False Positive

False Positive

Author: Theodore Dalrymple

Publisher: Encounter Books

Published: 2019-06-25

Total Pages: 233

ISBN-13: 1641770473

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The New England Journal of Medicine is one of the most important general medical journals in the world. Doctors rely on the conclusions it publishes, and most do not have the time to look beyond abstracts to examine methodology or question assumptions. Many of its pronouncements are conveyed by the media to a mass audience, which is likely to take them as authoritative. But is this trust entirely warranted? Theodore Dalrymple, a doctor retired from practice, turned a critical eye upon a full year of the Journal, alert to dubious premises and to what is left unsaid. In False Positive, he demonstrates that many of the papers it publishes reach conclusions that are not only flawed, but obviously flawed. He exposes errors of reasoning and conspicuous omissions apparently undetected by the editors. In some cases, there is reason to suspect actual corruption. When the Journal takes on social questions, its perspective is solidly politically correct. Practically no debate on social issues appears in the printed version, and highly debatable points of view go unchallenged. The Journal reads as if there were only one possible point of view, though the American medical profession (to say nothing of the extensive foreign readership) cannot possibly be in total agreement with the stances taken in its pages. It is thus more megaphone than sounding board. There is indeed much in the New England Journal of Medicine that deserves praise and admiration. But this book should encourage the general reader to take a constructively critical view of medical news and to be wary of the latest medical doctrines.


Toward Precision Medicine

Toward Precision Medicine

Author: National Research Council

Publisher: National Academies Press

Published: 2012-01-16

Total Pages: 142

ISBN-13: 0309222222

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Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.


AIDS in the Twenty-First Century

AIDS in the Twenty-First Century

Author: T. Barnett

Publisher: Springer

Published: 2002-06-06

Total Pages: 425

ISBN-13: 0230599206

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Essential reading for social and medical scientists and all those interested in infectious diseases and public health, AIDS and the Twenty-First Century examines the social and economic origins and impacts of the HIV/AIDS epidemic. HIV/AIDS is not only a medical problem. It is an indication of the scale of the global crisis in public health. Accessibly written, this book is necessary reading for policymakers, students and all those who are concerned about the relationship between poverty, inequality and infectious diseases.


NEJM Clinical Problem Solving

NEJM Clinical Problem Solving

Author: Sanjay Saint

Publisher: McGraw-Hill Professional

Published: 2006-05-09

Total Pages: 308

ISBN-13:

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Expert clinical problem-solving methods and guidance—from the editors and contributors of the New England Journal of Medicine This invaluable resource from the New England Journal of Medicine expertly addresses methods and challenges in clinical diagnosis. Including the peer-reviewed content of the NEJM’s renowned “Clinical Problem Solving” feature, this powerful resource is packed with case discussions from both ambulatory and hospital practice. Each Case Presentation reveals thought-provoking clinical and laboratory clues as the diagnostic considerations begin to emerge. Subsequent clinical detail and discussion and expert analysis add to the diagnostic picture until a final clinical diagnosis is reached. New England Journal of Medicine: Clinical Problem-Solving features: Published cases drawn from the New England Journal of Medicine reflecting actual patient-management situations that physicians experience in their everyday clinical practice Two brand new, never-before-published chapters on medical decision-making skills and methods Wide-ranging coverage of the major considerations in each case, from underlying pathophysiology to signs from the physical examination to lab testing strategies More than 100 full-color illustrations, tables, and algorithms Meticulously selected references that open up avenues for further study And much more! From cover to cover, New England Journal of Medicine: Clinical Problem-Solving presents the best case analysis, diagnostic thought processes, and problem-solving-- direct from master clinicians.


A Second Opinion

A Second Opinion

Author: Arnold Relman

Publisher: PublicAffairs

Published: 2007-08-05

Total Pages: 244

ISBN-13: 1586485822

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Dr. Arnold Relman, Professor Emeritus at Harvard Medical School and former editor-in-chief of The New England Journal of Medicine brings together sixty years of experience in medicine in a book that holds the keys to a new structure for healthcare based on voluntary private contracts between individuals and not-for-profit, multi-specialty groups of physicians. Timely, provocative, and newly updated, A Second Opinion is a clarion call to action. If we heed Dr. Relman's plan, Americans could at last achieve a lasting, sensible solution to national healthcare.


Clinical Management of Poisoning and Drug Overdose

Clinical Management of Poisoning and Drug Overdose

Author: Lester M. Haddad

Publisher:

Published: 1998

Total Pages: 0

ISBN-13: 9780721664095

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Here's a comprehensive and clinically-specific reference on toxicology. The 3rd Edition includes chapters on overdose during rapid-sequence intubation and conscious sedation, management of complications of thrombolytic agents, and the application of hyperbaric medicine in toxicology. Provides the perfect balance of basic pharmacokinetics and clinical management. Contributions are by experts in the field. Contains completely rewritten and reorganized coverage to encompass the background, pharmacology, pathophysiology, diagnosis, and management of each toxin for clinical treatment throughout a patient's hospital stay. Features a new editor--Michael Shannon, MD--whose experience in pediatric emergency medicine expands the text's coverage of pediatrics...and almost 60 new contributing experts who have made original contributions to their field, with a majority certified by the first approved subspecialty board in toxicology. Presents 10 new chapters that cover: pediatric resuscitation, antibiotic hypersensitivity and anaphylaxis, MAO inhibitors and the serotonin syndrome, herbal and alternative medicine, and thrombolytic therapy, and more. OUTSTANDING FEATURES: Uses a clinical approachfor maximum clinical relevance, addressing how toxins affect humans, not animals. Incorporates the experience of many expert authors from numerous specialties for a Comprehensive review of toxicology and an authoritative overview of each specialty. Contains colour plates of toxic natural life, including various snakes, mushrooms, plants, and marine life--a feature unique to this book.


Developing Clinical Problem-solving Skills

Developing Clinical Problem-solving Skills

Author: Howard S. Barrows

Publisher: W W Norton & Company Incorporated

Published: 1991

Total Pages: 226

ISBN-13: 9780393710106

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“I think this is an outstanding book and one that I would recommend for our students. If students digest the lessons of this book the level of practice of medicine in this country will rise significantly!' —Roy H. Maffly, M.D., Associate Dean for Student Affairs, Stanford University School of Medicine