Transfer RNAs and Other Soluble RNAs
Transfer RNAs and Other Soluble RNAs

Author: Joseph D. Cherayil

Publisher: CRC Press

Published: 1990-08-29

Total Pages: 182

ISBN-13: 9780849357442

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This fascinating book discusses various methods that have been used from early times to the present for the isolation and characterization of total tRNA, specific tRNAs, and small molecular weight RNAs. Filled with tables and figures, it presents comparative methods and provides an overview of the progress from a historical perspective. The text features chapters on special and recent methods, isolation of tRNA from specific sources, such as chloroplasts and mitochondria, purification, and identification of modified nucleotides. It also covers suppressor tRNAs, aminoacyl tRNA synthetases, and tRNA genes. This volume is an excellent resource for all biological chemists, microbiologists, and researchers.

TRNA
TRNA

Author: Dieter Söll

Publisher:

Published: 1995

Total Pages: 572

ISBN-13: 9781555818333

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Biology of Aminoacyl-tRNA Synthetases
Biology of Aminoacyl-tRNA Synthetases

Author:

Publisher: Academic Press

Published: 2020-10-23

Total Pages: 440

ISBN-13: 0128202610

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Biology of Aminoacyl-tRNA Synthetases, Volume 48 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on A narrative about our work on the endless frontier of editing, The puzzling evolution of aminoacyl-tRNA synthetases, Structural basis of the tRNA recognition by aminoacyl-tRNA synthetases, Catalytic strategies of aminoacyl-tRNA synthetases, Trans-editing by aminoacyl-tRNA synthetase-like editing domains, Adaptive and maladaptive mistranslation arising from aminoacyl-tRNA synthetases, Non-canonical inputs and outputs of tRNA aminoacylation, Structure and function of multi-tRNA synthetase complexes, Mitochondrial aminoacyl-tRNA synthetases, Non-canonical functions of human cytoplasmic tyrosyl-, tryptophanyl- and other aminoacyl-tRNA synthetases, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in The Enzymes series

Recoding: Expansion of Decoding Rules Enriches Gene Expression
Recoding: Expansion of Decoding Rules Enriches Gene Expression

Author: John F. Atkins

Publisher: Springer Science & Business Media

Published: 2010-03-10

Total Pages: 473

ISBN-13: 0387893822

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The literature on recoding is scattered, so this superb book ?lls a need by prov- ing up-to-date, comprehensive, authoritative reviews of the many kinds of recoding phenomena. Between 1961 and 1966 my colleagues and I deciphered the genetic code in Escherichia coli and showed that the genetic code is the same in E. coli, Xenopus laevis, and guinea pig tissues. These results showed that the code has been c- served during evolution and strongly suggested that the code appeared very early during biological evolution, that all forms of life on earth descended from a c- mon ancestor, and thus that all forms of life on this planet are related to one another. The problem of biological time was solved by encoding information in DNA and retrieving the information for each new generation, for it is easier to make a new organism than it is to repair an aging, malfunctioning one. Subsequently, small modi?cations of the standard genetic code were found in certain organisms and in mitochondria. Mitochondrial DNA only encodes about 10–13 proteins, so some modi?cations of the genetic code are tolerated that pr- ably would be lethal if applied to the thousands of kinds of proteins encoded by genomic DNA.

Translational Control of Gene Expression
Translational Control of Gene Expression

Author: Nahum Sonenberg

Publisher: CSHL Press

Published: 2001

Total Pages: 1034

ISBN-13: 9780879696184

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Since the 1996 publication of Translational Control, there has been fresh interest in protein synthesis and recognition of the key role of translation control mechanisms in regulating gene expression. This new monograph updates and expands the scope of the earlier book but it also takes a fresh look at the field. In a new format, the first eight chapters provide broad overviews, while each of the additional twenty-eight has a focus on a research topic of more specific interest. The result is a thoroughly up-to-date account of initiation, elongation, and termination of translation, control mechanisms in development in response to extracellular stimuli, and the effects on the translation machinery of virus infection and disease. This book is essential reading for students entering the field and an invaluable resource for investigators of gene expression and its control.

The Ribosome
The Ribosome

Author: Aleksandr S. Spirin

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 173

ISBN-13: 3642884466

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This monograph is neither a historical outline of the development of the concepts of protein biosynthesis and the structure and functions of the ribosomes, nor an exhaustive survey of the literature on these questions. The monograph is based upon an analysis of the modern trends in this field. The purpose of the monograph was to formulate more or less generalized representations of the structure and" function of the ribosome, as we envision it at the present day. It may be that this attempt is premature for a number of reasons, and the concepts outlined here will very soon be revised. Nonetheless, despite this risk, we believe it to be advisable to undertake this attempt for the following reasons: firstly, the undertaken analysis could aid in the comprehension of the substantial mass of extremely scattered experimental data on the ribosomes presently available; secondly, in any event, even if most of the concepts outlined rapidly become obselete, they can still serve as a stimulus for a whole series of experiments; and thirdly, we hope that some of the concepts outlined will still remain essentially correct and relatively stable. In view of the aforementioned, we should make the following reservations. First of all, we made no attempt to cite all the literature on the problems discussed, but considered it sufficient to illustrate the various premises with one or several sample references.

The Aminoacyl-tRNA Synthetases
The Aminoacyl-tRNA Synthetases

Author: Michael Ibba

Publisher: CRC Press

Published: 2005-04-01

Total Pages: 0

ISBN-13: 9781587061899

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By virtue of their role as catalysts of the aminoacylation reaction, the aminoacyl-tRNA synthetases ensure that the first step of translation is performed quickly and accurately. In this volume of 36 separate chapters, the many facets of this ancient and ubiquitous family are reviewed, including their surprising structural diversity, enzymology, tRNA interaction properties, and curious alternative functions. These chapters illustrate the degree to which the aminoacyl-tRNA synthetases employ a variety of mechanisms to carry out both the standard functions related to the synthesis of aminoacylated tRNA for protein synthesis, as well as the surprising functions associated with amino acid biosynthesis, cytokine function, and even the processivity of DNA replication. Other chapters explore the regulation of their synthesis, their role in disease, and their prospects as targets for antibacterial therapeutics. This monograph will be a valuable resource for all scientists interested in the fundamentals of protein synthesis from both a basic research and clinical perspective, as well as the relation of translational components to the evolution of the genetic code.