The Histone Code and Beyond
The Histone Code and Beyond

Author: Shelley L. Berger

Publisher: Springer Science & Business Media

Published: 2007-01-19

Total Pages: 223

ISBN-13: 354037633X

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Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book.

The Histone Code and Beyond
The Histone Code and Beyond

Author: Shelley L. Berger

Publisher: Springer

Published: 2009-09-02

Total Pages: 215

ISBN-13: 9783540813231

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Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book.

Beyond Mechanism
Beyond Mechanism

Author: Brian G. Henning

Publisher: Rowman & Littlefield

Published: 2013

Total Pages: 488

ISBN-13: 0739174363

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It has been said that new discoveries and developments in the human, social, and natural sciences hang "in the air" (Bowler, 1983; 2008) prior to their consummation. While neo-Darwinist biology has been powerfully served by its mechanistic metaphysic and a reductionist methodology in which living organisms are considered machines, many of the chapters in this volume place this paradigm into question. Pairing scientists and philosophers together, this volume explores what might be termed "the New Frontiers" of biology, namely contemporary areas of research that appear to call an updating, a supplementation, or a relaxation of some of the main tenets of the Modern Synthesis. Such areas of investigation include: Emergence Theory, Systems Biology, Biosemiotics, Homeostasis, Symbiogenesis, Niche Construction, the Theory of Organic Selection (also known as "the Baldwin Effect"), Self-Organization and Teleodynamics, as well as Epigenetics. Most of the chapters in this book offer critical reflections on the neo-Darwinist outlook and work to promote a novel synthesis that is open to a greater degree of inclusivity as well as to a more holistic orientation in the biological sciences.

Beyond Sex Differences
Beyond Sex Differences

Author: Barry Keverne

Publisher: Cambridge University Press

Published: 2017-09-07

Total Pages: 233

ISBN-13: 1108416853

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This book examines the evolutionary lead taken by the matriline in providing the intergenerational co-adaptations required for successful pregnancy.

Metaphors and Analogies in Sciences and Humanities
Metaphors and Analogies in Sciences and Humanities

Author: Shyam Wuppuluri

Publisher: Springer Nature

Published: 2022-05-30

Total Pages: 590

ISBN-13: 3030906884

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In this highly-interdisciplinary volume, we systematically study the role of metaphors and analogies in (mis)shaping our understanding of the world. Metaphors and Analogies occupy a prominent place in scientific discourses, as they do in literature, humanities and at the very level of our thinking itself. But when misused they can lead us astray, blinding our understanding inexorably. How can metaphors aid us in our understanding of the world? What role do they play in our scientific discourses and in humanities? How do they help us understand and skillfully deal with our complex socio-political scenarios? Where is the dividing line between their use and abuse? Join us as we explore some of these questions in this volume.

Cognition Beyond the Brain
Cognition Beyond the Brain

Author: Stephen J. Cowley

Publisher: Springer

Published: 2017-03-28

Total Pages: 344

ISBN-13: 3319491156

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This book challenges neurocentrism by advocating a systemic view of cognition based on investigating how action shapes the experience of thinking, placing interactivity at its heart. This systemic viewpoint makes three main claims. First, that many elaborate cognitive skills like language, problem solving and human-computer interaction (HCI) are based in sense-saturated coordination or interactivity. Second, interactivity produces a tightly woven scaffold of resources, some internal to the agent and others external, that elevates and transforms thinking. Third, human agents entwine brains, bodies and their surroundings as they manage multi-scalar dynamics. This new edition continues to demonstrate how a systemic perspective casts a productive light on thinking in applied domains such as crime scene analysis, the use of information technology in construction, and computer-meditated trusts and presents new studies on the cognitive ecology of the web, multi-scalar temporal and organisational cognition and the importance of interactive material engagement in digital architecture. Authors use various scales of the systemic viewpoint to illustrate how bodies and artefacts shape thinking, but in all cases the experience of materiality is meshed with activity that involves the world beyond the body. Cognition Beyond the Brain is a valuable reference for researchers, practitioners and graduate students within the fields of Computer Science, Psychology, Linguistics and Cognitive Sciences.