Bone Aging and Osteoporosis: Recent Evidence Focusing on Plant-Based Natural Products
Bone Aging and Osteoporosis: Recent Evidence Focusing on Plant-Based Natural Products

Author: Lingfeng Zeng

Publisher: Frontiers Media SA

Published: 2024-03-08

Total Pages: 170

ISBN-13: 2832545955

DOWNLOAD EBOOK

The human skeleton undergoes a life-long remodeling process. Bone homeostasis requires a potential balance between bone-resorbing osteoclasts and bone-forming osteoblasts. With old age, bone homeostasis undergoes deregulation, and normal bone remodeling could not make bone mass stable, thus causing osteopenia and osteoporosis. Osteoporosis is a systemic bone disease characterized by reduced bone mass, degraded bone microstructure, increased bone fragility and raised risk of fracture. Osteoporosis is a frequently occurring and common disease in the aging population, especially in postmenopausal women and elderly men. The updated research found that one-third of women aged 60 to 70 suffer from osteoporosis; Two-thirds of women aged 80 years or older have osteoporosis. About 20-25% of women over 50 years of age have one or more vertebral fractures. Recent research evidence indicates that an increasing number of plant-based natural products (or secondary metabolites), such as polyunsaturated fatty acids, phytosterols, flavonoids, and other botanicals active compounds, have beneficial effects on the risk of osteoporosis. Compared with conventional therapies, plant-based natural products with thousands of years of medical use experience are gradually approved for clinical use due to fewer adverse reactions, low toxicity, high efficiency and good tolerance. Natural products have been an important source of inspiration for new drug development. However, most of the evidence regarding the anti-osteoporosis effects of natural products comes from in vitro and preclinical in vivo studies, and only a few natural products have been used clinically. All of these above-mentioned still require rigorously designed studies and further verification.

Nutrigenomics and Proteomics in Health and Disease
Nutrigenomics and Proteomics in Health and Disease

Author: Martin Kussmann

Publisher: John Wiley & Sons

Published: 2017-05-08

Total Pages: 350

ISBN-13: 1119098831

DOWNLOAD EBOOK

Now in a revised second edition, Nutrigenomics and Proteomics in Health and Disease brings together the very latest science based upon nutrigenomics and proteomics in food and health. Coverage includes many important nutraceuticals and their impact on gene interaction and health. Authored by an international team of multidisciplinary researchers, this book acquaints food and nutrition professionals with these new fields of nutrition research and conveys the state of the science to date. Thoroughly updated to reflect the most current developments in the field, the second edition includes six new chapters covering gut health and the personal microbiome; gut microbe-derived bioactive metabolites; proteomics and peptidomics in nutrition; gene selection for nutrigenomic studies; gene-nutrient network analysis, and nutrigenomics to nutritional systems biology. An additional five chapters have also been significantly remodelled. The new text includes a rethinking of in vitro and in vivo models with regard to their translatability into human phenotypes, and normative science methods and approaches have been complemented by more comprehensive systems biology-based investigations, deploying a multitude of omic platforms in an integrated fashion. Innovative tools and methods for statistical treatment and biological network analysis are also now included.

The Yellow Emperor's Classic of Medicine
The Yellow Emperor's Classic of Medicine

Author: Maoshing Ni

Publisher: Shambhala Publications

Published: 1995-05-10

Total Pages: 339

ISBN-13: 0834825767

DOWNLOAD EBOOK

The Neijing is one of the most important classics of Taoism, as well as the highest authority on traditional Chinese medicine. Its authorship is attributed to the great Huang Di, the Yellow Emperor, who reigned during the third millennium BCE. This new translation consists of the eighty-one chapters of the section of the Neijing known as the Suwen, or "Questions of Organic and Fundamental Nature." (The other section, called the Lingshu, is a technical book on acupuncture and is not included here.) Written in the form of a discourse between Huang Di and his ministers, The Yellow Emperor's Classic of Medicine contains a wealth of knowledge, including etiology, physiology, diagnosis, therapy, and prevention of disease, as well as in-depth investigation of such diverse subjects as ethics, psychology, and cosmology. All of these subjects are discussed in a holistic context that says life is not fragmented, as in the model provided by modern science, but rather that all the pieces make up an interconnected whole. By revealing the natural laws of this holistic universe, the book offers much practical advice on how to promote a long, happy, and healthy life. The original text of the Neijing presents broad concepts and is often brief with details. The translator's elucidations and interpretations, incorporated into the translation, help not only to clarify the meaning of the text but also to make it a highly readable narrative for students—as well as for everyone curious about the underlying principles of Chinese medicine.

Microbiome in Human Health and Disease
Microbiome in Human Health and Disease

Author: Pallaval Veera Bramhachari

Publisher: Springer Nature

Published: 2021-10-18

Total Pages: 306

ISBN-13: 9811631565

DOWNLOAD EBOOK

The book provides an overview on how the microbiome contributes to human health and disease. The microbiome has also become a burgeoning field of research in medicine, agriculture & environment. The readers will obtain profound knowledge on the connection between intestinal microbiota and immune defense systems, medicine, agriculture & environment. The book may address several researchers, clinicians and scholars working in biomedicine, microbiology and immunology. The application of new technologies has no doubt revolutionized the research initiatives providing new insights into the dynamics of these complex microbial communities and their role in medicine, agriculture & environment shall be more emphasized. Drawing on broad range concepts of disciplines and model systems, this book primarily provides a conceptual framework for understanding these human-microbe, animal-microbe & plant-microbe, interactions while shedding critical light on the scientific challenges that lie ahead. Furthermore this book explains why microbiome research demands a creative and interdisciplinary thinking—the capacity to combine microbiology with human, animal and plant physiology, ecological theory with immunology, and evolutionary perspectives with metabolic science.This book provides an accessible and authoritative guide to the fundamental principles of microbiome science, an exciting and fast-emerging new discipline that is reshaping many aspects of the life sciences. These microbial partners can also drive ecologically important traits, from thermal tolerance to diet in a typical immune system, and have contributed to animal and plant diversification over long evolutionary timescales. Also this book explains why microbiome research presents a more complete picture of the biology of humans and other animals, and how it can deliver novel therapies for human health and new strategies.