability of hidden variable models, phylogenetic models, and model selection. With numerous examples, references, and over 150 exercises, this book is suitable for both classroom use and independent study.
Algebraic statistics brings together ideas from algebraic geometry, commutative algebra, and combinatorics to address problems in statistics and its applications. Computer algebra provides powerful tools for the study of algorithms and software. However, these tools are rarely prepared to address statistical challenges and therefore new algebraic results need often be developed. This way of interplay between algebra and statistics fertilizes both disciplines. Algebraic statistics is a relatively new branch of mathematics that developed and changed rapidly over the last ten years. The seminal work in this field was the paper of Diaconis and Sturmfels (1998) introducing the notion of Markov bases for toric statistical models and showing the connection to commutative algebra. Later on, the connection between algebra and statistics spread to a number of different areas including parametric inference, phylogenetic invariants, and algebraic tools for maximum likelihood estimation. These connection were highlighted in the celebrated book Algebraic Statistics for Computational Biology of Pachter and Sturmfels (2005) and subsequent publications. In this report, statistical models for discrete data are viewed as solutions of systems of polynomial equations. This allows to treat statistical models for sequence alignment, hidden Markov models, and phylogenetic tree models. These models are connected in the sense that if they are interpreted in the tropical algebra, the famous dynamic programming algorithms (Needleman-Wunsch, Viterbi, and Felsenstein) occur in a natural manner. More generally, if the models are interpreted in a higher dimensional analogue of the tropical algebra, the polytope algebra, parametric versions of these dynamic programming algorithms can be established. Markov bases allow to sample data in a given fibre using Markov chain Monte Carlo algorithms. In this way, Markov bases provide a means to increase the sample size and make statistical tests in inferential statistics more reliable. We will calculate Markov bases using Groebner bases in commutative polynomial rings. The manuscript grew out of lectures on algebraic statistics held for Master students of Computer Science at the Hamburg University of Technology. It appears that the first lecture held in the summer term 2008 was the first course of this kind in Germany. The current manuscript is the basis of a four-hour introductory course. The use of computer algebra systems is at the heart of the course. Maple is employed for symbolic computations, Singular for algebraic computations, and R for statistical computations. The second edition at hand is just a streamlined version of the first one.$cen$dAbstract
Mathematics of Bioinformatics: Theory, Methods, and Applications provides a comprehensive format for connecting and integrating information derived from mathematical methods and applying it to the understanding of biological sequences, structures, and networks. Each chapter is divided into a number of sections based on the bioinformatics topics and related mathematical theory and methods. Each topic of the section is comprised of the following three parts: an introduction to the biological problems in bioinformatics; a presentation of relevant topics of mathematical theory and methods to the bioinformatics problems introduced in the first part; an integrative overview that draws the connections and interfaces between bioinformatics problems/issues and mathematical theory/methods/applications.
This text presents mathematical biology as a field with a unity of its own, rather than only the intrusion of one science into another. The book focuses on problems of contemporary interest, such as cancer, genetics, and the rapidly growing field of genomics.
How does an algebraic geometer studying secant varieties further the understanding of hypothesis tests in statistics? Why would a statistician working on factor analysis raise open problems about determinantal varieties? Connections of this type are at the heart of the new field of "algebraic statistics". In this field, mathematicians and statisticians come together to solve statistical inference problems using concepts from algebraic geometry as well as related computational and combinatorial techniques. The goal of these lectures is to introduce newcomers from the different camps to algebraic statistics. The introduction will be centered around the following three observations: many important statistical models correspond to algebraic or semi-algebraic sets of parameters; the geometry of these parameter spaces determines the behaviour of widely used statistical inference procedures; computational algebraic geometry can be used to study parameter spaces and other features of statistical models.