This book provides the first presentation of the state-of-the-art in the application of modern Neuroscience research in predicting, preventing and alleviating the negative sequelae of neurodevelopmental, acquired, or neurodegenerative brain abnormalities on speech and language. To this end, this edited volume brings together contributions from several leading experts in a markedly broad range of disciplines, comprising Neurology, Neurosurgery, Genetics, Engineering, Neuroimaging and Neurostimulation, Neuropsychology, and Speech and Language Therapy.
Translational neuroscience is at the heart of clinical advancement in the fields of psychiatry, neurology and neurodevelopmental disorders. Written and edited by leading scientists and clinicians, this is a comprehensive and authoritative analysis of this emerging strategy for developing more effective treatments for brain disorders. Introductory chapters bring together perspectives from both academia and industry, while subsequent sections focus on disease groups, including bipolar disorder and depression, attention deficit hyperactivity disorder, substance abuse, autism, Alzheimer's disease, pain, epilepsy, Parkinson's disease and multiple sclerosis. Each section includes topical introductory and summary chapters, providing an overview and synthesis of the field. Translational Neuroscience: Applications in Psychiatry, Neurology, and Neurodevelopmental Disorders is an important text for clinicians, scientists and students in academic settings, government agencies and industry, as well as those working in the fields of public health and the behavioural sciences.
Conn's Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain,' with the results providing insight into the underlying basis of many neurological disease processes. This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis. In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn's Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance. - Provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, while also clearly demonstrating their emerging diagnostic and therapeutic importance - Features contributions from leading global basic and clinical investigators in the field - Provides a great resource for researchers and practitioners interested in the basic science underlying neurological processes - Relates and translates the current science to the understanding of neurological disorders and their treatment
Learning disabilities are a heterogeneous group of disorders characterized by failure to acquire, retrieve, and use information competently. These disorders have a multifactorial aetiology and are most common and severe in children, especially when comorbid with other chronic health conditions. This book provides current and comprehensive information about learning disorders, including information on neurobiology, assessment, clinical features, and treatment. Chapters cover such topics as historical research and hypotheses of learning disorders, neuropsychological assessment and counselling, characteristics of specific disorders such as autism and ADHD, evidence-based treatment strategies and assistive technologies, and much more.
Experts from academia and industry discuss how to create a new, more effective translational neuroscience drawing on novel technology and recent discoveries. Today, translational neuroscience faces significant challenges. Available therapies to treat brain and nervous system disorders are extremely limited and dated, and further development has effectively ceased. Disinvestment by the private sector occurred just as promising new technologies in genomics, stem cell biology, and neuroscience emerged to offer new possibilities. In this volume, experts from both academia and industry discuss how novel technologies and reworked translation concepts can create a more effective translational neuroscience. The contributors consider such topics as using genomics and neuroscience for better diagnostics and biomarker identification; new approaches to disease based on stem cell technology and more careful use of animal models; and greater attention to human biology and what it will take to make new therapies available for clinical use. They conclude with a conceptual roadmap for an effective and credible translational neuroscience—one informed by a disease-focused knowledge base and clinical experience. Contributors Tobias M. Böckers, Thomas Bourgeron, Karl Broich, Nils Brose, Bruce N. Cuthbert, Ilka Diester, Gül Dölen, Guoping Feng, Richard Frackowiak, Raquel E. Gur, Stephan Heckers, Franz Hefti, David M. Holtzman, Steven E. Hyman, Nancy Ip, Cynthia Joyce, Tobias Kaiser, Edward H. Koo, Walter J. Koroshetz, Katja S. Kroker, Robert C. Malenka, Isabelle Mansuy, Eliezer, Masliah, Yuan Mei, Andreas Meyer-Lindenberg, Lennart Mucke, Pierluigi Nicotera, Karoly Nikolich, Michael J. Owen, Menelas N. Pangalos, Alvaro Pascual-Leone, Joel S. Perlmutter, Trevor W. Robbins, Lee L. Rubin, Akira Sawa, Mareike Schnaars, Bernd Sommer, Maria Grazia Spillantini, Laura Spinney, Matthew W. State, Marius Wernig
Basic research over the last decade or two has uncovered similarities between speech, especially its sensori-motor aspects, and vocal communication in several non-human species. The most comprehensive studies so far have been conducted in songbirds. Songbirds offer us a model system to study the interactions between developmental or genetic predispositions and tutor-dependent influences, on the learning of vocal communication. Songbird research has elucidated cellular and molecular mechanisms underlying learning and production of vocal patterns, perception of vocal sounds, vocal motor control and vocal neuromotor plasticity. More recently, the entire genome of the songbird zebra finch has been sequenced. These discoveries, along with the identification of several genes implicated in familial human speech and language disorders, have made it possible to look for analogues of speech and language dysfunction in zebra finches, at least at the perceptual and sensori-motor levels. Two approaches in particular have led us closer to the development of animal models of human speech conditions, namely developmental stuttering and a familial verbal dyspraxia associated with a mutation in the gene for the transcription factor FoxP2. Work on other animals that show developmental sensori-motor learning of vocal sounds used for communication have also shown significant progress, leading to the possibility of development of models of speech and language dysfunction in them. Among mammals, the principal ones include dolphins and whales. In non-human primates, while vocal learning per se is not very prominent, investigations on their communicative abilities have thrown some light on the rudiments of language. These considerations make the publication of a book focused on animal models of speech and language disorders, detailing the overall investigative approach of neurobehavioral studies in animals capable of vocal communication and learned vocalizations, a much-needed and worthwhile project. It would serve as a unifying review of research in this new multidisciplinary frontier, spanning the molecular to the behavioral, for clinicians and researchers, as well as a teaching resource for advanced speech pathology and neuroscience students. This book will also be the first of its kind.
Interdisciplinary essays on music psychology that integrate scientific, humanistic, and artistic ways of knowing in transformative ways. Researchers using scientific methods and approaches to advance our understanding of music and musicality have not yet grappled with some of the perils that humanistic fields concentrating on music have long articulated. In this edited volume, established and emerging researchers—neuroscientists and cognitive scientists, musicians, historical musicologists, and ethnomusicologists—build bridges between humanistic and scientific approaches to music studies, particularly music psychology. Deftly edited by Elizabeth H. Margulis, Psyche Loui, and Deirdre Loughridge, The Science-Music Borderlands embodies how sustained interaction among disciplines can lead to a richer understanding of musical life. The essays in this volume provide the scientific study of music with its first major reckoning, exploring the intellectual history of the field and its central debates, while charting a path forward. The Science-Music Borderlands is essential reading for music scholars from any disciplinary background. It will also interest those working at the intersection of music and science, such as music teachers, performers, composers, and music therapists. Contributors: Manuel Anglada-Tort, Salwa El-Sawan Castelo-Branco, Hu Chuan-Peng, Laura K. Cirelli, Alexander W. Cowan, Jonathan De Souza, Diana Deutsch, Diandra Duengen, Sarah Faber, Steven Feld, Shinya Fujii, Assal Habibi, Erin. E. Hannon, Shantala Hegde, Beatriz Ilari, Jason Jabbour, Nori Jacoby, Haley E. Kragness, Grace Leslie, Casey Lew-Williams, Deirdre Loughridge, Psyche Loui, Diana Mangalagiu, Elizabeth H. Margulis, Randy McIntosh, Rita McNamara, Eduardo Reck Miranda, Daniel Müllensiefen, Rachel Mundy, Florence Ewomazino Nweke, Patricia Opondo, Aniruddh D. Patel, Andrea Ravignani, Carmel Raz, Matthew Sachs, Marianne Sarfati, Patrick E. Savage, Huib Schippers, Jim Sykes, Gary Tomlinson, Jamal Williams, Maria A. G. Witek, Pamela Z
This case series book offers a practical and accessible approach to psychiatry, addressing major clinical problems ranging from psychosis to aging effects, each of which is tackled as it arises in everyday settings. With its emphasis on everyday practice strongly linked to underlying theory, the book combines clinical knowledge with the realities of managing clinical problems, and will provide a basis for developing sound analytical and confident decision-making skills. Presenting different visions of clinical psychiatry and expanding psychiatrists’ interventions by integrating innovative neuroscience approaches such as neuroimaging, neuropsychology, TMS and cognitive rehabilitation, it will help clinicians and students alike gain a sound understanding of the wide range of signs and symptoms that indicate psychiatric disorders, and how the diagnosis, management and treatment options can differ from those in other medical specialties. The volume includes learning activities, with questions on each clinical case followed by detailed explanatory answers, and self-assessment exercises to assist with learning and revision. Throughout the book, tips and key features are highlighted with boxes, algorithms, tables and figures, which the reader can refer back to for exam revision and well into her/his career.
The Handbook of Adult Language Disorders is the essential guide to the scientific and clinical tenets of aphasia study and treatment. It focuses on how language breaks down after focal brain damage, what patterns of impairment reveal about normal language, and how recovery can be optimally facilitated. It is unique in that it reviews studies from the major disciplines in which aphasia research is conducted—cognitive neuropsychology, linguistics, neurology, neuroimaging, and speech-language pathology—as they apply to each topic of language. For each language domain, there are chapters devoted to theory and models of the language task, the neural basis of the language task (focusing on recent neuroimaging studies) and clinical diagnosis and treatment of impairments in that domain. In addition, there is broad coverage of approaches to investigation and treatment from leading experts, with several authors specializing in two or more disciplines. This second edition focuses on characterizing the cognitive and neural processes that account for each variant of aphasia as a first step toward developing effective rehabilitation, given that aphasia is one of the most common and disabling consequences of stroke. The best and most authoritative handbook in the field, The Handbook of Adult Language Disorders is the definitive reference for clinicians and researchers working in the scientific investigation of aphasia.
Rehabilitation helps individuals maintain and optimize independence. Historically, people with dementia have received little rehabilitation and the focus has been on care to replace lost function. Dementia Rehabilitation is a resource for health and social professionals, service planners, policy makers, and academics. The book makes a compelling case for rehabilitation for people with dementia, including the views of people with dementia and the research evidence. For each area of function, the research evidence and relevant theory is summarized, followed by practical information on clinical assessment, and delivery of therapies. Identifies rehabilitation as a human right for people with dementia. Reviews functions affected by dementia, including cognition, communication, and physical function. Outlines evidence-based strategies to maintain function and to delay decline. Describes how to maintain activities of daily living and leisure activities. Includes techniques to maintain self-identity and mood. Recognizes the importance of environment and care partners in supporting rehabilitation. Summarizes models of care for rehabilitation.
