Toxicological Risks of Selected Flame-Retardant Chemicals
Toxicological Risks of Selected Flame-Retardant Chemicals

Author: National Research Council

Publisher: National Academies Press

Published: 2000-07-06

Total Pages: 534

ISBN-13: 0309171938

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Ignition of upholstered furniture by small open flames from matches, cigarette lighters, and candles is one of the leading causes of residential-fire deaths in the United States. These fires accounted for about 16% of civilian fire deaths in 1996. On average, each year since 1990, about 90 deaths (primarily of children), 440 injuries, and property losses amounting to 50 million dollars have resulted from fires caused by the ignition of upholstered furniture by small open flames. Certain commercial seating products (such as aircraft and bus seats) are subject to flammability standards and sometimes incorporate FR-treated upholstery cover materials, but there is no federal-government requirement for residential upholstered furniture, and it is generally not treated with FR chemicals. It is estimated that less than 0.2% of all U.S. residential upholstery fabric is treated with flame-retardant (FR) chemicals. The Consumer Product Safety Act of 1972 created the U.S. Consumer Product Safety Commission (CPSC) as an independent federal regulatory agency whose mission is to protect the public from unreasonable risks of injury and death associated with consumer products. CPSC also administers the Flammable Fabrics Act, under which it regulates flammability hazards and the Federal Hazardous Substances Act (FHSA), which regulates hazardous substances including chemicals. In 1993, the National Association of State Fire Marshals petitioned CPSC to issue a performance-based flammability standard for upholstered furniture to reduce the risk of residential fires. The Commission granted that portion of the petition relating to small open flame ignition risks. In response to concerns regarding the safety of FR chemicals, Congress, in the fiscal year 1999 appropriations report for CPSC, requested that the National Research Council conduct an independent study of the health risks to consumers posed by exposure to FR chemicals that are likely to be used in residential upholstered furniture to meet a CPSC standard. The National Research Council assigned the project to the Committee on Toxicology (COT) of the Commission on Life Sciences' Board on Environmental Studies and Toxicology. COT convened the Subcommittee on Flame-Retardant Chemicals, which prepared this report. Subcommittee members were chosen for their recognized expertise in toxicology, pharmacology, epidemiology, chemistry, exposure assessment, risk assessment, and biostatistics. Toxicological Risks of Selected Flame-Retardant Chemicals is organized into 18 chapters and two appendices. Chapter 2 describes the risk assessment process used by the subcommittee in determining the risk associated with potential exposure to the various FR chemicals. Chapter 3 describes the method the subcommittee used to measure and estimate the intensity, frequency, extent, and duration of human exposure to FR chemicals. Chapters 4-19 provide the subcommittee's review and assessment of health risks posed by exposure to each of the 16 FR chemicals. Data gaps and research needs are provided at the end of these chapters.

Polymer Green Flame Retardants
Polymer Green Flame Retardants

Author: Constantine D. Papaspyrides

Publisher: Newnes

Published: 2014-08-14

Total Pages: 943

ISBN-13: 0444538097

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Polymer Green Flame Retardants covers key issues regarding the response of polymers during fire, the mechanisms of their flame retardation, the regulations imposed on their use, and the health hazards arising from their combustion. Presenting the latest research developments, the book focuses in particular on nanocomposites, believed to be the most promising approach for producing physically superior materials with low flammability and ecological impact. The fire properties of nanocomposites of various matrixes and fillers are discussed, the toxicological characteristics of these materials are analyzed, addressing also their environmental sustainability. Edited by distinguished scientists, including an array of international industry and academia experts, this book will appeal to chemical, mechanical, environmental, material and process engineers, upper-level undergraduate and graduate students in these disciplines, and generally to researchers developing commercially attractive and environmentally friendly fire-proof products. - Provides recent findings on the manufacture of environmentally sustainable flame retardant polymeric materials - Covers legislation and regulations concerning flame retarded polymeric material use - Includes tables containing the fire properties of the most common polymeric materials

Toxicological Effects of Methylmercury
Toxicological Effects of Methylmercury

Author: National Research Council

Publisher: National Academies Press

Published: 2000-09-27

Total Pages: 364

ISBN-13: 0309171717

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Mercury is widespread in our environment. Methylmercury, one organic form of mercury, can accumulate up the aquatic food chain and lead to high concentrations in predatory fish. When consumed by humans, contaminated fish represent a public health risk. Combustion processes, especially coal-fired power plants, are major sources of mercury contamination in the environment. The U.S. Environmental Protection Agency (EPA) is considering regulating mercury emissions from those plants. Toxicological Effects of Methylmercury reviews the health effects of methylmercury and discusses the estimation of mercury exposure from measured biomarkers, how differences between individuals affect mercury toxicity, and appropriate statistical methods for analysis of the data and thoroughly compares the epidemiological studies available on methylmercury. Included are discussions of current mercury levels on public health and a delineation of the scientific aspects and policy decisions involved in the regulation of mercury. This report is a valuable resource for individuals interested in the public health effects and regulation of mercury. The report also provides an excellent example of the implications of decisions in the risk assessment process for a larger audience.

Toxicological Risks of Selected Flame-Retardant Chemicals
Toxicological Risks of Selected Flame-Retardant Chemicals

Author: National Research Council

Publisher: National Academies Press

Published: 2000-08-06

Total Pages: 534

ISBN-13: 0309070473

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Ignition of upholstered furniture by small open flames from matches, cigarette lighters, and candles is one of the leading causes of residential-fire deaths in the United States. These fires accounted for about 16% of civilian fire deaths in 1996. On average, each year since 1990, about 90 deaths (primarily of children), 440 injuries, and property losses amounting to 50 million dollars have resulted from fires caused by the ignition of upholstered furniture by small open flames. Certain commercial seating products (such as aircraft and bus seats) are subject to flammability standards and sometimes incorporate FR-treated upholstery cover materials, but there is no federal-government requirement for residential upholstered furniture, and it is generally not treated with FR chemicals. It is estimated that less than 0.2% of all U.S. residential upholstery fabric is treated with flame-retardant (FR) chemicals. The Consumer Product Safety Act of 1972 created the U.S. Consumer Product Safety Commission (CPSC) as an independent federal regulatory agency whose mission is to protect the public from unreasonable risks of injury and death associated with consumer products. CPSC also administers the Flammable Fabrics Act, under which it regulates flammability hazards and the Federal Hazardous Substances Act (FHSA), which regulates hazardous substances including chemicals. In 1993, the National Association of State Fire Marshals petitioned CPSC to issue a performance-based flammability standard for upholstered furniture to reduce the risk of residential fires. The Commission granted that portion of the petition relating to small open flame ignition risks. In response to concerns regarding the safety of FR chemicals, Congress, in the fiscal year 1999 appropriations report for CPSC, requested that the National Research Council conduct an independent study of the health risks to consumers posed by exposure to FR chemicals that are likely to be used in residential upholstered furniture to meet a CPSC standard. The National Research Council assigned the project to the Committee on Toxicology (COT) of the Commission on Life Sciences' Board on Environmental Studies and Toxicology. COT convened the Subcommittee on Flame-Retardant Chemicals, which prepared this report. Subcommittee members were chosen for their recognized expertise in toxicology, pharmacology, epidemiology, chemistry, exposure assessment, risk assessment, and biostatistics. Toxicological Risks of Selected Flame-Retardant Chemicals is organized into 18 chapters and two appendices. Chapter 2 describes the risk assessment process used by the subcommittee in determining the risk associated with potential exposure to the various FR chemicals. Chapter 3 describes the method the subcommittee used to measure and estimate the intensity, frequency, extent, and duration of human exposure to FR chemicals. Chapters 4-19 provide the subcommittee's review and assessment of health risks posed by exposure to each of the 16 FR chemicals. Data gaps and research needs are provided at the end of these chapters.

Green Toxicology
Green Toxicology

Author: Alexandra Maertens

Publisher: Royal Society of Chemistry

Published: 2022-02-01

Total Pages: 225

ISBN-13: 1839164409

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Green toxicology is an integral part of green chemistry. One of the key goals of green chemistry is to design less toxic chemicals. Therefore, an understanding of toxicology and hazard assessment is important for any chemist working in green chemistry, but toxicology is rarely part of most chemists' education. As a consequence, chemists lack the toxicological lens necessary to view chemicals in order to design safer substitutions. This book seeks to fill that gap and demonstrate how a basic understanding of toxicology, as well as the tools of in silico and in vitro toxicology, can be an integral part of green chemistry. R&D chemists, product stewards, and toxicologists who work in the field of sustainability, can all benefit from integrating green toxicology principles into their work. Topics include in silico tools for hazard assessment, toxicity testing, and lifecycle considerations, this book aims to act as a bridge between green toxicologists and green chemists.

Fire Toxicity
Fire Toxicity

Author: A A Stec

Publisher: Elsevier

Published: 2010-03-12

Total Pages: 721

ISBN-13: 184569807X

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Toxic fire effluents are responsible for the majority of fire deaths, and an increasing large majority of fire injuries, driven by the widespread and increasing use of synthetic polymers. Fire safety has focused on preventing ignition and reducing flame spread through reducing the rate of heat release, while neglecting the important issue of fire toxicity. This is the first reference work on fire toxicity and the only scientific publication on the subject in the last 15 years.Assessment of toxic effects of fires is increasingly being recognised as a key factor in the assessment of fire hazards. This book raises important issues including the types of toxic effluents that different fires produce, their physiological effects, methods for generation and assessment of fire toxicity, current and proposed regulations and approaches to modelling the toxic impact of fires.The contributors to Fire toxicity represent an international team of the leading experts in each aspect of this challenging and important field. This book provides an important reference work for professionals in the fire community, including fire fighters, fire investigators, regulators, fire safety engineers, and formulators of fire-safe materials. It will also prove invaluable to researchers in academia and industry. - Investigates the controversial subject of toxic effluents as the cause of the majority of fire deaths and injuries - Describes the different types of toxic effluents and the specific fires that they produce, their physiological effects and methods for generation - Provides an overview of national and international fire safety regulations including current and proposed regulations such as a standardized framework for prediction of fire gas toxicity

Health Effects of Beryllium Exposure
Health Effects of Beryllium Exposure

Author: National Research Council

Publisher: National Academies Press

Published: 2007-11-10

Total Pages: 108

ISBN-13: 0309111676

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Beryllium is an important metal that is used in a number of industries-including the defense, aerospace, automotive, medical, and electronics industries-because of its exceptional strength, stability, and heat-absorbing capability. It is found in a variety of technologies, including nuclear devices, satellite systems, missile systems, radar systems, bushings and bearings in aircraft and heavy machinery, x-ray machines used for mammography, cellular telephone components, computer components, and connectors for fiber optics. To help determine the steps necessary to protect its workforce from the adverse effects of exposure to beryllium used in military aerospace applications, the U.S. Air Force requested that the National Research Council's Committee on Toxicology (COT) conduct an independent evaluation of the scientific literature on beryllium, provide risk estimates for cancer and noncancer health end points, and make recommendations about specific tests for surveillance and biomonitoring of workers. The request specified that two reports be produced to accomplish those tasks. The first is to provide a review of the scientific literature on beryllium, and the second will expand more critically on the review in considering the maximum chronic inhalation exposure levels that are unlikely to produce adverse health effects, in estimating carcinogenic risks, and in providing guidance on testing methods for surveillance and monitoring of worker populations and other specific issues detailed in the statement of task. In response to the U.S. Air Force request, COT convened the Committee on Beryllium Alloy Exposures, which prepared this first report. Health Effects of Beryllium Exposure : A Literature Review identifies the available toxicologic, epidemiologic, and other literature on beryllium that is most relevant for addressing the statement of task, focusing primarily on beryllium sensitization, CBD, and cancer.

The Non-halogenated Flame Retardant Handbook
The Non-halogenated Flame Retardant Handbook

Author: Alexander B. Morgan

Publisher: John Wiley & Sons

Published: 2014-04-07

Total Pages: 314

ISBN-13: 1118939204

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A one-stop, practical handbook containing all of the current commercial non-halogenated flame retardant technologies as well as experimental systems near commercialization In response to the emphasis on replacing halogenated flame retardants with alternate technologies, this handbook focuses on existing non-halogenated flame retardants and the experimental close-to-production systems that are available today. The Non-Halogenated Flame Retardant Handbook starts with an overview of the regulations and customer perceptions driving non-halogenated flame retardant selections over older halogenated technologies. It then moves on to cover the known major classes of non-halogenated flame retardants, before concluding with the current niche-performing technologies and untried commercial contenders of the future. The Non-Halogenated Flame Retardant Handbook: Takes a practical approach to addressing the narrow subject of non-halogenated flame retardancy—placing more emphasis on flame retardant selection for specific plastics, practical considerations in flame retardant material design, and the various technologies’ strengths and limits Focuses on the proper use of non-halogenated flame retardants, rather than the mechanics of how they work Discusses important future trends in flame retardancy Features sections written by industrial and chemical experts who know how to apply the technology to polymers for fire safety needs

Flame-Retardant Polymeric Materials
Flame-Retardant Polymeric Materials

Author: Eli Pearce

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 463

ISBN-13: 1468421484

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Flammability has been recognized as an increasingly important social and scientific problem. Fire statistics in the United States (Report of the National Commission on Fire Prevention and Control. "America Burning:' 1973) emphasized the vast devastation to life and property--12.000 lives lost annually due to fire. and these deaths are usually caused by inhaling smoke or toxic gases: 300.000 fire injuries: 11.4 billion dollars in fire cost at which 2.7 billion dollars is related to property loss: a billion dollars to burn injury treatment: and 3.3 billion dollars in productivity loss. It is obvious that much human and economic misery can be attributed to fire situations. In relation to this. polymer flammability has been recognized as an in creasingly important social and scientific problem. The development of flame-retardant polymeric materials is a current example where the initia tive for major scientific and technological developments is motivated by sociological pressure and legislation. This is part of the important trend toward a safer environment and sets a pattern for future example. Flame retardancy deals with our basic everyday life situations-housing. work areas. transportation. clothing and so forth-the "macroenvironment" capsule within which "homosapiens" live. As a result. flame-retardant polymers are now emerging as a specific class of materials leading to new and diversified scientific and technological ventures.

Risk Assessment Methods
Risk Assessment Methods

Author: V.T. Covello

Publisher: Springer Science & Business Media

Published: 2013-06-29

Total Pages: 326

ISBN-13: 1489912169

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Much has already been written about risk assessment. Epidemiologists write books on how risk assessment is used to explore the factors that influence the distribution of disease in populations of people. Toxicologists write books on how risk assess ment involves exposing animals to risk agents and concluding from the results what risks people might experience if similarly exposed. Engineers write books on how risk assessment is utilized to estimate the risks of constructing a new facility such as a nuclear power plant. Statisticians write books on how risk assessment may be used to analyze mortality or accident data to determine risks. There are already many books on risk assessment-the trouble is that they all seem to be about different sUbjects! This book takes another approach. It brings together all the methods for assessing risk into a common framework, thus demonstrating how the various methods relate to one another. This produces four important benefits: • First, it provides a comprehensive reference for risk assessment. This one source offers readers concise explanations of the many methods currently available for describing and quantifying diverse types of risks. • Second, it consistently evaluates and compares available risk assessment methods and identifies their specific strengths and limitations. Understand ing the limitations of risk assessment methods is important. The field is still in its infancy, and the problems with available methods are disappoint ingly numerous. At the same time, risk assessment is being used.