Understanding Molecular Mechanisms of Breast Cancer Metastasis Using Genetically-engineered Mice
Author: Leah Marie Cook
Publisher:
Published: 2011
Total Pages: 150
ISBN-13:
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Author: Leah Marie Cook
Publisher:
Published: 2011
Total Pages: 150
ISBN-13:
DOWNLOAD EBOOKAuthor: Bruce Alberts
Publisher:
Published: 2002
Total Pages: 0
ISBN-13: 9780815332183
DOWNLOAD EBOOKAuthor: Eric C. Holland
Publisher: John Wiley & Sons
Published: 2004-08-27
Total Pages: 504
ISBN-13: 047144460X
DOWNLOAD EBOOKMice have become the species of choice for modeling the complex interactions between tumor cells and the host environment. Mouse genetics are easily manipulated, and a growing array of technology exists for this purpose. Mouse models allow investigators to better understand causal relationships between specific genetic alterations and tumors, utilize new imaging techniques, and test novel therapies. Recent developments along these lines show great promise for the development of new anti-cancer treatments. Mouse Models of Human Cancer provides researchers and students with a complete resource on the subject, systematically presenting the principles, methodologies, applications, and challenges associated with this exciting field. Offering a survey of the latest research and a description of future areas of interest, this text: Presents real experimental data Describes organ site-specific mouse models Clearly identifies suitable models for further drug testing Critically analyzes current methodologies and their limitations Features numerous recognizable expert contributors Lists key Web sites, reagents, and companies From mouse handling and genetic engineering to preclinical trials, Mouse Models of Human Cancer is a comprehensive guide to using these models and relating them to human disease. Its uniform presentation describes organ-specific models in clinical, imaging, and molecular terms, and lays out the relevant genetics, experimental approaches, histological comparisons with human disease, and conclusions. Combining stellar chapter authors, rich illustrations, and clear, up-to-date coverage, Mouse Models of Human Cancer is an invaluable resource for advanced students and cutting-edge researchers.
Author:
Publisher:
Published: 19??
Total Pages:
ISBN-13:
DOWNLOAD EBOOKMaterial in the Australian performing arts programs and ephemera (PROMPT) collection consists of programs and related items for Australian performing arts organisations, Australian artists performing overseas, professional productions performed in Australia (including those featuring overseas performers) and overseas performances of Australian plays, music, etc.
Author: Jeffrey E. Green
Publisher: Springer Science & Business Media
Published: 2011-12-09
Total Pages: 639
ISBN-13: 0387698051
DOWNLOAD EBOOKGenetically-engineered mouse models for cancer research have become invaluable tools for studying cancer biology and evaluating novel therapeutic approaches. This volume focuses on state-of-the-art methods for generating, analyzing and validating such models for studying aspects of human cancer biology. Additionally, these models are emerging as important pre-clinical systems in which to test cancer prevention and therapeutic strategies in order to select compounds for testing in clinical trials.
Author: Christoph B. Wyss
Publisher:
Published: 2016
Total Pages: 165
ISBN-13:
DOWNLOAD EBOOKAuthor: Robert Eferl
Publisher: Humana Press
Published: 2015-01-31
Total Pages: 463
ISBN-13: 9781493922987
DOWNLOAD EBOOKThis volume is essential for geneticists, molecular biologists, biochemists, and medical doctors interested in the use of mouse models in cancer research. Recent genome studies, together with refined genetic engineering techniques, have greatly increased the value of using mice for research on cancer and other human disorders. The chapters of this book will support scientists in choosing the most suitable mouse models for their research questions. The book provides detailed methodological information for genetic or chemical induction of different types of cancer, histomorphometric cancer analysis, and in vivo imaging, as well as protocols to investigate oncogene addiction, immune surveillance, and hallmarks of cancer such as angiogenesis or metastasis. Four review-like articles provide background information on mouse technologies and histopathologic differences between mouse and human cancers. The mouse models described in individual chapters will fuel the understanding of cancer initiation, immune system roles, tumor angiogenesis, invasion, metastasis, and the relevance of molecular diversity observed among human cancers. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and resourceful, Mouse Models of Cancers: Methods and Protocols, is a valuable laboratory resource for all researchers, from the graduate level upwards, who study cancer and new possibilities for its treatment.
Author: Sam Thiagalingam
Publisher: Cambridge University Press
Published: 2015-04-09
Total Pages: 597
ISBN-13: 0521493390
DOWNLOAD EBOOKAn overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.
Author:
Publisher:
Published: 2003
Total Pages: 19
ISBN-13:
DOWNLOAD EBOOKClusterin is a multifunctional glycoproptein involved in tissue remodeling and apoptosis. However, recent studies have demonstrated that clusterin expression correlates with tumor grade in prostate cancer and in one retrospective study has been associated with tumor progression in breast cancer. Furthermore clusterin expression has been correlated with resistance to cytotoxic compounds such as TNF-alpha in prostate cancer, suggesting that clusterin may play a role in surviving cells. In our studies, we have focused on determining whether clusterin plays a causative role in the progression of human breast cancer by promoting cell survival, increasing cell motility and resistance to cytotoxic drugs. Our studies have utilized an ER-alpha positive non-invasive MCF-7 cell line, an MCF-7 cell line genetically engineered to overexpress clusterin(MCF-7CLU) and an ER-alpha negative breast negative invasive SUM-159PT cell line. Our major finding to date are that MCF-7CLU cells express 5-10 fold higher levels of intra- and extra-cellular clusterin as compared to parental MCF-7 cells. The MCF-7CLU cell line exhibits increased growth rates, altered cellular morphology, a dramatic increase (10-fold) in invasive potential and a delayed apoptotic response to cytotoxic compounds such as TNF-alpha and Tamoxifen in comparison to the parental MCF-7 cells.
Author: Sylwia Henryka Gawrzak
Publisher:
Published: 2016
Total Pages: 136
ISBN-13:
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