Thermodynamics of Membrane Receptors and Channels
Thermodynamics of Membrane Receptors and Channels

Author: Meyer B. Jackson

Publisher: CRC Press

Published: 1992-11-18

Total Pages: 454

ISBN-13: 9780849369087

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Thermodynamics of Membrane Receptors and Channels synthesizes a wealth of new information regarding the biophysics of membrane proteins. New insights provided by molecular genetics, single channel recording, and high resolution structural techniques are discussed from a conceptual perspective. Basic theoretical topics are introduced, developed, and then extensively illustrated with recent results from the literature or data from the authors' own laboratories. Theoretical and experimental information is incorporated into in-depth discussions of ion permeation mechanisms, ion channel and receptor conformational changes, aggregate activity of complexes of lipids and proteins, and how coupling is achieved between different energy modes in the many transduction systems residing in biomembranes. Thermodynamics of Membrane Receptors and Channels will be valuable both as a learning aid and a reference for biophysicists, neuroscientists, cell biologists, physiologists, and other researchers investigating any aspects of biomembranes.

TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades
TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades

Author: Wolfgang B. Liedtke, MD, PH.D.

Publisher: CRC Press

Published: 2006-09-29

Total Pages: 502

ISBN-13: 1420005847

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Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of st

Ionic Channels of Excitable Membranes
Ionic Channels of Excitable Membranes

Author: Bertil Hille

Publisher: Sinauer Associates, Incorporated

Published: 1992

Total Pages: 638

ISBN-13:

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This new, fully revised and expanded edition of Ionic Channels of Excitable Membranes includes new chapters on fast chemical synapses, modulation through G protein coupled receptors and second messenger systems, molecules cloning, site directed mutagenesis, and cell biology. It begins with the classical biophysical work of Hodgkin and Huxley and then weaves a description of the known ionic channels together with their biological functions. The book continues by developing the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ionic Channels of Excitable Membranes is written to be accessible and interesting to biological and physical scientists of all kinds.

Physicochemical & Environmental Plant Physiology
Physicochemical & Environmental Plant Physiology

Author: Park S. Nobel

Publisher: Academic Press

Published: 1999

Total Pages: 518

ISBN-13: 9780125200257

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In fundamental ways, the functioning of all living systems obeys the laws of physics and chemistry. This is true for all physiological processes that occur inside cells, tissues, organs, and organisms. This new edition of a classic text has been throughly revised while maintaining its unparalleled commitment to the clear presentation and student user-friendliness. Certain to maintain its leading role in the teaching of general and comparative physiological principles, Physicochemical and Environmental Plant Physiology, 2nd Edition establishes a new standard of excellence in the teaching of quantitative plant physiology.

Information Processing And Living Systems
Information Processing And Living Systems

Author: Vladimir B Bajic

Publisher: World Scientific

Published: 2005-06-01

Total Pages: 799

ISBN-13: 1783260270

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Information processing and information flow occur in the course of an organism's development and throughout its lifespan. Organisms do not exist in isolation, but interact with each other constantly within a complex ecosystem. The relationships between organisms, such as those between prey or predator, host and parasite, and between mating partners, are complex and multidimensional. In all cases, there is constant communication and information flow at many levels.This book focuses on information processing by life forms and the use of information technology in understanding them. Readers are first given a comprehensive overview of biocomputing before navigating the complex terrain of natural processing of biological information using physiological and analogous computing models. The remainder of the book deals with “artificial” processing of biological information as a human endeavor in order to derive new knowledge and gain insight into life forms and their functioning. Specific innovative applications and tools for biological discovery are provided as the link and complement to biocomputing.Since “artificial” processing of biological information is complementary to natural processing, a better understanding of the former helps us improve the latter. Consequently, readers are exposed to both domains and, when dealing with biological problems of their interest, will be better equipped to grasp relevant ideas.

Membrane Transport and Renal Physiology
Membrane Transport and Renal Physiology

Author: Harold E. Layton

Publisher: Springer Science & Business Media

Published: 2002-08-06

Total Pages: 438

ISBN-13: 9780387954813

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The papers in this volume arose out of the workshop Membrane Transport and Renal Physiology, which was conducted as part of the IMA 1998-1999 program year, Mathematics in Biology. The workshop brought together physiologists, biophysicists, and applied mathematicians who share a common interest in solute and water transport in biological systems, especially in the integrated function of the kidney. Solute and water transport through cells involves fluxes across two cell membranes, usually via specialized proteins that are integral membrane components. By means of mathematical representations, transport fluxes can be related to transmembrane solute concentrations and electrochemical driving forces. At the next level of functional integration, these representations can serve as key components for models of renal transcellular transport. Ultimately, simulations can be developed for transport-dependent aspects of overall renal function. Workshop topics included solute fluxes through ion channels, cotransporters, and metabolically-driven ion pumps; transport across fiber-matrix and capillary membranes; coordinated transport by renal epithelia; the urine concetrating mechanism; and intra-renal hemodynamic control. This volume will be of interest to biological and mathematical scientists who would like a view of recent mathematical efforts to represent membrane transport and its role in renal function.

Mobility and Proximity in Biological Membranes
Mobility and Proximity in Biological Membranes

Author: S. Damjanovich

Publisher: CRC Press

Published: 2018-01-18

Total Pages: 347

ISBN-13: 1351083120

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Cell surface membranes have long been characterized as two-dimensional fluids whose mobile components are randomized by diffusion in the plane of the membrane bilayer. Recent research has indicated that cell surface membranes are highly organized and ordered and that important functional units of membranes appear as arrays of interacting molecules rather than as single, freely diffusing molecules. Mobility and Proximity in Biological Membranes provides an overview of the results obtained from biophysical methods for probing the organization of cell surface membranes. These results are presented in the context of detailed treatments of the theory and the technical demands of each of the methods. The book describes a versatile and easily applied mode for investigating molecular proximities in plasma membranes in a flow cytometer. Its analysis of lipid fluidity and viscosity of membranes and the rotational mobility of proteins offers intimate insight into the physical chemistry of biological membranes. The electrophysiology of lymphocytes is presented with focus on its importance in different diseases. New techniques are described, and new data, new possibilities, and future trends are presented by world experts. This book's chapters can serve both as guides to the existing literature and as starting points for new experiments and approaches associated with problems in membrane function.

Mechanosensitive Ion Channels, Part A
Mechanosensitive Ion Channels, Part A

Author:

Publisher: Elsevier

Published: 2011-09-21

Total Pages: 444

ISBN-13: 0080488633

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Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. This series has been a mainstay for practicing scientists and students interested in this critical field of biology. Articles covered in the volume include The Mechanical Properties of Bilayers; Molecular Dynamic Modeling of MS Channels; Structures of the Prokaryotic Mechanosensitive; Channels MscL and MscS; 3.5 Billion Years of Mechanosensory Transduction: Structure and Function of Mechanosensitive Channels in Prokaryotes; Activation of Mechanosensitive Ion Channels by Forces Transmitted through Integrins and the Cytoskeleton; Thermodynamics of Mechanosensitivity; Flexoelectricity and Mechanotransduction; Lipid Effects on Mechanosensitive Channels; Functional Interactions of the Extracellular Matrix with Mechanosensitive Channels; MSCL: The Bacterial Mechanosensitive Channel of Large Conductance; The Bacterial Mechanosensitive Channel MscS: Emerging Principles of Gating and Modulation; Structure function relations of MscS; The MscS Cytoplasmic Domain and its Conformational Changes upon the Channel Gating; Microbial TRP Channels and Their Mechanosensitivity; MSCS-Like Proteins in Plants; Delivering Force and Amplifying Signals in Plant Mechanosensing; MS Channels in Tip Growing Systems.

Cell Volume and Signaling
Cell Volume and Signaling

Author: Peter Lauf

Publisher: Springer Science & Business Media

Published: 2006-11-30

Total Pages: 441

ISBN-13: 0387237526

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In front of you is the finished product of your work, the text of your contributions to the 2003 Dayton International Symposium on Cell Volume and Signal Transduction. As we all recall, this symposium brought together the Doyens of Cellular and Molecular Physiology as well as aspiring young investigators and students in this field. It became a memorable event in an illustrious series of International Symposia on Cell Volume and Signaling. This series, started by Professors Vladimir Strbák, Florian Lang and Monte Greer in Smolenice, Slovakia in 1997 and continued by Professors Rolf Kinne, Florian Lang and Frank Wehner in Berlin in 2000, is projected for 2005 in Copenhagen to be hosted by our colleague, Professor Else Hoffmann and her team. We dearly miss Monte Greer to whom this symposium was dedicated and addressed so eloquently by Vladimir Strbák in his Dedication to Monte. Monte and I became friends in Smolenice and had begun to discuss the 2003 meeting only a few days before his tragic accident in 2002. There are others who were not with us, and we missed them, too. We would not have been able to succeed in this event without the unflagging support of our higher administration at Wright State University, the NIDDKD of the National Institute of Health, and the Fuji Medical System (see Acknowledgments).