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Author: Toshio Takeda
Publisher: Elsevier Science & Technology
Published: 1994
Total Pages: 482
ISBN-13:
DOWNLOAD EBOOKA summary of studies using Senescence Accelerated Mouse (SAM). Research on SAM is directed to investigations on the pathogenesis of age-associated disorders; on effective methods to modulate the advance of senescence; and on the underlying mechanisms in primary ageing processes.
Author: Stephen Bondy
Publisher: Springer Science & Business Media
Published: 2010-09-02
Total Pages: 468
ISBN-13: 1607616025
DOWNLOAD EBOOKFeatures that characterize the aging process include the gradual accumulation of cell damage after prolonged exposure to oxidative and inflammatory events over a lifetime. In addition to the accretion of lesions, the intrinsic levels of pro-oxidant and aberrant immune responses are elevated with age. These adverse events are often further enhanced by the chronic and slow progressing diseases that characterize the senescent brain and cardiovascular system. The incidence of some disorders such as Alzheimer's disease and vascular diseases are sufficiently prevalent in the extreme elderly that these disorders can arguably be considered "normal". Aging and Aging-Related Disorders examines the interface between normal and pathological aging, and illustrates how this border can sometimes be diffuse. It explores and illustrates the processes underlying the means by which aging becomes increasingly associated with inappropriate levels of free radical activity and how this can serve as a platform for the progression of age-related diseases. The book provides chapters that examine the interactive relationship between systems in the body that can enhance or sometimes even limit cellular longevity. In addition, specific redox mechanisms in cells are discussed. Another important aspect for aging discussed here is the close relationship between the systems of the body and exposure to environmental influences of oxidative stress that can affect both cellular senescence and a cell’s nuclear DNA. What may be even more interesting to note is that these external stressors are not simply confined to illnesses usually associated with aging, but can be evident in maturing and young individuals. A broad range of internationally recognized experts have contributed to this book. Their aim is to successfully highlight emerging knowledge and therapy for the understanding of the basis and development of aging–related disorders.
Author: Claudine Sauvain-Dugerdil
Publisher: Peter Lang
Published: 2006
Total Pages: 372
ISBN-13: 9783039107858
DOWNLOAD EBOOKAge is a complex cross-cutting notion for at least two reasons: the intricate interweaving of its biological and socio-cultural meanings and its dual significance as both a benchmark in an individual's life course and a foundation for social structure. This book offers new perspectives on age and ageing by combining achievements in the biological sciences and their different applications and interpretations in demography, anthropology, psychology and other pertinent disciplines. Thirty contributors from these various fields revisit the measures and the biological models of ageing, the borderline between normal and pathological ageing, the pertinence of chronological age as a benchmark along the life course, its interrelations with psychological development, with reproductive phases and other life events, the «normalizing» role ascribed by age classes and the risk of falling into ageism, the cross-cultural diversity and temporal changes of its meanings, the gender divide (real and perceived), as well as the rights that should be enjoyed at each age.
Author: P. Michael Conn
Publisher: Elsevier
Published: 2011-04-28
Total Pages: 1103
ISBN-13: 0080460062
DOWNLOAD EBOOKThe Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues. - Utilizes a multidisciplinary approach - Shows tricks and approaches not available in primary publications - First volume of its kind to combine both methods of study for human aging and animal models - Over 200 illustrations
Author: Shigenobu Kanba
Publisher: Routledge
Published: 2013-04-15
Total Pages: 147
ISBN-13: 1135063133
DOWNLOAD EBOOKPublished in 1999, Herbal Medicines for Neuropsychiatric Diseases is a valuable contribution to the field of Psychiatry/Clinical Psychology.
Author: Douglas E. Crews
Publisher: Cambridge University Press
Published: 2003-12-11
Total Pages: 306
ISBN-13: 9781139441162
DOWNLOAD EBOOKMuch research on the biology of senescence is on cell-lines, nematodes or fruit flies, that are only of peripheral relevance to the problems encountered in humans. Human Senescence is a text which reviews the evolutionary biology of human senescence and life span, and the evolutionarily recent development of late-life survival. It examines how human patterns of and variability in growth and development have altered later life survival probabilities and competencies, and how survival during mid-life contributes to senescent dysfunction and alteration. Discussing possibilities of further extending human life span, it gives a better understanding of how humans came to senesce as slowly as we do over our lifespan. Bringing together gerontological, anthropological and biocultural research, it explores human variation in chronic disease, senescence and life span as outcomes of early life adaptation and the success of humankind's sociocultural evolution. It is a benchmark publication for all interested in how and why we age.
Author: Se-Kwon Kim
Publisher: Springer
Published: 2014-11-27
Total Pages: 801
ISBN-13: 3319071459
DOWNLOAD EBOOKThis timely desk reference focuses on marine-derived bioactive substances which have biological, medical and industrial applications. The medicinal value of these marine natural products are assessed and discussed. Their function as a new and important resource in novel, anticancer drug discovery research is also presented in international contributions from several research groups. For example, the potential role of Spongistatin, Apratoxin A, Eribulin mesylate, phlorotannins, fucoidan, as anticancer agents is explained. The mechanism of action of bioactive compounds present in marine algae, bacteria, fungus, sponges, seaweeds and other marine animals and plants are illustrated via several mechanisms. In addition, this handbook lists various compounds that are active candidates in chemoprevention and their target actions. The handbook also places into context the demand for anticancer nutraceuticals and their use as potential anti-cancer pharmaceuticals and medicines. This study of advanced and future types of natural compounds from marine sources is written to facilitate the understanding of Biotechnology and its application to marine natural product drug discovery research.
Author: Jeffrey L. Ram
Publisher: Academic Press
Published: 2018-04-05
Total Pages: 1220
ISBN-13: 0128113545
DOWNLOAD EBOOKConn's Handbook of Models for Human Aging, Second Edition, presents key aspects of biology, nutrition, factors affecting lifespan, methods of age determination, use in research and the disadvantages/advantages of use. Using a multidisciplinary approach, this updated edition is designed as the only comprehensive, current work that covers the diversity in aging models. Chapters on comparative models explore age-related diseases, including Alzheimer's, joint disease, cataracts, cancer and obesity. Also included are new tricks and approaches not available in primary publications. This must-have handbook is an indispensable resource for researchers interested in the mechanisms of aging, gerontologists, health professionals, allied health practitioners and students. - Combines both the methods of study for human aging and animal models - Provides a historical overview and discussion of model availability, key methods and ethical issues - Contains over 200 full color illustrations
Author: Suzanne De La Monte
Publisher: BoD – Books on Demand
Published: 2011-09-06
Total Pages: 380
ISBN-13: 9533079932
DOWNLOAD EBOOKThe Clinical Spectrum of Alzheimer's Disease: The Charge Toward Comprehensive Diagnostic and Therapeutic Strategies is highly informative and current. Acknowledged experts in the field critically review both standard and under-appreciated clinical, behavioral, epidemiological, genetic, and neuroimaging attributes of Alzheimer's disease. The collection covers diverse topics of interest to clinicians and researchers alike. Experienced professionals and newcomers to the field will benefit from the read. The strengths and weaknesses of current clinical, non-invasive, neuro-imaging, and biomarker diagnostic approaches are explained. The perspectives give fresh insights into the process of neurodegeneration. Readers will be enlightened by the evidence that the neural circuits damaged by neurodegeneration are much broader than conventionally taught, suggesting that Alzheimer's could be detected at earlier stages of disease by utilizing multi-pronged diagnostic approaches. This book inspires renewed hope that more effective treatments could be developed based upon the expanding list of potential therapeutic targets.
Author: José Miguel Vela
Publisher: John Wiley & Sons
Published: 2014-07-31
Total Pages: 600
ISBN-13: 3527679367
DOWNLOAD EBOOKThis one-stop reference is the first to present the complete picture -- covering all relevant organisms, from single cells to mammals, as well as all major disease areas, including neurological disorders, cancer and infectious diseases. Addressing the needs of the pharmaceutical industry, this unique handbook adopts a broad perspective on the use of animals in the early part of the drug development process, including regulatory rules and limitations, as well as numerous examples from real-life drug development projects. After a general introduction to the topic, the expert contributors from research-driven pharmaceutical companies discuss the basic considerations of using animal models, including ethical issues. The main part of the book systematically surveys the most important disease areas for current drug development, from cardiovascular to endocrine disorders, and from infectious to neurological diseases. For each area, the availability of animal models for target validation, hit finding and lead profiling is reviewed, backed by numerous examples of both successes and failures among the use of animal models. The whole is rounded off with a discussion of perspectives and challenges. Key knowledge for drug researchers in industry as well as academia.
