Time of Our Lives
Time of Our Lives

Author: Tom Kirkwood

Publisher: Oxford University Press

Published: 2001-01-11

Total Pages: 288

ISBN-13: 0195350006

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By the year 2050 one in five of the world's population will be 65 or older, a fact which presages profound medical, biological, philosophical, and political changes in the coming century. In Time of Our Lives, Tom Kirkwood draws on more than twenty years of research to make sense of the evolution of aging, to explain how aging occurs, and to answer fundamental questions like why women live longer than men. He shows that we age because our genes, evolving at a time when life was "nasty, brutish, and short," placed little priority on the long-term maintenance of our bodies. With such knowledge, along with new insights from genome research, we can devise ways to target the root causes of aging and of age-related diseases such as Alzheimer's and osteoporosis. He even considers the possibility that human beings will someday have greatly extended life spans or even be free from senescence altogether. Beautifully written by one of the world's pioneering researchers into the science of aging, Time of Our Lives is a clear, original and, above all, inspiring investigation of a process all of us experience but few of us understand.

Time of Our Lives
Time of Our Lives

Author: Tom Kirkwood

Publisher:

Published: 2000

Total Pages: 277

ISBN-13: 9780753809204

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In this text, Thomas Kirkwood examines closely why we age, how human ageing compares to that of other animal species, what the menopause is for, why our memories fail as we get older and whether cancer is inevitable. Looking at the subject from a variety of perspectives, the book also projects us hundreds of years into a future where most of the symptoms of ageing have been conquered - and shows us what society could be like.

Time of Our Lives
Time of Our Lives

Author: Tom Kirkwood

Publisher:

Published: 1999-11

Total Pages: 277

ISBN-13: 9780756761530

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In Time of Our Lives, Tom Kirkwood unfolds some of the deepest mysteries of medical science while demolishing some of the most persistent misconceptions. He overturns the almost universally held belief that aging is either necessary or inevitable - it isn't - and debunks the idea that there exists a "death gene" that evolved to inhibit population growth. Instead, Kirkwood shows that we age because our genes, evolving at a time when life was "nasty, brutish, and short," placed little priority on the long-term maintenance of our bodies. With such knowledge, along with new insights from genome research, we can devise ways to target the root causes of aging and of age-related diseases such as Alzheimer's and osteoporosis. Expanding the thesis of the "disposable soma," developed over twenty years of research, Kirkwood makes sense of the evolution of aging, explains how aging occurs, and answers fundamental questions like why women live longer than men. He even considers the possibility that human beings will someday have greatly extended life spans or even be free from senescence altogether.

Epigenetics of Aging
Epigenetics of Aging

Author: Trygve O. Tollefsbol

Publisher: Springer Science & Business Media

Published: 2009-11-11

Total Pages: 462

ISBN-13: 1441906398

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Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.

The Art and Science of Aging Well
The Art and Science of Aging Well

Author: Mark E. Williams, M.D.

Publisher: UNC Press Books

Published: 2016-06-22

Total Pages: 241

ISBN-13: 146962740X

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In the past century, average life expectancies have nearly doubled, and today, for the first time in human history, many people have a realistic chance of living to eighty or beyond. As life expectancy increases, Americans need accurate, scientifically grounded information so that they can take full responsibility for their own later years. In The Art and Science of Aging Well, Mark E. Williams, M.D., discusses the remarkable advances that medical science has made in the field of aging and the steps that people may take to enhance their lives as they age. Through his own observations and by use of the most current medical research, Williams offers practical advice to help aging readers and those who care for them enjoy personal growth and approach aging with optimism and even joy. The Art and Science of Aging Well gives a realistic portrait of how aging occurs and provides important advice for self-improvement and philosophical, spiritual, and conscious evolution. Williams argues that we have considerable choice in determining the quality of our own old age. Refuting the perspective of aging that insists that personal, social, economic, and health care declines are persistent and inevitable, he takes a more holistic approach, revealing the multiple facets of old age. Williams provides the resources for a happy and productive later life.

The Long and the Short of It
The Long and the Short of It

Author: Jonathan Silvertown

Publisher: University of Chicago Press

Published: 2013-11-01

Total Pages: 203

ISBN-13: 022607210X

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“[A] whimsical book on aging . . . the author mixes art, science, and humor to brew a highly readable concoction, presenting one aging theory after another.” —Publishers Weekly Everything that lives will die. That’s the fundamental fact of life. But not everyone dies at the same age: people vary wildly in their patterns of aging and their life spans—and that variation is nothing compared to what’s found in other animal and plant species. With The Long and the Short of It, biologist and writer Jonathan Silvertown offers readers a witty and fascinating tour through the scientific study of longevity and aging. Dividing his daunting subject by theme—death, life span, aging, heredity, evolution, and more—Silvertown draws on the latest scientific developments to paint a picture of what we know about how life span, senescence, and death vary within and across species. At every turn, he addresses fascinating questions that have far-reaching implications: What causes aging, and what determines the length of an individual life? What changes have caused the average human life span to increase so dramatically—fifteen minutes per hour—in the past two centuries? If evolution favors those who leave the most descendants, why haven’t we evolved to be immortal? The answers to these puzzles and more emerge from close examination of the whole natural history of life span and aging, from fruit flies, nematodes, redwoods, and much more. The Long and the Short of It pairs a perpetually fascinating topic with a wholly engaging writer, and the result is a supremely accessible book that will reward curious readers of all ages. “Captivating and enlightening.” —The New York Times Well Blog

Aging
Aging

Author: Harry R. Moody

Publisher: SAGE Publications

Published: 2017-01-12

Total Pages: 609

ISBN-13: 1506327990

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Presenting current research in an innovative text-reader format, Aging: Concepts and Controversies, Ninth Edition encourages students to become involved and take an informed stand on the major aging issues we face as a society. Not simply a summary of research literature, Harry R. Moody and Jennifer R. Sasser’s text focuses on controversies and questions, rather than on assimilating facts or arriving at a single "correct" view about aging and older people. Drawing on their extensive expertise, the authors first provide an overview of aging in three domains: aging over the life course, health care, and the socioeconomic aspects of aging. Each section is followed by a series of edited readings, offering different perspectives from experts and specialists on that subject. New readings focus on whether current federal spending on the elderly is sustainable and fair to other groups, how older consumers are reshaping the business landscape, and the challenges of marketing and selling to customers 60 and over. More emphasis is placed on how social class and inequality earlier in life can shape our final years and the number of older Americans living in poverty. The section on Aging and Health Care has been thoroughly updated to reflect the latest data about chronic diseases that affect the elderly, government spending on health care, and policy changes to programs like Medicaid and Medicare. The section on the Social and Economic Outlook for an Aging Society gives the most current picture of the racial and ethnic diversity of older Americans, their participation in the labor force, and their income and wealth.

The Biostatistics of Aging
The Biostatistics of Aging

Author: Gilberto Levy

Publisher: John Wiley & Sons

Published: 2014-02-11

Total Pages: 268

ISBN-13: 1118645820

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A practical and clarifying approach to aging and aging-related diseases Providing a thorough and extensive theoretical framework, The Biostatistics of Aging: From Gompertzian Mortality to an Index of Aging-Relatedness addresses the surprisingly subtlenotion—with consequential biomedical and public health relevance—of what it means for acondition to be related to aging. In this pursuit, the book presents a new quantitative methodto examine the relative contributions of genetic and environmental factors to mortality anddisease incidence in a population. With input from evolutionary biology, population genetics, demography, and epidemiology, this medically motivated book describes an index of aging-relatedness and also features: Original results on the asymptotic behavior of the minimum of time-to-event random variables, which extends those of the classical statistical theory of extreme values A comprehensive and satisfactory explanation based on biological principles of the Gompertz pattern of mortality in human populations The development of an evolution-based model of causation relevant to mortality and aging-related diseases of complex etiology An explanation of how and why the description of human mortality by the Gompertz distribution can be improved upon from first principles The amply illustrated analysis of real-world data, including a program for conducting the analysis written in the freely available R statistical software Technical appendices including mathematical material as well as an extensive and multidisciplinary bibliography on aging and aging-related diseases The Biostatistics of Aging: From Gompertzian Mortality to an Index of Aging-Relatedness is an excellent resource for practitioners and researchers with an interest in aging and aging-related diseases from the fields of medicine, biology, gerontology, biostatistics, epidemiology, demography, and public health.

The Fountain of Youth
The Fountain of Youth

Author: Stephen G. Post

Publisher: Oxford University Press

Published: 2004-04-08

Total Pages: 490

ISBN-13: 0195170083

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If effective anti-aging interventions were achieved, they would likely bring about profound alterations in the experiences of individual and collective life. What if modern scientists could find the modern equivalent to the Fountain of Youth that Ponce de Leon sought? This book addresses this question by exploring the ramifications of possible anti-aging interventions on both individual and collective life. Through a series of essays, it examines the biomedical goal of prolongevity from cultural, scientific, religious, and ethical perspectives, offering a sweeping view into the future of aging.