Translational Approach to Heart Failure
Translational Approach to Heart Failure

Author: Jozef Bartunek

Publisher: Springer Science & Business Media

Published: 2013-07-13

Total Pages: 501

ISBN-13: 1461473454

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The refined pathophysiologal understanding of the heart failure syndrome together with the surge of new technological advances led to innovative medical and interventional treatment strategies improving the outcome of heart failure patients. However the complex interplay between the clinical presentation and the array of the interventions requires a coordinated multidisciplinary “heart team” approach involving various specialists in the cardiovascular field including clinicians, interventionalists, surgeons and cardiac intensivists. In this book, opinion leaders will review of state-of-the-art management of heart failure with particular emphasis on burning clinical questions and challenges faced by the heart team. New medical and interventional therapies for chronic and acute heart failure are addressed by bridging bench to bedside translation in science and technology into practical clinical application and guidance.

Translational Research in Coronary Artery Disease
Translational Research in Coronary Artery Disease

Author: Wilbert S. Aronow

Publisher: Academic Press

Published: 2015-10-29

Total Pages: 246

ISBN-13: 0128026057

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Translational Research in Coronary Artery Disease: Pathophysiology to Treatment covers the entire spectrum of basic science, genetics, drug treatment, and interventions for coronary artery disease. With an emphasis on vascular biology, this reference fully explains the fundamental aspects of coronary artery disease pathophysiology. Included are important topics, including endothelial function, endothelial injury, and endothelial repair in various disease states, vascular smooth muscle function and its interaction with the endothelium, and the interrelationship between inflammatory biology and vascular function. By providing this synthesis of current research literature, this reference allows the cardiovascular scientist and practitioner to access everything they need from one source. - Provides a concise summary of recent developments in coronary and vascular research, including previously unpublished data - Summarizes in-depth discussions of the pathobiology and novel treatment strategies for coronary artery disease - Provides access to an accompanying website that contains photos and videos of noninvasive diagnostic modalities for evaluation of coronary artery disease

Acute Heart Failure
Acute Heart Failure

Author: Alexandre Mebazaa

Publisher: Springer Science & Business Media

Published: 2009-12-24

Total Pages: 922

ISBN-13: 1846287820

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For many years, there has been a great deal of work done on chronic congestive heart failure while acute heart failure has been considered a difficult to handle and hopeless syndrome. However, in recent years acute heart failure has become a growing area of study and this is the first book to cover extensively the diagnosis and management of this complex condition. The book reflects the considerable amounts of new data reported and many new concepts which have been proposed in the last 3-4 years looking at the epidemiology, diagnostic and treatment of acute heart failure.

Cardiac Mechanotransduction
Cardiac Mechanotransduction

Author: Matti Weckström

Publisher: Springer Science & Business Media

Published: 2007-12-22

Total Pages: 158

ISBN-13: 0387488685

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This book presents a multidisciplinary approach to cardiac mechanotransduction. The chapters depict the many faces of the topic, from membrane and ion channel level to mechanics, biochemical signaling and regulation via hormone systems. Cardiac Mechanotransduction is of interest to basic life sciences, like physiology, biochemistry and pharmacology, but also to clinicians working with heart-related problems, such as cardiologists and internists.

Instructions for Geriatric Patients
Instructions for Geriatric Patients

Author: William Anthony Sodeman

Publisher: Saunders

Published: 2005

Total Pages: 492

ISBN-13:

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The resource American Family Physician called "a valuable and convenient source of educational guides" is back in an updated New Edition. All the most common diseases, conditions, and problems encountered in outpatient geriatric care are covered by 185 information sheets. Each sheet features an overview of the problem, important points of treatment, directions on when to contact a physician, and space for customized instructions. Plus, a bonus CD-ROM offers the instruction sheets in a handy electronic format! Improves compliance, calms concerns, and strengthens the doctor-patient relationship. Examines clinical conditions such as depression, heart failure, stroke, pneumonia, anemia as well as issues such as incontinence, falls, nutrition and diets, driving, end-of-life care, living wills, and much more. Addresses issues specific to caregivers and anticipates difficulties they encounter. Features perforated pages for ease of photocopying as well as customizable PDF versions of all 185 sheets on the bonus CD-ROM. Allows readers to add their own instructions with additional space provided on each printed topic sheet. Makes information easy to grasp with a large type size and a consistent, patient-friendly format. More than new 35 instructions that discusses SARS, PSA testing, macular degeneration, infections in diabetics, immunizations, and much more. Careful scrutiny and revision of all information sheets to ensure adherence to existing standards of care.

Principles of Translational Science in Medicine
Principles of Translational Science in Medicine

Author: Martin Wehling

Publisher: Academic Press

Published: 2015-04-02

Total Pages: 365

ISBN-13: 0128007214

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Principles of Translational Science in Medicine: From Bench to Bedside, Second Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing numbers of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine. - Provides an in-depth description of novel tools for the assessment of translatability of trials to balance risk and improve projects at any given stage of product development - New chapters deal with translational issues in the fastest growing population (the elderly), case studies, translatability assessment tools, and advances in nanotherapies - Details IPR issues of translation, especially for public-private-partnerships - Contains contributions from world leaders in translational medicine, including the former NIH director and authorities from various European regulatory institutions

Heart Failure in the Child and Young Adult
Heart Failure in the Child and Young Adult

Author: Joseph Rossano

Publisher: Academic Press

Published: 2017-12-05

Total Pages: 826

ISBN-13: 0128026138

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Heart Failure in the Child and Young Adult: From Bench to Bedside combines multiple etiologies for pediatric heart failure, including congenital heart disease, cardiomyopathies, infectious diseases and metabolic abnormalities. This comprehensive resource combines research from multiple contributors with current guidelines to bridge the knowledge gap for the recognition and management of heart failure in children. Coverage begins with the basic science of heart failure, then progresses through diagnosis, management, treatment and surgery, finally concluding with advanced special topics, including genetics, self-management and nanomedicine. - Provides coverage of the basic science of heart failure, its epidemiology and economic aspects, outpatient and inpatient management, and advanced therapies, including mechanical circulatory support and heart transplantation - Combines cutting-edge research with current guidelines from the field

Translational Pain Research
Translational Pain Research

Author: Lawrence Kruger

Publisher: CRC Press

Published: 2009-11-24

Total Pages: 458

ISBN-13: 1439812101

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One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practical

Dilated Cardiomyopathy
Dilated Cardiomyopathy

Author: Gianfranco Sinagra

Publisher: Springer

Published: 2019-05-17

Total Pages: 239

ISBN-13: 303013864X

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This open access book presents a comprehensive overview of dilated cardiomyopathy, providing readers with practical guidelines for its clinical management. The first part of the book analyzes in detail the disease’s pathophysiology, its diagnostic work up as well as the prognostic stratification, and illustrates the role of genetics and gene-environment interaction. The second part presents current and future treatment options, highlighting the importance of long-term and individualized treatments and follow-up. Furthermore, it discusses open issues, such as the apparent healing phenomenon, the early prognosis of arrhythmic events or the use of genetic testing in clinical practice. Offering a multidisciplinary approach for optimizing the clinical management of DCM, this book is an invaluable aid not only for the clinical cardiologists, but for all physicians involved in the care of this challenging disease.