Juvenile Huntington's Disease
Juvenile Huntington's Disease

Author: Oliver Quarrell

Publisher: Oxford University Press, USA

Published: 2009-01-08

Total Pages: 222

ISBN-13: 0199236127

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Huntington's disease (HD) is an inherited progressive neurodegenerative disorder. Although onset of HD usually occurs in adulthood, a small percentage of cases develop symptoms before 20 years of age (juvenile-onset Huntington's Disease or JHD). This book summarises, for the first time, the clinical and scientific knowledge available on JHD.

The Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy
The Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy

Author: Udo Rüb

Publisher: Springer

Published: 2015-09-29

Total Pages: 154

ISBN-13: 331919285X

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This monograph describes the progress in neuropathological HD research made during the last century, the neuropathological hallmarks of HD and their pathogenic relevance. Starting with the initial descriptions of the progressive degeneration of the striatum as one of the key events in HD, the worldwide practiced Vonsattel HD grading system of striatal neurodegeneration will be outlined. Correlating neuropathological data with results on the functional neuroanatomy of the human brain, subsequent chapters will highlight recent HD findings: the neuronal loss in the cerebral neo-and allocortex, the neurodegeneration of select thalamic nuclei, the affection of the cerebellar cortex and nuclei, the involvement of select brainstem nuclei, as well as the pathophysiological relevance of these pathologies for the clinical picture of HD. Finally, the potential pathophysiological role of neuronal huntingtin aggregations and the most important and enduring challenges of neuropathological HD research are discussed.

Learning to Live with Huntington's Disease
Learning to Live with Huntington's Disease

Author: Sandy Sulaiman

Publisher: Jessica Kingsley Publishers

Published: 2007

Total Pages: 178

ISBN-13: 1843104873

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Huntington's Disease (HD), is a hereditary illness passed on via a defective gene. This book offers one family's poignant story of coping with the symptoms, the diagnosis and the effects of HD. It also presents the struggles and strengths of the whole family when one member loses their future to a terminal illness.

Caregiver's Handbook
Caregiver's Handbook

Author: DK

Publisher: Penguin

Published: 2013-09-01

Total Pages: 226

ISBN-13: 1465417443

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The Caregiver's Handbook is a definitive guide to caring for a sick or disabled person of any age. Whether it be adults looking after parents, partners looking after each other, parents looking after children, or young caregivers looking after their parents, the Caregiver's Handbook addresses both the needs of the caregiver, and person who needs care. The Caregiver's Handbook offers emotional support and practical advice on a wide range of topics, enabling individuals to provide the best care possible-whatever the requirements. Everyday concerns, including healthy eating, personal care, and rest and sleep, are addressed alongside topics such as safe movement and handling, choosing the right stability aids, or even how to maneuver a wheelchair for the first time. Features also include a look at how either at the needs of the caregiver, or how the requirement of specific conditions-such as dementia or physical impairment-can affect the way a task can be approached. The Caregiver's Handbook is a comprehensive, compassionate, and indispensable resource that all caregivers will want to have on hand at all times - it is essential reading for anyone caring for someone at home.

Behavioral Neurobiology of Huntington's Disease and Parkinson's Disease
Behavioral Neurobiology of Huntington's Disease and Parkinson's Disease

Author: Hoa Huu Phuc Nguyen

Publisher: Springer

Published: 2015-05-23

Total Pages: 402

ISBN-13: 366246344X

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Motor dysfunction and cognitive impairment are major symptoms in both Huntington’s Disease (HD) and Parkinson’s Disease (PD). A breakthrough in HD research was the identification of the gene that causes this devastating monogenetic illness. Similarly, several genes were found to cause familial forms of PD. With their identification, a plethora of genetic animal models has been generated and has revolutionized the understanding of the pathobiology and pathophysiology of these disorders. The models allow us to study the earliest manifestations of the diseases behaviorally and neuropathologically and help us understand how they progress over time. Additionally, neurotoxic animal models are still of high interest to the PD field, as they are being used to study e.g. mitochondrial dysfunction in PD. This book focuses on animal models of both diseases and how they have helped and will continue to help understand the behavioral neurobiology in these disorders.