Eighty-one million Americans have cardiovascular disease, the arterial damage that leads to the heart attacks and strokes that account for 36 percent of all deaths in the U.S. But few people know that boosting the body's levels of a single molecule of nitric oxide can help prevent, control, and even reverse cardiovascular disease.
Dr. Louis Ignarro discovered "the atom" of cardiovascular health--a tiny molecule called Nitric Oxide. NO, as it is known by chemists, is a signaling molecule produced by the body, and is a vasodilator that helps control blood flow to every part of the body. Dr. Ignarro's findings led to the development of Viagra. Nitric Oxide has a beneficial effect on the cardiovascular system as well. NO relaxes and enlarges the blood vessels, prevents blood clots that trigger strokes and heart attacks, and regulates blood pressure and the accumulation of plaque in the blood vessels. Dr. Ignarro's current research indicates that Nitric Oxide may help lower cholesterol by facilitating the actions of statin drugs like Lipitor. The goal of the regimen presented in NO More Heart Disease is to age proof the cardiovascular system, keeping the vascular network clean and elastic through enhanced NO productivity. The plan is easy-to-follow without extreme lifestyle adjustments, involving taking supplements to stimulate Nitric Oxide production, incorporating NO friendly food into the diet, and a moderate exercise program.
This book describes the role of nitric oxide in health and disease. Nitric oxide is one of the most important molecules produced by humans and is considered the "Holy Grail" in cardiovascular medicine. Loss of nitric oxide production is what leads to chronic disease. Without healthy NO (Nitric Oxide) levels you cannot be healthy and prevent the diseases of aging. Nitric oxide is the secret to anti-aging. This book reveals the latest scientific and medical information so that readers can understand the importance of nitric oxide for optimal health. This eye-opening book teaches how the body makes NO, what goes wrong in people that can't make NO, and perhaps most importantly, how to restore production of this "miracle molecule."
Nitric oxide is a highly potent regulatory molecule with great pharmaceutical potential. This handbook fills a real gap in combining the chemistry of nitric oxide releasing substances with their practical applications in biology and drug design. It covers all classes of nitric oxide donors, from organic nitrates to nitroso compounds, guanidines and metal-NO complexes. In addition to a detailed treatment of the chemistry of NO donors, numerous examples of successful diagnostic and pharmacological applications are discussed, as well as further therapeutic targets for these substances.
The Nobel-Prize-winning discoveries of Dr. Ferid Murad brought nitric oxide into widespread recognition as the "star molecule" of the twentieth century, particularly in the area of human health. The actions of nitric oxide in the body touch almost every important aspect of physical well-being. For the first time, Dr. Murad and Dr. Daniel Chen present a clear description of the physiological functions of nitric oxide in language that everyone can understand. They then show us how to identify early signs of a broad range of nitric-oxide-related illness spanning the gamut from cardiovascular disease through neurological problems to sexual and reproductive issues. They reveal specific steps that we can take to improve and sustain vitality by promoting the action of nitric oxide within our bodies, and they show us how to maximize the amazing effects of nitric oxide so that we can live longer, happier and healthier lives.
Nitrite and Nitrate in Human Health and Disease delivers a comprehensive review of nitrite and nitrate biology, from basic biochemistry to the complex physiology and metabolism of these two naturally occurring molecules in the human body. Well-organized and well referenced chapters cover the rich history of nitrite and nitrate, sources of exposure, and the physiological effects when consumed through foods containing nitrite and nitrate. The chapters are written by leading experts, all of whom share their research and perspectives in order to help define the context for benefits vs. any potential risks associated with nitrite and nitrate use, either through dietary ingestion or therapeutic dosing. This diverse collection of authors includes vascular biologists, physiologists, physicians, epidemiologists, cancer biologists, registered dieticians, chemists, and public health experts from five countries in both academia and government. Nitrite and Nitrate in Human Health and Disease provides a balanced view of nitric oxide biochemistry, and nitrite and nitrate biochemistry in physiology and in the food sciences.
This book will cover the full scope of nanobiosensing, which combines the newest research results in the cross-disciplines of chemistry, biology, and materials science with biosensing and bioanalysis to develop novel detection principles, sensing mechanisms, and device engineering methods. It not only covers the important types of nanomaterials for biosensing applications, including carbon nanotubes, carbon nanofiber, quantum dots, fullerenes, fluorescent and biological molecules, etc., but also illustrates a wide range of sensing principles, including electrochemical detection, fluorescence, chemiluminesence, antibody-antigen interactions, and magnetic detection. The book details novel developments in the methodology and devices of biosensing and bioanalysis combined with nanoscience and nanotechnology, as well as their applications in biomedicine and environmental monitoring. Furthermore, the reported works on the application and biofunction of nanoparticles have attracted extensive attention and interest, thus they are of particular interest to readers. The reader will obtain a rich survey of nanobiosensing technology, including the principles and application of biosensing, the design and biofunctionalization of bionanomaterials, as well as the methodology to develop biosensing devices and bioanalytical systems.
Nitroglycerin and other organic nitrates have been used for over a century in the treatment of angina pectoris. Millions of patients, throughout the world, have placed nitroglycerin tablets under the tongue and have experienced rapid and dramatic relief from the chest pain that frequently occurs as a manifestation of disease of the coronary arteries. The empirical observation of the safe use of nitrates for tile alleviation of the symptoms of angina have led to their widespread medical acceptance. The use of organic nitrates preceded any knowledge of their mechanism of action or their ultimate metabolic fate. Thus, more simply stated, although sub lingual nitrates helped the patients, little was known concerning what these drugs do to the body or what the body does to the drugs. A substantial number of investigators have focused on these questions especially during the last two decades. We now have considerably more insight into the pathways of degradation of organic nitrates and the relationship of the metabolic processes to the biological action of these agents. Similarly, considerable effort has been expended in understanding the mechanism of action of these agents directly on vascular smooth muscle and on cardiac work and performance. Finally, there is a more substantive understanding of the physiology of the coronary circulation as well as the" pathophysiologic manifestations of myocardial disease.
Get out of the health-care trap. Transition into an integrative medicine practice. Return to practicing medicine the way you always dreamt it could be. The United States spends the most health-care dollars per person in the world. Yet we are a sick, fat, and tired nation. Both patients and health-care providers are dissatisfied with our health-care system. We have a diseased management system masquerading as a health-care system. This system is broken! Integrative medicine is a solution to heal our broken system. The Integrative Medicine Solution is a practical guidebook for physician assistants, supervising physicians, nurse practitioners, and other health-care providers who want to transition from treating symptoms to the root causes. Patients are healthier, happier, and less dependent on drugs. Providers are rewarded for spending more time with their patients. It will restore balance and joy in your practice and life. This book is a great introduction and practical guide for PAs or any other health-care providers who are wanting to start their own integrative practice. Jana Pratt, PA-C, Womens Integrative Health Specialist This is an awesome read and a great education piece for all health care providers to read. I think it is a must read. Nathan S. Bryant, PhD, author of The Nitric Oxide (NO) Solution Excellent job . . . your book will shed light on what patients need to know. Mark Starr, MD, author of Hypothyroidism Type 2: The Epidemic