The World of Nano-Biomechanics

The World of Nano-Biomechanics

Author: Atsushi Ikai

Publisher: Elsevier

Published: 2016-11-18

Total Pages: 342

ISBN-13: 0444636870

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The World of Nano-Biomechanics, Second Edition, focuses on the remarkable progress in the application of force spectroscopy to molecular and cellular biology that has occurred since the book's first edition in 2008. The initial excitement of seeing and touching a single molecule of protein/DNA is now culminating in the development of various ways to manipulate molecules and cells almost at our fingertips, enabling live cell operations. Topics include the development of molecular biosensors, mechanical diagnosis, cellular-level wound healing, and a look into the advances that have been made in our understanding of the significance of mechanical rigidity/flexibility of protein/DNA structure for the manifestation of biological activities. The book begins with a summary of the results of basic mechanics to help readers who are unfamiliar with engineering mechanics. Then, representative results obtained on biological macromolecules and structures, such as proteins, DNA, RNA, polysaccharides, lipid membranes, subcellular organelles, and live cells are discussed. New to this second edition are recent developments in three important applications, i.e., advanced AFM-data analysis, high-resolution mechanical biosensing, and the use of cell mechanics for medical diagnosis. Explains the basic physical concepts and mathematics of elementary mechanics needed to understand and perform experimental work on small-scale biological samples Presents recent developments of force-based biosensing Includes novel applications of nano-biomechanics to the medical field


The World of Nano-Biomechanics

The World of Nano-Biomechanics

Author: Atsushi Ikai

Publisher: Elsevier

Published: 2007-11-02

Total Pages: 301

ISBN-13: 0080556043

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By using nanotechnological methods, we can now poke around protein molecules, genes, membranes, cells and more. Observation of such entities through optical and electron microscopes tempt us to touch and manipulate them. It is now possible to do so, and scientists around the world have started pulling, pushing and cutting small structures at the base of life processes to understand the effect of our hand work.The book describes the physical properties of such life supporting structures from the molecular level with a special emphasis on their designs based on the mechanical strength and flexibility, membrane and other biological nanostructures. - Describes the basic mechanical features of proteins, DNA, cell membrane and other biological nanostructures - Explains the basic concepts and mathematics of elementary mechanics needed to understand and perform experimental work


The World of Nano-Biomechanics

The World of Nano-Biomechanics

Author: Atsushi Ikai

Publisher: Elsevier

Published: 2016-12-15

Total Pages: 412

ISBN-13: 9780444636867

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"The World of Nano-Biomechanics, Second Edition, "focuses on the remarkable progress in the application of force spectroscopy to molecular and cellular biology that has occurred since the book's first edition in 2008. The initial excitement of seeing and touching a single molecule of protein/DNA is now culminating in the development of various ways to manipulate molecules and cells almost at our fingertips, enabling live cell operations. Topics include the development of molecular biosensors, mechanical diagnosis, cellular-level wound healing, and a look into the advances that have been made in our understanding of the significance of mechanical rigidity/flexibility of protein/DNA structure for the manifestation of biological activities. The book begins with a summary of the results of basic mechanics to help readers who are unfamiliar with engineering mechanics. Then, representative results obtained on biological macromolecules and structures, such as proteins, DNA, RNA, polysaccharides, lipid membranes, sub-cellular organelles, and live cells are discussed. New to this second edition are recent developments in two important applications, i.e., high-resolution mechanical biosensors and the use of cell mechanics for medical diagnosis. Fully revised and expanded new edition based on the latest research and developments in the fieldExplains the basic physical concepts and mathematics of elementary mechanics needed to understand and perform experimental work Presents recent developments of force-based biosensorsIncludes novel applications of nano-biomechanics to the medical field


Integrated Nano-Biomechanics

Integrated Nano-Biomechanics

Author: Takami Yamaguchi

Publisher: William Andrew

Published: 2018-06-27

Total Pages: 316

ISBN-13: 0323389597

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Integrated Nano-Biomechanics provides an integrated look into the rapidly evolving field of nanobiomechanics. The book demystifies the processes in living organisms at the micro- and nano-scale through mechanics, using theoretical, computational and experimental means. The book develops the concept of integrating different technologies along the hierarchical structure of biological systems and clarifies biomechanical interactions among different levels for the analysis of multi-scale pathophysiological phenomena. With a focus on nano-scale processes and biomedical applications, it is shown how knowledge obtained can be utilized in a range of areas, including diagnosis and treatment of various human diseases and alternative energy production. This book is based on collaboration of researchers from a unique combination of fields, including biomechanics, computational mechanics, GPU application, electron microscopy, biology of motile micro-organisms, entomological mechanics and clinical medicine. The book will be of great interest to scientists and researchers involved in disciplines, such as micro- and nano-engineering, bionanotechnology, biomedical engineering, micro- and nano-scale fluid-mechanics (such as in MEMS devices), nanomedicine and microbiology, as well as industries such as optical devices, computer simulation, plant based energy sources and clinical diagnosis of the gastric diseases. Provides knowledge of integrated biomechanics, focusing on nano-scale, in this rapidly growing research field Explains how the different technologies can be integrated and applied in a variety of biomedical application fields, as well as for alternative energy sources Uses a collaborative, multidisciplinary approach to provide a comprehensive coverage of nano-biomechanics


Biomechanics At Micro- And Nanoscale Levels - Volume Iii

Biomechanics At Micro- And Nanoscale Levels - Volume Iii

Author: Hiroshi Wada

Publisher: World Scientific

Published: 2007-06-22

Total Pages: 182

ISBN-13: 9814474843

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A project on “Biomechanics at Micro- and Nanoscale Levels”, the title of this book, was approved by the Ministry of Education, Culture, Sports, Science and Technology of Japan in 2003; and this four-year project is now being carried out by fourteen prominent Japanese researchers.At the 5th World Congress of Biomechanics held in Munich, Germany, from 29th July to 4th August, 2006, we organized the following sessions: Thread 3: Biomechanics at micro- and nanoscale levels — (1) cell mechanics; (2) molecular biomechanics; (3) mechanobiology at micro- and nanoscale levels; and (4) computational biomechanics. The present proceedings volume covers topics related to these sessions, and follows on from where the previous two volumes left off. This book is essential reading for those interested in understanding current trends of research in the area of biomechanics at micro- and nanoscale levels.


Biomechanics

Biomechanics

Author: Manuel Doblare

Publisher: EOLSS Publications

Published: 2015-12-30

Total Pages: 498

ISBN-13: 178021023X

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Biomechanics is a component of Encyclopedia of Physical Sciences, Engineering and Technology Resources in the global Encyclopedia of Life Support Systems (EOLSS), which is an integrated compendium of twenty one Encyclopedias. The enormous progress in the field of health sciences that has been achieved in the 19th and 20th centuries would have not been possible without the enabling interaction and support of sophisticated technologies that progressively gave rise to a new interdisciplinary field named alternatively as bioengineering or biomedical engineering. Although both terms are synonymous, the latter is less general since it limits the field of application to medicine and clinical practice, while the former covers semantically the whole field of interaction between life sciences and engineering, thus including also applications in biology, biochemistry or the many '-omics'. We use in this book the second, with more general meaning, recalling the very important relation between fundamental science and engineering. And this also recognizes the tremendous economic and social impacts of direct application of engineering in medicine that maintains the health industry as one with the fastest growth in the world economy. Biomechanics, in particular, aims to explain and predict the mechanics of the different components of living beings, from molecules to organisms as well as to design, manufacture and use of any artificial device that interacts with the mechanics of living beings. It helps, therefore, to understand how living systems move, to characterize the interaction between forces and deformation along all spatial scales, to analyze the interaction between structural behavior and microstructure, with the very important particularity of dealing with adaptive systems, able to adapt their internal structure, size and geometry to the particular mechanical environment in which they develop their activity, to understand and predict alterations in the mechanical function due to injuries, diseases or pathologies and, finally, to propose methods of artificial intervention for functional diagnosis or recovery. Biomechanics is today a very highly interdisciplinary subject that attracts the attention of engineers, mathematicians, physicists, chemists, material specialists, biologists, medical doctors, etc. They work in many different topics from a purely scientific objective to industrial applications and with an increasing arsenal of sophisticated modeling and experimental tools but always with the final objectives of better understanding the fundamentals of life and improve the quality of life of human beings. One purpose in this volume has been to present an overview of some of these many possible subjects in a self-contained way for a general audience. This volume is aimed at the following major target audiences: University and College Students, Educators, Professional Practitioners, and Research Personnel.


Biomechanics At Micro- And Nanoscale Levels - Volume I

Biomechanics At Micro- And Nanoscale Levels - Volume I

Author: Hiroshi Wada

Publisher: World Scientific

Published: 2005-01-04

Total Pages: 183

ISBN-13: 9814481386

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This book is essential reading for those interested in understanding current trends of research in the area of biomechanics at micro- and nanoscale levels. It details the research carried out to date in this field by fourteen prominent researchers as part of a four-year government supported project which commenced in 2003. It consists of four chapters entitled Cell Mechanics, Cell Response to Mechanical Stimulation, Tissue Engineering and Computational Biomechanics.


Biomechanics At Micro- And Nanoscale Levels - Volume Iv

Biomechanics At Micro- And Nanoscale Levels - Volume Iv

Author: Hiroshi Wada

Publisher: World Scientific

Published: 2007-09-24

Total Pages: 181

ISBN-13: 9814474258

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A project on “Biomechanics at Micro- and Nanoscale Levels”, the title of this book, was approved by the Ministry of Education, Culture, Sports, Science and Technology of Japan in 2003. This 4-year-project was carried out by 14 prominent Japanese researchers and ended in late March 2007. The project consisted of four fields of research, namely, cell mechanics, cell response to mechanical stimulation, tissue engineering, and computational biomechanics.A series of four books related to this project was published between 2003 and 2007. The present volume is the last book in this series, and summarizes the research results achieved by project members throughout its 4-year duration. This book is essential reading for those interested in understanding current trends of research in the area of biomechanics at micro- and nanoscale levels.