The Lock and Key of Medicine

The Lock and Key of Medicine

Author: Lara Marks

Publisher: Yale University Press

Published: 2015-01-01

Total Pages: 345

ISBN-13: 0300167733

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This book is the first to tell the extraordinary yet unheralded history of monoclonal antibodies, or Mabs. Though unfamiliar to most nonscientists, these microscopic protein molecules are everywhere, quietly shaping our lives and healthcare. They have radically changed understandings of the pathways of disease, enabling faster, cheaper, and more accurate clinical diagnostic testing. And they lie at the heart of the development of genetically engineered drugs such as interferon and blockbuster personalized therapies such as Herceptin. Lara V. Marks recounts the risks and opposition that a daring handful of individuals faced while discovering and developing Mabs, and she addresses the related scientific, medical, technological, business, and social challenges that arose. She offers a saga of entrepreneurs who ultimately changed the healthcare landscape and brought untold relief to millions of patients. Even so, controversies over Mabs remain, which the author explores through the current debates on their cost-effectiveness.


An Anthropology of Biomedicine

An Anthropology of Biomedicine

Author: Margaret M. Lock

Publisher: John Wiley & Sons

Published: 2011-09-09

Total Pages: 521

ISBN-13: 1444357905

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An Anthropology of Biomedicine is an exciting new introduction to biomedicine and its global implications. Focusing on the ways in which the application of biomedical technologies bring about radical changes to societies at large, cultural anthropologist Margaret Lock and her co-author physician and medical anthropologist Vinh-Kim Nguyen develop and integrate the thesis that the human body in health and illness is the elusive product of nature and culture that refuses to be pinned down. Introduces biomedicine from an anthropological perspective, exploring the entanglement of material bodies with history, environment, culture, and politics Develops and integrates an original theory: that the human body in health and illness is not an ontological given but a moveable, malleable entity Makes extensive use of historical and contemporary ethnographic materials around the globe to illustrate the importance of this methodological approach Integrates key new research data with more classical material, covering the management of epidemics, famines, fertility and birth, by military doctors from colonial times on Uses numerous case studies to illustrate concepts such as the global commodification of human bodies and body parts, modern forms of population, and the extension of biomedical technologies into domestic and intimate domains Winner of the 2010 Prose Award for Archaeology and Anthropology


The Oxford Medical Companion

The Oxford Medical Companion

Author: John Nicholas Walton

Publisher: Oxford University Press, USA

Published: 1994

Total Pages: 1078

ISBN-13:

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This rich, intelligent guide to the state of medical science is a thoroughly revised and edited version of Walton's massive Oxford Companion to Medicine. Accessible, convenient and up to date, it is an invaluable reference for doctors, students, and medical professionals of all kinds. 70 halftones and line drawings.


Antibodies and Their Role in Therapeutics

Antibodies and Their Role in Therapeutics

Author: Roohi Bansal

Publisher: Roohi Bansal

Published: 2021-12-04

Total Pages: 390

ISBN-13: 9789355781604

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Beginning with the structure, types, functions, and gene organization of antibodies, the book aims to shine a detailed light on the monoclonal antibodies (often referred to as mAbs) that have revolutionized the fields of therapeutics and diagnostics. The book describes the different ways of generating chimeric, humanized, and fully human monoclonal antibodies, emphasizing phage display, hybridoma, and rDNA technology. In addition, the book focuses on the various recombinant antibody formats in detail: Drug conjugates: Antibody-drug conjugates (ADCs), Immunotoxins (Recombinant, Humanized and Fully Human) and Antibody-antibiotic conjugate (AAC) Bispecific antibodies: scFv based (BiTE, DARTs and TandAbs) and Full-length IgG based Abzymes and Antibody-directed enzyme prodrug therapy (ADEPT) Fc-fusion proteins Single-domain antibodies (VHH and IgNAR sdAb) The book discusses the various therapeutic applications of monoclonal antibodies, along with the immunogenicity issues. The book also covers the modes of administration and side effects of monoclonal antibodies, along with the challenges and issues faced while developing a monoclonal antibody into a therapeutic agent. Modifications introduced by the researchers to decrease the immunogenicity issues and increase the efficacy of therapeutic mAbs are also described. The book is an invaluable resource for researchers and students in biology and medicine, biotechnology, immunology, genetics, molecular biology, and anyone interested in antibody engineering.


Take the Key and Lock Her Up (Embassy Row, Book 3)

Take the Key and Lock Her Up (Embassy Row, Book 3)

Author: Ally Carter

Publisher: Scholastic Inc.

Published: 2016-12-27

Total Pages: 286

ISBN-13: 054565498X

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New York Times bestselling author Ally Carter returns with the third entry in this runaway series. For the past three years, Grace Blakely has been desperate to find out the truth about her mother's murder. She thought it would bring her peace. She thought it would lead her to answers. She thought she could put the past to rest. But the truth has only made her a target. And the past? The only way to put the past to rest is for Grace to kill it once and for all.


Ghost Medicine

Ghost Medicine

Author: Aimée Thurlo

Publisher: Macmillan

Published: 2013-11-12

Total Pages: 321

ISBN-13: 0765334038

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When a former police officer is murdered, Navajo Special Investigator Ella Clah will do anything to bring his killer to justice


A Dictionary of Biology

A Dictionary of Biology

Author: Elizabeth Martin

Publisher: Oxford University Press, USA

Published: 2015

Total Pages: 673

ISBN-13: 0198714378

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Fully revised and updated for the seventh edition, this market-leading dictionary is the perfect guide for anyone studying biology, either at school or university. With more than 5,500 clear and concise entries, it provides comprehensive coverage of biology, biophysics, and biochemistry. Over 250 new entries include terms such as Broca's area, comparative genomic hybridization, mirror neuron, and Pandoravirus. Appendices include classifications of the animal and plant kingdoms, the geological time scale, major mass extinctions of species, model organisms and their genomes, Nobel prizewinners, and a new appendix on evolution. Entry-level web links to online resources can be accessed via a companion website.


The Lock-and-Key Principle

The Lock-and-Key Principle

Author: Jean-Paul Behr

Publisher: John Wiley & Sons

Published: 2008-04-30

Total Pages: 336

ISBN-13: 0470511400

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Published 100 years after Emil Fischer first proposed the lock-and-key principle, this volume provides a complete review of the subject to date and offers suggestions for futher research. The major impact of the lock-and-key principle on the chemical, biomedical and materials sciences is discussed by leaders in the field, with chapters dedicated to molecular recognition, nucleic acid and protein chemistry, crystallography and the development of Emil Fischer's initial ideas. The Lock-and-Key Principle is the most up-to-date review of progress in supramolecular chemistry and the lock-and-key principle and will become the essential guide to the past, present and future of this remarkable principle.


Psychology for Medicine

Psychology for Medicine

Author: Susan Ayers

Publisher: SAGE

Published: 2011-07-08

Total Pages: 550

ISBN-13: 1446259501

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"As the fundamental importance of psychological aspects of medical practice becomes ever more evident, and a correspondingly greater knowledge of psychology is required of medical graduates, books like this one must become essential reading for all medical students." - Michael Sharpe MD, FRCP FRCPsych, Professor of Psychological Medicine, University of Edinburgh "It′s a great textbook, the application to Medicine is nicely outlined and the case studies illustrating the points further are brilliant. It′s easy to read and follow and really highlights the importance of Psychology in Medicine. I will definitely be recommending this text to my students!" - Dr Harbinder Sandhu, Health Psychology Institute of Clinical Education, University of Warwick This first-of-its-kind, comprehensive textbook covers all the psychology an undergraduate medical student needs to know. The authors show the importance of applied psychological theory and evidence to medicine, and offer enough depth on the subject to span an entire degree. Split into four sections, the book is a unique mix of psychological theory and evidence with implications for clinical practice, clinical tips and case studies. Psychology and Health: covers core topics such as stress, symptom perception, health behaviour and chronic illness. Basic Foundations of Psychology: explores areas of biological, developmental, cognitive and social psychology relevant to medicine. Body Systems: psychological research specific to body systems, including cardiovascular, respiratory, gastro-intestinal, immunology and reproduction. Health-Care Practice covers clinical skills and practice, including chapters on evidence-based medicine, communication skills and psychological intervention. With a full colour text design, each chapter follows the same accessible format which includes summaries, learning objectives, case studies, research examples, applications to clinical practice, further reading and short answer questions. They include the latest psychological theory and research evidence.


The Alzheimer Conundrum

The Alzheimer Conundrum

Author: Margaret Lock

Publisher: Princeton University Press

Published: 2015-10-20

Total Pages: 328

ISBN-13: 0691168474

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Why our approaches to Alzheimer's and dementia are problematic and contradictory Due to rapidly aging populations, the number of people worldwide experiencing dementia is increasing, and the projections are grim. Despite billions of dollars invested in medical research, no effective treatment has been discovered for Alzheimer's disease, the most common form of dementia. The Alzheimer Conundrum exposes the predicaments embedded in current efforts to slow down or halt Alzheimer’s disease through early detection of pre-symptomatic biological changes in healthy individuals. Based on a meticulous account of the history of Alzheimer’s disease and extensive in-depth interviews, Margaret Lock highlights the limitations and the dissent associated with biomarker detection. Lock argues that basic research must continue, but should be complemented by a public health approach to prevention that is economically feasible, more humane, and much more effective globally than one exclusively focused on an increasingly harried search for a cure.