Drug-Induced Liver Injury
Drug-Induced Liver Injury

Author:

Publisher: Academic Press

Published: 2019-07-13

Total Pages: 290

ISBN-13: 0128173173

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Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series

Rheumatoid Arthritis
Rheumatoid Arthritis

Author: John J. Cush

Publisher:

Published: 2008-01-01

Total Pages: 368

ISBN-13: 1932610286

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Emphasizes the importance of early intervention in RA with focus on pharmacologic treatment of RA. Detailed information on the various medications employed in treatment, including corticosteroids, NSAIDs DMARDs, biologic agents, and combination therapy is reviewed, including evidence based data on efficacy, safety, side effects, and monitoring requirements. Clinical evaluation is presented, including lab findings, joint scoring, diagnostic criteria, and radiographic outcomes. Surgical options and the management of advanced RA are disussed.

Early Rheumatoid Arthritis
Early Rheumatoid Arthritis

Author: Paul Emery

Publisher:

Published: 2005

Total Pages: 0

ISBN-13: 9781416027676

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This issue covers the latest developments in the understanding of rheumatoid arthritis at the early stage. Treatments such as with newer biologic agents and conventional disease-modifying antirheumatic drugs are reviewed. Also included are articles on imaging modalities as a means of identifying those in the early stages and monitoring response to treatment.

The Sclera
The Sclera

Author: Maite Sainz de la Maza

Publisher: Springer Science & Business Media

Published: 2012-02-15

Total Pages: 331

ISBN-13: 1441965017

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The Sclera is the definitive text on the diagnosis and treatment of scleral diseases, with in-depth chapters on non-infectious scleritis, infectious sclertitis, non-inflammatory diseases of the sclera, and systemic implications of scleral disease. Basic physiology, anatomy, and biochemistry are addressed as well. Written for the ophthalmologist, the revised and updated new edition of The Sclera contains the most current information available on newer characterizations of the composition of the sclera, immune derangements of it, and success in medical and surgical treatment of the inflammatory diseases of the sclera.

Quantitative Pharmacology and Individualized Therapy Strategies in Development of Therapeutic Proteins for Immune-Mediated Inflammatory Diseases
Quantitative Pharmacology and Individualized Therapy Strategies in Development of Therapeutic Proteins for Immune-Mediated Inflammatory Diseases

Author: Honghui Zhou

Publisher: John Wiley & Sons

Published: 2019-02-14

Total Pages: 518

ISBN-13: 111928922X

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Thorough Overview Identifies and Addresses Critical Gaps in the Treatment of Several Chronic Diseases With increasing numbers of patients suffering from Immune-Mediated Inflammatory Diseases (IMIDs), and with the increasing reliance on biopharmaceuticals to treat them, it is imperative that researchers and medical practitioners have a thorough understanding of the absorption, distribution, metabolism and excretion (ADME) of therapeutic proteins as well as translational pharmacokinetic/pharmacodynamic (PK/PD) modeling for them. This comprehensive volume answers that need to be addressed. Featuring eighteen chapters from world-renowned experts and opinion leaders in pharmacology, translational medicine and immunology, editors Honghui Zhou and Diane Mould have curated a much-needed collection of research on the advanced applications of pharmacometrics and systems pharmacology to the development of biotherapeutics and individualized treatment strategies for the treatment of IMIDs. Authors discuss the pathophysiology of autoimmune diseases in addition to both theoretical and practical aspects of quantitative pharmacology for therapeutic proteins, current translational medicine research methodologies and novel thinking in treatment paradigm strategies for IMIDs. Other notable features include: • Contributions from well-known authors representing leading academic research centers, specialized contract research organizations and pharmaceutical industries whose pipelines include therapeutic proteins • Chapters on a wide range of topics (e.g., pathophysiology of autoimmune diseases, biomarkers in ulcerative colitis, model-based meta-analysis use in the development of therapeutic proteins) • Case studies of applying quantitative pharmacology approaches to guiding therapeutic protein drug development in IMIDs such as psoriasis, inflammatory bowel disease, multiple sclerosis and lupus Zhou and Mould’s timely contribution to the critical study of biopharmaceuticals is a valuable resource for any academic and industry researcher working in pharmacokinetics, pharmacology, biochemistry, or biotechnology as well as the many clinicians seeking the safest and most effective treatments for patients dealing with chronic immune disorders.

Next-Generation Therapies and Technologies for Immune-Mediated Inflammatory Diseases
Next-Generation Therapies and Technologies for Immune-Mediated Inflammatory Diseases

Author: Paola Mina-Osorio

Publisher: Springer

Published: 2017-01-21

Total Pages: 206

ISBN-13: 3319422529

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As our understanding of immune mediated chronic inflammatory diseases (IMIDs) grows, it becomes more and more clear that these conditions result from the convergence of a multitude of pathogenic mechanisms whose relative individual contribution is different in different patient subsets. Promising new technologies have been conceived that address the hypotheses that targeting multiple pathways simultaneously, selectively delivering therapeutics to areas of inflammation and/or resetting the immune system, could take efficacy to new levels. However, we have long waited for the arrival of some of these technologies to the bedside, or even far enough in the drug development process in spite of the initial enthusiasm. Some of the examples covered in this book include bispecific antibodies and genomic medicines, microparticles and targeted delivery of drugs to inflamed vasculature. Most published reviews and book chapters on novel therapies for inflammatory diseases describe positive attributes of molecules or technologies under investigation and the rationale for developing them into therapeutics. The originality and potential value of this book is not in the description of these targets or technologies from the point of view of their structure or mechanism of action exclusively, but rather, in making an effort to critically address the question of what is needed to move these technologies into the clinic. Has the technology not made it past the preclinical stage and why? Has it already been tested in humans and failed? What are the potential reasons behind those failures? What do experts in each field believe can be done better to increase the probabilities of success? In addition, the authors address the competitive landscape and summarize clinical studies that have failed in the respective area. They talk about the patient populations that would be required for the successful conduction of a clinical trial to test certain molecules, and they proactively share their views regarding both the potential and the drawbacks of targets or methodologies.

Inflammatory Arthritis in Clinical Practice
Inflammatory Arthritis in Clinical Practice

Author: Ian C. Scott

Publisher: Springer

Published: 2015-02-07

Total Pages: 226

ISBN-13: 1447166485

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Understanding the key components of the diagnosis, assessment and management of inflammatory arthritis patients is essential to improving patient care. This book aims to cover these areas. It places inflammatory arthritis into a historical context; deals with the epidemiology, pathology, clinical assessment and investigation of inflammatory arthritis patients and provides a comprehensive overview of currently available treatment options. It provides insight into stratified medicine, an area of emerging importance in the management of heterogeneous diseases like RA. Finally, it provides an overview of what treatments strategies are in development.

An Index of Treatment by Various Writers (Classic Reprint)
An Index of Treatment by Various Writers (Classic Reprint)

Author: Robert Hutchison

Publisher: Forgotten Books

Published: 2017-10-27

Total Pages: 1042

ISBN-13: 9780266785538

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Excerpt from An Index of Treatment by Various Writers And first, before beginning treatment, it is essential to have a plan, for plan less, indeterminate measures are not likely to be successful. The plan should be founded upon the indications for treatment - that is to say, with a view to the objects to be achieved, whether these be the cure of the disease or the mere alleviation of symptoms. It is well to remember, in this connection, the limitations of treatment, and not to attempt the impossible. One must always take care also to cut one's therapeutic coat according to one's cloth, and not to embark upon a plan of treat ment which the patient's circumstances or means will not enable him to carry out. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.

ABC of Rheumatology
ABC of Rheumatology

Author: Ade Adebajo

Publisher: John Wiley & Sons

Published: 2018-06-18

Total Pages: 226

ISBN-13: 1118793218

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ABC of Rheumatology continues to be a practical and informative guide to the assessment, treatment and management of common rheumatic and musculoskeletal conditions within primary care. Fully updated to reflect developments in this fast growing field, the fifth edition covers overviews of all key areas of rheumatology, and includes new chapters on radiology and immunology, as well as expanded coverage on metabolic bone disease, chronic widespread pain, and complex regional pain syndrome. Featuring highly illustrated chapters, boxed summaries and links to further resources, ABC of Rheumatology is an accessible reference for all primary care health professional, general practitioners, family physicians, junior doctors, medical students and nurses.