Leukotrienes as Mediators of Asthma and Inflammation
Leukotrienes as Mediators of Asthma and Inflammation

Author: Sven-Erik Dahlén

Publisher: Lippincott Williams & Wilkins

Published: 1994

Total Pages: 384

ISBN-13: 9780781702478

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This volume presents the work of distinguished investigators who have conducted major studies on the role of eicosanoids in inflammation. The book provides an informative appraisal of the current state of the art in leukotriene and inflammation research, integrating new basic science concepts and clinical findings. The primary focus of the book is on the evidence that leukotrienes represent a group of mediators that contribute significantly to the pathobiology of asthma and play a role in other inflammatory disorders. The information presented in this volume is of vital importance to pharmacologists, biochemists, and physiologists, as well as to clinicians treating patients with asthma and other inflammatory diseases.

Severe Asthma
Severe Asthma

Author: Kian Fan Chung

Publisher: European Respiratory Society

Published: 2019-06-01

Total Pages: 365

ISBN-13: 1849841047

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Severe asthma is a form of asthma that responds poorly to currently available medication, and its patients represent those with greatest unmet needs. In the last 10 years, substantial progress has been made in terms of understanding some of the mechanisms that drive severe asthma; there have also been concomitant advances in the recognition of specific molecular phenotypes. This ERS Monograph covers all aspects of severe asthma – epidemiology, diagnosis, mechanisms, treatment and management – but has a particular focus on recent understanding of mechanistic heterogeneity based on an analytic approach using various ‘omics platforms applied to clinically well-defined asthma cohorts. How these advances have led to improved management targets is also emphasised. This book brings together the clinical and scientific expertise of those from around the world who are collaborating to solve the problem of severe asthma.

Itch
Itch

Author: E. Carstens

Publisher: CRC Press

Published: 2014-02-25

Total Pages: 482

ISBN-13: 1466505435

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Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.

Basic & Clinical Pharmacology
Basic & Clinical Pharmacology

Author: Bertram G. Katzung

Publisher: McGraw-Hill/Appleton & Lange

Published: 1998

Total Pages: 1176

ISBN-13: 9780838505656

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This edition contains new material on receptors, including their molecular biology, and updated information on central nervous system drugs, including new drugs released through to July 1996.

The Eicosanoids
The Eicosanoids

Author: Peter Curtis-Prior

Publisher: John Wiley & Sons

Published: 2004-07-16

Total Pages: 654

ISBN-13: 047002061X

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This comprehensive reference work, updated from the first edition, brings together the knowledge and expertise of contributors from around the world. It includes new topics such as prostaglandin synthetase enzyme, new synthetic eicosanoids, innovative analytical methods, the influence of cytokines in the regulation of synthesis and actions, newer eicosanoids that influence the cardiovascular system, and newly discovered roles in reproduction and interactions with nitric oxide. This book satisfies a surge of interest in prostaglandins—NSAIDS (e.g. aspirin) are the biggest selling drugs of all time, and the field has been refreshed by the advent of new types (selective COX-2 inhibitors, anti-leukotiene drugs).

Microcirculation
Microcirculation

Author: Ronald F. Tuma

Publisher: Academic Press

Published: 2011-04-28

Total Pages: 999

ISBN-13: 0080569935

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This reference is a volume in the Handbook of Physiology, co-published with The American Physiological Society. Growth in knowledge about the microcirculation has been explosive with the field becoming fragmented into numerous subdisciplines and subspecialties. This volume pulls all of the critical information into one volume. - Meticulously edited and reviewed. Benefit: Provides investigators a unique tool to explore the significance of their findings in the context of other aspects of the microcirculation. In this way, the updated edition has a direct role in helping to develop new pathways of research and scholarship - Highlights the explosive growth in knowledge about the microcirculation including the biology of nitric oxide synthase (NOS), endothelial cell signaling, angiogenesis, cell adhesion molecules, lymphocyte trafficking, ion channels and receptors, and propagated vasomotor responses. Benefit: Microcirculatory biology has become fragmented into numerous sub-disciplines and subspecialties, and these reference reintegrates the information in one volume